Health
Japanese Scientists Uncover Biological Evidence Behind Long COVID Brain Fog
In a groundbreaking discovery, scientists in Japan have identified what they describe as the first biological evidence explaining the cause of “brain fog” associated with Long COVID, shedding light on one of the most persistent and disabling aftereffects of the virus.
A research team from Yokohama City University, led by Professor Takuya Takahashi, found that people suffering from Long COVID show abnormally high activity of AMPA receptors — molecules in the brain essential for learning and memory. The findings, researchers say, indicate that Long COVID brain fog is not just a lingering symptom but a measurable molecular disorder.
“By applying our newly developed AMPA receptor PET imaging technology, we aim to provide a novel perspective and innovative solutions to the pressing medical challenge that is Long COVID,” said Professor Takahashi in a statement.
Brain fog — a broad term encompassing poor memory, slow thinking, and difficulty concentrating — is one of the most common symptoms reported by Long COVID patients. Studies estimate that more than 80 percent of people with the condition experience cognitive difficulties, often impairing their ability to work, study, or perform everyday tasks.
Until now, scientists have struggled to pinpoint a biological mechanism for the problem. While previous studies detected subtle structural changes in the brain, none had clearly linked them to specific molecular disruptions.
The Yokohama team focused on AMPA receptors (AMPARs), which act as key communication hubs between neurons. These receptors have been previously linked to mental health and neurological disorders such as depression, schizophrenia, and dementia. Using a newly developed technique known as K-2 AMPAR PET imaging, the researchers scanned the brains of 30 Long COVID patients and compared them with 80 healthy individuals.
The scans revealed that AMPAR density was significantly higher among those with Long COVID, and the greater the receptor activity, the more severe the cognitive symptoms reported by patients. The team also observed elevated levels of inflammation in affected individuals, suggesting that immune system overactivation in the brain may be driving the changes in receptor activity.
“Our findings clearly demonstrate that Long COVID brain fog should be recognized as a legitimate clinical condition,” said Takahashi. “This could encourage the healthcare industry to accelerate the development of diagnostic and therapeutic approaches for this disorder.”
According to the World Health Organization, around six in every 100 people who contract COVID-19 go on to develop post-COVID conditions. While the research remains in its early stages, experts say it opens the door to potential treatments aimed at reducing excessive AMPAR activity — a step that could one day help ease cognitive symptoms in millions of patients worldwide.
Health
World Cup Emotion Can Strain the Heart, Cardiologists Warn Fans at Risk
As the World Cup begins, medical experts are cautioning football fans with underlying heart conditions that the emotional intensity of matches can place unexpected strain on the cardiovascular system.
Cardiologists say that the excitement, tension, and anxiety generated during high-stakes games can trigger physical reactions similar to intense exercise, raising heart rate, blood pressure, and stress hormones.
“Intense emotions, whether positive or negative, can act as ‘precipitating risk factors’ for cardiovascular events such as heart attack,” said Paola Santalucia, a cardiologist and board member of the European Heart Network.
She explained that moments of extreme excitement, such as a decisive penalty shootout or a last-minute goal, may pose risks for people already living with heart disease. Those with additional risk factors, including hypertension, obesity, or smoking habits, are also advised to be cautious during emotionally charged matches.
Research using wearable devices has shown that during major football events, some fans experience heart rates climbing as high as 150 beats per minute. That level is comparable to sprinting and reflects how strongly the body reacts to emotional stress.
A study examining supporters during the 2025 German Cup final found that even watching from home can significantly affect physiological responses. “They still had an increase in heart rate that compares to walking, even though they didn’t walk,” said Christian Deutscher, professor of sports economics at Bielefeld University and co-author of the study.
He noted that the most intense reactions often occur not during goals themselves, but during moments of uncertainty such as VAR checks, penalty shootouts, or shots striking the post. These unpredictable situations, he said, are what drive the strongest emotional and physical responses among fans.
Deutscher also pointed out that stadium spectators may experience even greater strain due to environmental factors such as heat and alcohol consumption.
However, experts emphasize that football itself is not inherently dangerous. Instead, it is the body’s natural response to excitement that can create temporary stress.
“The adrenergic stimulation is at its max: extreme high blood pressure, high heart rate, and adrenaline, cortisol, skyrocketing,” said Dan Atar, professor of cardiology at Oslo University Hospital. In rare cases, he added, this surge can contribute to the rupture of arterial plaque in vulnerable individuals, potentially leading to a heart attack.
Atar stressed that such events can occur in everyday situations as well, including physical exertion like shoveling snow. “It is in no way dangerous to watch a football game,” he said. “All this is physiologic. It’s not dangerous to be excited.”
Still, he acknowledged that combining emotional stress with alcohol, heat, and pre-existing conditions can increase risk for some viewers.
Doctors advise those at higher risk to continue prescribed medications, limit alcohol intake, avoid smoking, and watch for warning signs such as chest pain or irregular heartbeat.
“The key message is not to avoid enjoying the match, but to do so with moderation and awareness,” Santalucia said.
Health
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Health
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