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Novo Nordisk Shares Rise Despite 2025 Outlook Downgrade Amid Weight-Loss Drug Market Pressures

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Shares in Novo Nordisk surged on Wednesday after the Danish pharmaceutical giant posted stronger-than-expected first-quarter earnings, even as it lowered its growth outlook for 2025 due to mounting competition in the weight-loss drug market.

The company, best known for its diabetes and obesity treatments, reported a 20% year-on-year rise in net profit to 38.8 billion Danish kroner (€5.2 billion), with net sales up 18% to 78.1 billion kroner (€10.5 billion). Both figures exceeded analyst expectations, driven by robust demand for obesity and diabetes medications.

Despite the upbeat results, Novo Nordisk cut its full-year guidance. The firm now expects 2025 sales growth of 13–21%, down from its earlier projection, and operating profit growth between 16–24% at constant exchange rates—both lowered by several percentage points.

We have reduced our full-year outlook due to lower-than-planned branded GLP-1 penetration, which is impacted by the rapid expansion of compounding in the US,” CEO Lars Fruergaard Jørgensen said in a statement. “We are actively focused on preventing unlawful and unsafe compounding and on efforts to expand patient access to our GLP-1 treatments.”

Still, shares rose 4.4% at the opening of European trading, though the stock remains down 26% since the start of the year. In contrast, main U.S. competitor Eli Lilly has seen a more stable stock performance in 2025.

A key pressure point for Novo Nordisk is the U.S. market, where demand for GLP-1-based weight-loss treatments like Wegovy has outpaced supply. Under FDA policy, compounding pharmacies were permitted to produce alternative versions of drugs in short supply, allowing smaller rivals to offer cheaper options. Although the FDA declared shortages over earlier this year, it granted a grace period until May 22 for compounded versions to remain in circulation.

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In response, Novo Nordisk slashed Wegovy’s price by more than half on its online platform, NovoCare, mirroring similar price cuts by Eli Lilly.

In its outlook, Novo Nordisk highlighted the continued global rollout of Wegovy, noting there are an estimated one billion people living with obesity worldwide, yet only a fraction are receiving treatment. CFO Karsten Munk Knudsen said he expects Wegovy sales to pick up further in the third quarter.

Meanwhile, the company announced the completion of its REDEFINE 2 trial for its next-generation drug, CagriSema, which showed a 15.7% weight reduction. While the results fell short of the 25% reduction some had hoped for, Novo Nordisk aims to file for regulatory approval early next year.

The company also said it has filed for U.S. approval of a new oral formulation of semaglutide, which could become the first oral GLP-1 drug for obesity treatment.

Despite market headwinds, Novo Nordisk remains optimistic about future growth in a highly competitive but fast-expanding global obesity market.

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IMF Warns of Trade Tensions and AI Market Risks as Global Growth Remains Resilient

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The International Monetary Fund (IMF) has highlighted trade tensions and a potential slowdown in the artificial intelligence (AI) sector as major risks to the global economy, even as it described growth prospects for 2026 as “resilient.”

In its latest World Economic Outlook, the IMF projected global growth at 3.3% this year, up from its previous forecast of 3.1%, before easing slightly to 3.2% in 2027. IMF chief economist Pierre Olivier Gourinchas said the world economy has been “shaking off the trade disruptions of 2025” and emerging stronger than expected, despite recent threats from US President Donald Trump to impose tariffs on eight European countries opposed to his Greenland proposal.

While AI-driven investment has supported growth, the IMF warned that overly optimistic expectations could trigger a market correction, with even a mild downturn affecting household wealth and corporate investment. “It doesn’t take as much of a market reaction to have an impact on people’s wealth relative to their income, so they start cutting consumption and businesses change their investment plans,” Gourinchas said.

Trade tensions remain another concern. The IMF cautioned that political or geopolitical conflicts could disrupt supply chains, commodity prices, and financial markets, weighing on global activity.

The report also stressed the importance of central bank independence for macroeconomic stability and long-term growth. Maintaining legal and operational independence allows central banks to anchor inflation expectations and avoid fiscal pressures. Gourinchas noted that pressures on central banks, particularly in countries with high borrowing needs, can lead to higher inflation and borrowing costs over time.

The IMF’s forecast for the United Kingdom showed slightly stronger growth than previously expected. The UK economy grew by 1.4% in 2025, up from a prior estimate of 1.3%, and is expected to expand 1.3% this year, making it the third-fastest growing G7 economy after the US and Canada. Growth is projected to rise to 1.5% in 2027. Chancellor Rachel Reeves described the figures as evidence that the UK is “on course to be the fastest growing European G7 economy this year and next,” while shadow chancellor Sir Mel Stride dismissed the increase as modest.

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Inflation is expected to ease globally, falling from 4.1% in 2025 to 3.8% in 2026 and 3.4% in 2027. In the UK, inflation is projected to return to the 2% target by the end of the year as a weakening labour market keeps wage growth subdued.

Gourinchas said challenges to central bank independence, such as political pressure to keep interest rates low, have emerged in several countries. He warned that undermining central banks tends to produce inflation and higher borrowing costs, calling it “self-defeating.”

The IMF report comes amid heightened scrutiny of global central banks, including the US Federal Reserve, following recent legal investigations and political disputes, underscoring the fund’s emphasis on safeguarding institutional independence as a cornerstone of economic stability.

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China Reports 5% Economic Growth Amid Record Trade Surplus and Domestic Challenges

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China said its economy grew by 5% in 2025, meeting the government’s official target despite a slowdown to 4.5% in the final quarter of the year, driven in part by a record trade surplus.

The world’s second-largest economy faced a year of weak domestic spending, a prolonged property market downturn, and ongoing uncertainty from US tariff policies. Analysts describe the figures as reflecting a “two-speed economy,” with manufacturing and exports supporting growth while consumer spending remains cautious and the housing sector continues to weigh on overall activity.

Some economists question the official numbers. Zichun Huang, a China economist at Capital Economics, said the figures “overstate the pace of economic expansion” by at least 1.5 percentage points, citing weak investment and subdued household consumption.

Data released on Monday also highlighted China’s deepening demographic challenges. The number of births fell to 7.9 million in 2025, the lowest since records began in 1949. The country’s population declined for the fourth consecutive year, dropping 3.4 million to 1.4 billion. Experts warn that falling birth rates could reduce demand for housing and consumer goods, adding pressure to an already struggling property market.

The property sector remains a key concern. House prices continued to fall in December, dropping 2.7% year-on-year, marking the sharpest decline in five months. Property investment fell 17.2% for the year. The prolonged slump affects construction activity, household wealth, and local government finances, leaving millions of homeowners with unfinished or devalued properties.

Retail sales rose only 0.9% in December, the slowest pace in three years, while factory output increased 5.2%, slightly up from November’s 4.8%. Analysts say export growth and manufacturing output are currently propping up the economy, while domestic consumption remains weak.

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China recorded a record trade surplus of $1.19 trillion in 2025, driven by strong exports outside the United States. Alicia Garcia-Herrero, chief economist for Asia Pacific at Natixis, warned that “China is effectively pushing growth through exports at a loss,” a strategy that may not be sustainable as it can undermine profits and long-term expansion.

Speaking on Monday, Kang Yi, head of China’s National Bureau of Statistics, acknowledged the economy “faces problems and challenges, including strong supply and weak demand,” but said China can “maintain stable, sound growth momentum this year.”

Analysts say China faces a delicate balancing act. Policymakers aim to support growth through targeted stimulus and boost consumer confidence while avoiding excessive debt and reducing reliance on exports amid ongoing global trade tensions, including uncertainty over US tariff policies.

While China officially met its growth target, the underlying economic picture suggests caution. Weak domestic demand, a fragile property market, and demographic shifts indicate that sustaining long-term growth will require careful management of both fiscal and monetary policy.

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Stablecoins Hit Record Transaction Volumes as Governments and Firms Embrace Digital Payments

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Stablecoins recorded a historic year in 2025, as both governments and private companies encouraged their adoption across financial systems worldwide. Total transaction volumes surged 72 percent over the year, reaching $33 trillion (€28 trillion), according to Artemis Analytics.

Unlike traditional cryptocurrencies, stablecoins are designed to maintain a stable value by pegging themselves to real-world assets, most commonly the US dollar. They are fully backed by reserves such as treasury bills or cash, allowing holders to redeem them on a 1:1 basis. More than 90 percent of stablecoins in circulation are dollar-pegged, with Tether’s USDT holding a market cap of $186 billion (€160 billion) and Circle’s USDC at $75 billion (€65 billion). In 2025, Circle processed $18.3 trillion (€15.7 trillion) in transactions, while USDT handled $13.3 trillion (€11.4 trillion).

A report by venture capital firm a16z highlighted that stablecoins facilitated at least $9 trillion (€7.7 trillion) in “real” user payments last year, an 87 percent increase from 2024. Analysts noted that this volume is more than five times that of PayPal and over half of Visa’s annual transaction throughput.

Central banks have also taken notice of the growing adoption of digital currencies. In addition to private stablecoins, several governments are developing central bank digital currencies (CBDCs). China’s digital yuan has been in pilot phases since 2019, while the European Central Bank is preparing to issue a digital euro, targeting 2029 for the first launch. McKinsey data shows that cash still accounts for 46 percent of global payments, but non-digital transactions are declining, particularly in developed countries with strong digital infrastructure.

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The United States has taken a different approach. In January 2025, President Donald Trump signed an executive order blocking any government action to issue CBDCs, clearing the way for private stablecoins to dominate. Trump later approved the GENIUS Act, which established a comprehensive regulatory framework requiring stablecoin issuers to maintain full 1:1 reserve backing with liquid assets. The framework aims to ensure stability and encourage confidence in the use of digital dollars.

In Europe, stablecoin adoption continues under the EU’s Markets in Crypto-Assets (MiCA) regulation. By July 2026, firms must secure a Crypto-Asset Service Provider (CASP) licence to operate legally. Payments company Ingenico recently partnered with WalletConnect to allow merchants to accept stablecoins, including USDC and EURC, using existing terminals. WalletConnect’s CEO, Jess Houlgrave, said that while MiCA is not perfect, “some regulatory clarity is better than none,” and called for uniform enforcement to prevent regulatory shopping.

Crossmint, a stablecoin infrastructure provider, also secured a MiCA licence in Spain this week. General counsel Miguel Zapatero noted that obtaining the licence is costly but increases credibility, with other regulators often fast-tracking approvals for licensed firms.

As private stablecoins gain traction and CBDCs slowly roll out, 2025 marked a turning point in the integration of digital currencies into mainstream financial systems, showing strong institutional and corporate adoption while highlighting the global push for regulatory clarity.

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