Health
Study Links Eating Habits to Effectiveness of Popular Weight Loss Drugs
Doctors may need to consider their patients’ eating behaviours before prescribing blockbuster weight loss drugs, new research suggests.
A Japanese study has found that people who eat in response to emotions may not see the same benefits from widely used medications such as Ozempic, Wegovy, and Mounjaro as those who overeat when food looks or smells appealing. These drugs, known as glucagon-like peptide-1 (GLP-1) receptor agonists, mimic a hormone that reduces appetite and are increasingly prescribed for both diabetes and weight loss.
The year-long study, published in Frontiers in Clinical Diabetes and Healthcare, tracked 92 patients with diabetes who were taking GLP-1 drugs. Researchers from Gifu University and Kyoto University collected data on participants’ diets, blood markers, body composition, and weight changes. They also assessed patients’ relationships with food, focusing on three main eating patterns: eating in response to negative emotions, eating when food appeared appetising, and restricting diet for weight loss purposes.
Diverging Results Based on Eating Style
Most participants lost significant weight and showed improvements in cholesterol levels during the first year of treatment. However, outcomes varied depending on eating habits.
Those who tended to overeat because food looked appealing experienced the most consistent weight loss and improved blood sugar control over 12 months. In contrast, participants who relied on food to manage emotions were less likely to sustain benefits.
At the three-month mark, many patients showed greater control over their eating and were less likely to eat for emotional reasons or because of the appearance of food. But by the 12-month point, emotional and restrictive eating habits had re-emerged, suggesting that psychological factors may undermine long-term progress.
“Individuals with prominent emotional eating tendencies may require additional behavioural or psychological support,” said Dr Takehiro Kato, clinical lecturer at Gifu University and one of the study’s authors. “One possible explanation is that emotional eating is more strongly influenced by psychological factors which may not be directly addressed by GLP-1 receptor agonist therapy.”
Calls for More Research
While the findings highlight a potential link between eating behaviour and treatment outcomes, the researchers stressed that larger studies are needed before changes to clinical practice can be made.
“While our study suggests a potential association between external eating behaviour and treatment response to GLP-1 receptor agonists, these findings remain preliminary,” said Dr Daisuke Yabe, professor at Kyoto University and co-author of the study. “Further evidence is necessary before they can be implemented in clinical practice.”
The results underline the growing recognition that medication alone may not be sufficient for lasting weight loss, especially for patients who struggle with emotional eating. Experts say combining drug treatment with dietary guidance and psychological support may be the most effective path forward.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
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Health
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