Health
Drug-Resistant ‘Nightmare Bacteria’ Infections Surge Across US, CDC Warns
Drug-resistant infections linked to so-called “nightmare bacteria” are rising sharply in the United States, with rates climbing nearly 70 percent between 2019 and 2023, according to new data from the Centers for Disease Control and Prevention (CDC).
The surge is being driven by bacteria carrying the NDM gene, which renders many treatments ineffective. Once considered rare and primarily associated with patients who had received medical care abroad, these infections are now spreading more widely across the US. CDC researchers published their findings Monday in the Annals of Internal Medicine.
The study found that cases of carbapenem-resistant bacterial infections — resistant even to last-resort antibiotics — rose from fewer than 2 per 100,000 people in 2019 to more than 3 per 100,000 in 2023, a 69 percent increase. But infections specifically caused by NDM-producing bacteria surged more than fivefold over the same period, from 0.25 to about 1.35 cases per 100,000.
“The rise of NDMs in the US is a grave danger and very worrisome,” said David Weiss, an infectious disease researcher at Emory University. He warned that many people may be carrying the bacteria unknowingly, raising the risk of community spread.
The threat extends to common illnesses long considered easy to treat. “Infections like urinary tract infections could become chronic problems,” said Dr. Maroya Walters, one of the study’s authors.
Currently, only two antibiotics are effective against NDM-linked infections, and both are costly treatments that must be administered intravenously.
Experts say the rise is partly linked to widespread antibiotic use during the COVID-19 pandemic. “We know that there was a huge surge in antibiotic use during the pandemic, so this likely is reflected in increasing drug resistance,” said Dr. Jason Burnham, a researcher at Washington University.
Antimicrobial resistance develops when bacteria and fungi evolve to withstand drugs designed to kill them. Misuse of antibiotics — such as taking unnecessary prescriptions or not completing a prescribed course — has been a key driver, making pathogens harder to treat over time.
CDC researchers analyzed data from 29 states that routinely test and report cases of carbapenem-resistant infections. In 2023, they documented 4,341 such cases, including 1,831 involving NDM. The report did not specify how many patients died.
However, the CDC stressed that the findings likely underestimate the true extent of the problem. Major states including California, Florida, New York, and Texas were not part of the dataset, and many hospitals lack the resources to conduct the genetic testing needed to detect resistance.
A separate CDC report published in June had already flagged a sharp rise in NDM cases in New York City between 2019 and 2024, reinforcing concerns about a growing national health threat.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
Europe Records Sharp Rise in Sexually Transmitted Infections, ECDC Warns
Health
White House Rejects Report It Blocked Return of Ebola-Infected US Doctor
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