Health
Study Links High-Potency Cannabis to Greater Risk of Psychosis and Addiction
A sweeping new analysis has found that cannabis products with high levels of the psychoactive compound THC may significantly raise the risk of psychosis, schizophrenia, and addiction, heightening concerns among researchers and health officials as cannabis use rises worldwide.
The study, published in the Annals of Internal Medicine, reviewed 99 research papers conducted between 1977 and 2023, covering more than 220,000 people. It concluded that products containing higher concentrations of delta-9-tetrahydrocannabinol (THC) — the chemical responsible for the “high” associated with cannabis — are strongly linked to serious mental health risks.
In Europe, cannabis remains largely illegal, but the European Union Drugs Agency (EUDA) estimates that 4.3 million people use the drug daily or nearly every day. Consumption spans smoking herbal marijuana, eating edibles such as gummies, and vaping potent concentrates like hash oil, “shatter,” and “dabs.”
The potency of these products has increased sharply in recent years. In 2023, cannabis resin in Europe had an average THC concentration of 23%, compared with 11% for herbal cannabis, according to the EUDA. By comparison, researchers considered products with THC levels above 10% or 5 milligrams per serving to be “high-potency.”
The review found that people using such products faced an elevated risk of psychosis and schizophrenia within hours of consumption. Long-term use was also tied to cannabis use disorder — a form of addiction — as well as respiratory problems and dependency symptoms.
“There’s a real warning in these findings,” said Dr. Jonathan Samet, a co-author of the study and professor of epidemiology at the Colorado School of Public Health. “We really need to be carefully watching what the consequences of these products are.”
Findings for more common mental health conditions, such as anxiety and depression, were mixed. Some evidence suggested high-potency THC could ease symptoms in patients with cancer or neurological disorders, but other studies identified harmful effects. Overall, researchers cautioned that the benefits were limited and often tied to specific medical conditions.
The EUDA has long warned that frequent and heavy cannabis use can exacerbate psychiatric problems, increase dependence, and worsen lung health. The new findings, while not yet definitive, reinforce these concerns and could influence future regulations.
Samet noted that any attempt to regulate THC levels would face challenges, since consumers could simply adjust their dosage. “There’s not a simple solution when it comes to potency,” he said. Still, he argued that greater awareness is essential, especially for those with existing mental health vulnerabilities.
“People who say, ‘Well, I’m using THC, what about it?’ … need to know that there are risks,” Samet added.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
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Health
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