Health
Drug-Resistant ‘Nightmare Bacteria’ Infections Surge Across US, CDC Warns
Drug-resistant infections linked to so-called “nightmare bacteria” are rising sharply in the United States, with rates climbing nearly 70 percent between 2019 and 2023, according to new data from the Centers for Disease Control and Prevention (CDC).
The surge is being driven by bacteria carrying the NDM gene, which renders many treatments ineffective. Once considered rare and primarily associated with patients who had received medical care abroad, these infections are now spreading more widely across the US. CDC researchers published their findings Monday in the Annals of Internal Medicine.
The study found that cases of carbapenem-resistant bacterial infections — resistant even to last-resort antibiotics — rose from fewer than 2 per 100,000 people in 2019 to more than 3 per 100,000 in 2023, a 69 percent increase. But infections specifically caused by NDM-producing bacteria surged more than fivefold over the same period, from 0.25 to about 1.35 cases per 100,000.
“The rise of NDMs in the US is a grave danger and very worrisome,” said David Weiss, an infectious disease researcher at Emory University. He warned that many people may be carrying the bacteria unknowingly, raising the risk of community spread.
The threat extends to common illnesses long considered easy to treat. “Infections like urinary tract infections could become chronic problems,” said Dr. Maroya Walters, one of the study’s authors.
Currently, only two antibiotics are effective against NDM-linked infections, and both are costly treatments that must be administered intravenously.
Experts say the rise is partly linked to widespread antibiotic use during the COVID-19 pandemic. “We know that there was a huge surge in antibiotic use during the pandemic, so this likely is reflected in increasing drug resistance,” said Dr. Jason Burnham, a researcher at Washington University.
Antimicrobial resistance develops when bacteria and fungi evolve to withstand drugs designed to kill them. Misuse of antibiotics — such as taking unnecessary prescriptions or not completing a prescribed course — has been a key driver, making pathogens harder to treat over time.
CDC researchers analyzed data from 29 states that routinely test and report cases of carbapenem-resistant infections. In 2023, they documented 4,341 such cases, including 1,831 involving NDM. The report did not specify how many patients died.
However, the CDC stressed that the findings likely underestimate the true extent of the problem. Major states including California, Florida, New York, and Texas were not part of the dataset, and many hospitals lack the resources to conduct the genetic testing needed to detect resistance.
A separate CDC report published in June had already flagged a sharp rise in NDM cases in New York City between 2019 and 2024, reinforcing concerns about a growing national health threat.
Health
World Cup Emotion Can Strain the Heart, Cardiologists Warn Fans at Risk
As the World Cup begins, medical experts are cautioning football fans with underlying heart conditions that the emotional intensity of matches can place unexpected strain on the cardiovascular system.
Cardiologists say that the excitement, tension, and anxiety generated during high-stakes games can trigger physical reactions similar to intense exercise, raising heart rate, blood pressure, and stress hormones.
“Intense emotions, whether positive or negative, can act as ‘precipitating risk factors’ for cardiovascular events such as heart attack,” said Paola Santalucia, a cardiologist and board member of the European Heart Network.
She explained that moments of extreme excitement, such as a decisive penalty shootout or a last-minute goal, may pose risks for people already living with heart disease. Those with additional risk factors, including hypertension, obesity, or smoking habits, are also advised to be cautious during emotionally charged matches.
Research using wearable devices has shown that during major football events, some fans experience heart rates climbing as high as 150 beats per minute. That level is comparable to sprinting and reflects how strongly the body reacts to emotional stress.
A study examining supporters during the 2025 German Cup final found that even watching from home can significantly affect physiological responses. “They still had an increase in heart rate that compares to walking, even though they didn’t walk,” said Christian Deutscher, professor of sports economics at Bielefeld University and co-author of the study.
He noted that the most intense reactions often occur not during goals themselves, but during moments of uncertainty such as VAR checks, penalty shootouts, or shots striking the post. These unpredictable situations, he said, are what drive the strongest emotional and physical responses among fans.
Deutscher also pointed out that stadium spectators may experience even greater strain due to environmental factors such as heat and alcohol consumption.
However, experts emphasize that football itself is not inherently dangerous. Instead, it is the body’s natural response to excitement that can create temporary stress.
“The adrenergic stimulation is at its max: extreme high blood pressure, high heart rate, and adrenaline, cortisol, skyrocketing,” said Dan Atar, professor of cardiology at Oslo University Hospital. In rare cases, he added, this surge can contribute to the rupture of arterial plaque in vulnerable individuals, potentially leading to a heart attack.
Atar stressed that such events can occur in everyday situations as well, including physical exertion like shoveling snow. “It is in no way dangerous to watch a football game,” he said. “All this is physiologic. It’s not dangerous to be excited.”
Still, he acknowledged that combining emotional stress with alcohol, heat, and pre-existing conditions can increase risk for some viewers.
Doctors advise those at higher risk to continue prescribed medications, limit alcohol intake, avoid smoking, and watch for warning signs such as chest pain or irregular heartbeat.
“The key message is not to avoid enjoying the match, but to do so with moderation and awareness,” Santalucia said.
Health
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Health
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