Health
New AI Tool Could Accelerate Heart Disease Treatments, Study Finds
Scientists at Imperial College London have developed an artificial intelligence tool that could speed up the discovery of treatments for heart disease and eventually support more personalised care. The technology, known as CardioKG, combines detailed heart scans with large medical databases to identify genes linked to cardiovascular conditions and predict which drugs may be most effective.
Cardiovascular diseases remain the leading cause of death and disability in the European Union, causing around 1.7 million deaths each year and affecting an estimated 62 million people, according to the Organisation for Economic Co-operation and Development (OECD). Researchers hope the AI tool can help address this significant health burden by accelerating drug discovery and improving treatment outcomes.
CardioKG was built using heart imaging data from thousands of participants in the UK Biobank, including patients with atrial fibrillation, heart failure, and heart attacks, as well as healthy volunteers. By integrating genetic information, disease data, and drug profiles into a single knowledge graph, the researchers say the system can make more precise predictions about which medications could benefit patients with specific heart conditions.
“One of the advantages of knowledge graphs is that they integrate information about genes, drugs, and diseases,” said Declan O’Regan, group leader of the Computational Cardiac Imaging Group at Imperial College London. He added that including heart imaging in the model significantly improved the identification of new genes and potential drug therapies.
The study highlighted several drugs for potential repurposing. Methotrexate, commonly used to treat rheumatoid arthritis, was suggested as a possible therapy for heart failure, while gliptins, a class of diabetes medications, could benefit patients with atrial fibrillation. The analysis also indicated a potential protective effect of caffeine for some atrial fibrillation patients, although researchers stressed this does not justify changing caffeine consumption without medical advice.
The team aims to expand CardioKG into a dynamic, patient-focused framework that can capture disease progression over time. Khaled Rjoob, the study’s first author, said the approach could enable more personalised treatment strategies and help predict when diseases are likely to develop. “This will open new possibilities for personalised treatment and predicting disease trajectories,” he said.
Researchers also believe the underlying technology could be applied beyond heart disease, including for conditions such as brain disorders and obesity, offering a broader tool for accelerating medical research and drug development.
By combining AI, medical imaging, and genetic data, CardioKG represents a promising step toward more targeted therapies and improved outcomes for patients with cardiovascular disease, potentially transforming how clinicians understand and treat heart conditions in the future.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
Europe Records Sharp Rise in Sexually Transmitted Infections, ECDC Warns
Health
White House Rejects Report It Blocked Return of Ebola-Infected US Doctor
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