Health
No Proven Link Between Paracetamol Use in Pregnancy and Autism or ADHD, Major Review Finds
A new comprehensive review has found no reliable evidence that taking paracetamol during pregnancy increases the risk of autism or attention-deficit/hyperactivity disorder (ADHD) in children. The findings, published in The BMJ on Monday, counter recent claims that have reignited global debate over the safety of the widely used painkiller.
The review, conducted by researchers from leading universities and institutions in the United Kingdom, Australia, and Spain, analysed existing scientific studies after renewed public concern following remarks by former US President Donald Trump in September. During a campaign event, Trump urged pregnant women to “fight like hell” to avoid paracetamol, claiming it was linked to autism — a statement that drew swift backlash from medical experts.
The researchers reviewed nine previous systematic studies that examined a possible connection between paracetamol use in pregnancy and later diagnoses of autism or ADHD in children. While all nine suggested an association, the team found that most of them were based on weak or flawed evidence.
According to the review, many of the earlier studies failed to adjust for key health and lifestyle factors such as genetics, parental mental health, or environmental influences — variables that could affect a child’s development. Seven of the nine reviews also warned readers to interpret their findings cautiously due to the risk of bias and confounding factors.
“Our aim was to review all the existing research to understand the quality of the evidence and help healthcare professionals communicate accurate information to expectant mothers,” said Professor Shakila Thangaratinam, a women’s health expert at the University of Liverpool and one of the study’s authors. She told Euronews Health that the overall confidence in existing evidence was rated “low to critically low,” meaning it cannot be used to establish a causal link between paracetamol and neurodevelopmental disorders.
The review noted that when genetic and environmental influences were taken into account, any association between paracetamol use and the risk of autism or ADHD either disappeared or dropped sharply.
Paracetamol, known as acetaminophen in the United States and sold under brand names such as Tylenol, is one of the few pain and fever medications considered safe for use during pregnancy. Despite this, Trump’s comments led the US Food and Drug Administration (FDA) to recommend that manufacturers include warnings about potential neurological risks on paracetamol packaging.
The authors of the BMJ review urged more high-quality studies that examine how dosage, timing, and duration of paracetamol exposure during pregnancy might influence foetal development. They also warned against drawing conclusions or changing medical guidance based on unverified claims.
Professor Thangaratinam emphasised that decisions about medication during pregnancy should be grounded in strong evidence. “There is a sex and gender gap in science, and studies like this highlight the need for prioritising and investing in research focused on women’s health — particularly during pregnancy,” she said.
The review reinforces existing advice from global health agencies that paracetamol remains a safe and effective option for managing pain and fever in pregnancy when used as directed.
Health
World Cup Emotion Can Strain the Heart, Cardiologists Warn Fans at Risk
As the World Cup begins, medical experts are cautioning football fans with underlying heart conditions that the emotional intensity of matches can place unexpected strain on the cardiovascular system.
Cardiologists say that the excitement, tension, and anxiety generated during high-stakes games can trigger physical reactions similar to intense exercise, raising heart rate, blood pressure, and stress hormones.
“Intense emotions, whether positive or negative, can act as ‘precipitating risk factors’ for cardiovascular events such as heart attack,” said Paola Santalucia, a cardiologist and board member of the European Heart Network.
She explained that moments of extreme excitement, such as a decisive penalty shootout or a last-minute goal, may pose risks for people already living with heart disease. Those with additional risk factors, including hypertension, obesity, or smoking habits, are also advised to be cautious during emotionally charged matches.
Research using wearable devices has shown that during major football events, some fans experience heart rates climbing as high as 150 beats per minute. That level is comparable to sprinting and reflects how strongly the body reacts to emotional stress.
A study examining supporters during the 2025 German Cup final found that even watching from home can significantly affect physiological responses. “They still had an increase in heart rate that compares to walking, even though they didn’t walk,” said Christian Deutscher, professor of sports economics at Bielefeld University and co-author of the study.
He noted that the most intense reactions often occur not during goals themselves, but during moments of uncertainty such as VAR checks, penalty shootouts, or shots striking the post. These unpredictable situations, he said, are what drive the strongest emotional and physical responses among fans.
Deutscher also pointed out that stadium spectators may experience even greater strain due to environmental factors such as heat and alcohol consumption.
However, experts emphasize that football itself is not inherently dangerous. Instead, it is the body’s natural response to excitement that can create temporary stress.
“The adrenergic stimulation is at its max: extreme high blood pressure, high heart rate, and adrenaline, cortisol, skyrocketing,” said Dan Atar, professor of cardiology at Oslo University Hospital. In rare cases, he added, this surge can contribute to the rupture of arterial plaque in vulnerable individuals, potentially leading to a heart attack.
Atar stressed that such events can occur in everyday situations as well, including physical exertion like shoveling snow. “It is in no way dangerous to watch a football game,” he said. “All this is physiologic. It’s not dangerous to be excited.”
Still, he acknowledged that combining emotional stress with alcohol, heat, and pre-existing conditions can increase risk for some viewers.
Doctors advise those at higher risk to continue prescribed medications, limit alcohol intake, avoid smoking, and watch for warning signs such as chest pain or irregular heartbeat.
“The key message is not to avoid enjoying the match, but to do so with moderation and awareness,” Santalucia said.
Health
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Health
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