Health
No Proven Link Between Paracetamol Use in Pregnancy and Autism or ADHD, Major Review Finds
A new comprehensive review has found no reliable evidence that taking paracetamol during pregnancy increases the risk of autism or attention-deficit/hyperactivity disorder (ADHD) in children. The findings, published in The BMJ on Monday, counter recent claims that have reignited global debate over the safety of the widely used painkiller.
The review, conducted by researchers from leading universities and institutions in the United Kingdom, Australia, and Spain, analysed existing scientific studies after renewed public concern following remarks by former US President Donald Trump in September. During a campaign event, Trump urged pregnant women to “fight like hell” to avoid paracetamol, claiming it was linked to autism — a statement that drew swift backlash from medical experts.
The researchers reviewed nine previous systematic studies that examined a possible connection between paracetamol use in pregnancy and later diagnoses of autism or ADHD in children. While all nine suggested an association, the team found that most of them were based on weak or flawed evidence.
According to the review, many of the earlier studies failed to adjust for key health and lifestyle factors such as genetics, parental mental health, or environmental influences — variables that could affect a child’s development. Seven of the nine reviews also warned readers to interpret their findings cautiously due to the risk of bias and confounding factors.
“Our aim was to review all the existing research to understand the quality of the evidence and help healthcare professionals communicate accurate information to expectant mothers,” said Professor Shakila Thangaratinam, a women’s health expert at the University of Liverpool and one of the study’s authors. She told Euronews Health that the overall confidence in existing evidence was rated “low to critically low,” meaning it cannot be used to establish a causal link between paracetamol and neurodevelopmental disorders.
The review noted that when genetic and environmental influences were taken into account, any association between paracetamol use and the risk of autism or ADHD either disappeared or dropped sharply.
Paracetamol, known as acetaminophen in the United States and sold under brand names such as Tylenol, is one of the few pain and fever medications considered safe for use during pregnancy. Despite this, Trump’s comments led the US Food and Drug Administration (FDA) to recommend that manufacturers include warnings about potential neurological risks on paracetamol packaging.
The authors of the BMJ review urged more high-quality studies that examine how dosage, timing, and duration of paracetamol exposure during pregnancy might influence foetal development. They also warned against drawing conclusions or changing medical guidance based on unverified claims.
Professor Thangaratinam emphasised that decisions about medication during pregnancy should be grounded in strong evidence. “There is a sex and gender gap in science, and studies like this highlight the need for prioritising and investing in research focused on women’s health — particularly during pregnancy,” she said.
The review reinforces existing advice from global health agencies that paracetamol remains a safe and effective option for managing pain and fever in pregnancy when used as directed.
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Irregular Sleep Patterns Linked to Higher Anxiety Risk Among Teenagers
Teenagers who regularly change their sleeping patterns between weekdays and weekends may face a greater risk of anxiety, according to a new study from researchers at the University of Southampton in the United Kingdom.
The findings come as students return to school after the summer break, when many adolescents may have become accustomed to later nights and longer mornings. The shift back to early school schedules can create a mismatch between weekday and weekend sleep patterns, a phenomenon researchers describe as “social jet lag.”
A review of 12 studies involving more than 230,000 participants found that teenagers experiencing greater levels of social jet lag were more likely to report higher levels of anxiety. The relationship also appeared to work in the opposite direction, with higher anxiety associated with greater disruption to sleep schedules.
However, researchers stressed that the findings show an association rather than proving that irregular sleep directly causes anxiety.
The study highlights the importance of encouraging healthy and consistent sleeping habits as part of efforts to support adolescent mental health. Anxiety is already one of the most common mental health problems among young people.
The World Health Organization estimates that anxiety disorders affect about 4.4% of children aged 10 to 14 and 5.5% of those aged 15 to 19 worldwide. Such disorders involve persistent fear or nervousness that can be difficult to control.
Researchers say adolescence is a particularly important period for sleep because biological changes naturally alter young people’s body clocks.
Sarah Chellappa, a co-author of the study from the University of Southampton, said teenagers generally experience a shift toward later sleep during puberty.
“During puberty, the body’s internal clock usually shifts back by a few hours,” she said, meaning teenagers naturally become sleepy later and may need to wake later as well.
Early school starts can conflict with this biological change. Social activities, online communication and other demands can also reduce the amount of sleep teenagers get during the week.
Hannah Ravenhall, lead author of the study, said the issue should not be viewed solely as a matter of individual responsibility.
She said broader social systems can influence young people’s sleep and called for greater recognition of the biological changes that occur during adolescence.
The researchers suggested that schools could consider whether their start times adequately reflect teenagers’ changing sleep needs. Parents could also review evening routines, including rules around screen use.
Rather than simply encouraging teenagers to go to bed earlier, the researchers argue that more consistent schedules and changes to the environments in which young people live and study could help support better sleep and mental wellbeing.
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