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Novo Nordisk Shares Rise Despite 2025 Outlook Downgrade Amid Weight-Loss Drug Market Pressures

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Shares in Novo Nordisk surged on Wednesday after the Danish pharmaceutical giant posted stronger-than-expected first-quarter earnings, even as it lowered its growth outlook for 2025 due to mounting competition in the weight-loss drug market.

The company, best known for its diabetes and obesity treatments, reported a 20% year-on-year rise in net profit to 38.8 billion Danish kroner (€5.2 billion), with net sales up 18% to 78.1 billion kroner (€10.5 billion). Both figures exceeded analyst expectations, driven by robust demand for obesity and diabetes medications.

Despite the upbeat results, Novo Nordisk cut its full-year guidance. The firm now expects 2025 sales growth of 13–21%, down from its earlier projection, and operating profit growth between 16–24% at constant exchange rates—both lowered by several percentage points.

We have reduced our full-year outlook due to lower-than-planned branded GLP-1 penetration, which is impacted by the rapid expansion of compounding in the US,” CEO Lars Fruergaard Jørgensen said in a statement. “We are actively focused on preventing unlawful and unsafe compounding and on efforts to expand patient access to our GLP-1 treatments.”

Still, shares rose 4.4% at the opening of European trading, though the stock remains down 26% since the start of the year. In contrast, main U.S. competitor Eli Lilly has seen a more stable stock performance in 2025.

A key pressure point for Novo Nordisk is the U.S. market, where demand for GLP-1-based weight-loss treatments like Wegovy has outpaced supply. Under FDA policy, compounding pharmacies were permitted to produce alternative versions of drugs in short supply, allowing smaller rivals to offer cheaper options. Although the FDA declared shortages over earlier this year, it granted a grace period until May 22 for compounded versions to remain in circulation.

In response, Novo Nordisk slashed Wegovy’s price by more than half on its online platform, NovoCare, mirroring similar price cuts by Eli Lilly.

In its outlook, Novo Nordisk highlighted the continued global rollout of Wegovy, noting there are an estimated one billion people living with obesity worldwide, yet only a fraction are receiving treatment. CFO Karsten Munk Knudsen said he expects Wegovy sales to pick up further in the third quarter.

Meanwhile, the company announced the completion of its REDEFINE 2 trial for its next-generation drug, CagriSema, which showed a 15.7% weight reduction. While the results fell short of the 25% reduction some had hoped for, Novo Nordisk aims to file for regulatory approval early next year.

The company also said it has filed for U.S. approval of a new oral formulation of semaglutide, which could become the first oral GLP-1 drug for obesity treatment.

Despite market headwinds, Novo Nordisk remains optimistic about future growth in a highly competitive but fast-expanding global obesity market.

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Japan’s Economy Contracts as U.S. Tariffs Hit Exports, Posing Early Test for New Prime Minister

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Japan’s economy recorded a sharp slowdown in the July–September quarter, contracting for the first time in a year and a half as U.S. trade tariffs weighed heavily on exports. Government figures released on Monday showed an annualised decline of 1.8%, driven largely by weakened overseas demand after Washington imposed new duties on Japanese goods.

While the downturn was significant, it was not as steep as the 2.6% drop projected by economists. On a quarter-to-quarter basis, gross domestic product slipped 0.4%, ending six straight quarters of expansion and signalling a tougher economic landscape for recently appointed Prime Minister Sanae Takaichi.

Exports recorded one of the sharpest declines of the quarter, falling 1.2% from the previous period. The government noted that some firms rushed shipments earlier in the year to get ahead of tariff deadlines, which boosted earlier export data but resulted in weaker numbers for the autumn quarter. On an annualised basis, exports tumbled 4.5%.

Imports were slightly lower as well, dipping 0.1%, while private consumption — a key driver of the domestic economy — inched up by the same margin. Economists say the modest rise in household spending is not enough to offset the strain placed on the country’s major industries.

The tariff pressures stem from measures introduced by U.S. President Donald Trump, who has implemented a 15% duty on nearly all Japanese imports. Although this marks a reduction from the previous 25% rate, the impact has been severe for Japan’s export-heavy economy. Automakers such as Toyota Motor Corp. have long been central to Japan’s global trade profile, though many have built factories abroad to reduce exposure to such trade barriers.

The latest GDP results add to the mounting challenges facing Takaichi, who assumed office in October. Alongside the economic risks, her government is navigating rising diplomatic tensions with China. Earlier this month, the prime minister stated that Japan may consider military action if Beijing launches an attack on Taiwan, prompting sharp reactions from Chinese officials.

Talks between diplomats from both countries are scheduled to take place on Tuesday, with economic stability and regional security expected to dominate the agenda.

The combination of trade pressures, geopolitical strain and a fragile domestic recovery places Japan at a sensitive moment, with policymakers now under heightened pressure to stabilise growth in the months ahead.

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Global Stocks Fall as Tech Valuations and Fed Rate Uncertainty Weigh on Markets

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Global equities declined on Friday as investors grew cautious over high valuations in technology and AI sectors, coupled with uncertainty about whether the US Federal Reserve will deliver further interest-rate cuts. European markets opened sharply lower following losses in Asian shares and a drop on Wall Street on Thursday.

“Markets are down across the board as investors fret about cracks in the narrative that’s driven the mother of all tech rallies over the past few years,” said Dan Coatsworth, head of markets at AJ Bell. He highlighted concerns over elevated equity prices and heavy spending on AI amid signs of a fragile labor market.

In Europe, UK government bond yields surged after reports that Chancellor Rachel Reeves had abandoned plans to raise income taxes in this month’s Autumn Budget, raising questions about a potential fiscal shortfall. The ten-year gilt yield climbed above 4.54% before easing slightly. Bank shares were among the worst performers on the FTSE 100, which fell more than 1.1% by 11:00 CET. Other European indices also declined, with the Stoxx 600 down nearly 1%, Germany’s DAX off 0.7%, France’s CAC 40 down 0.7%, Madrid’s benchmark losing 1.2% and Milan’s index down 1%.

Some companies bucked the overall trend. Luxury group Richemont rose 7.5% after exceeding first-half profit expectations, and Siemens Energy gained more than 10% after raising its 2028 financial targets. In contrast, Ubisoft delayed its six-month financial report, triggering a suspension in trading after an earlier drop of over 8%.

Wall Street had suffered a sharp decline on Thursday, with the S&P 500 and the Dow Jones Industrial Average both down 1.7%, and the Nasdaq falling 2.3%. Technology and AI-linked stocks experienced heavy selling, with Nvidia down 3.6%, Super Micro Computer off 7.4%, Palantir down 6.5%, Broadcom losing 4.3%, and Oracle sliding more than 4%. The sector’s rapid gains this year have drawn comparisons with the dot-com boom, prompting questions about the sustainability of current valuations.

Asian markets also reflected the cautious mood. China reported factory output growth at 4.9% year-on-year in October, the slowest in 14 months and below expectations. Weakness in fixed-asset investment, especially in the property sector, added to concerns. South Korea’s Kospi fell 3.8%, with Samsung Electronics down 5.5% and SK Hynix off 8.5%. Taiwan’s Taiex dropped 1.8%, Japan’s Nikkei 225 lost nearly 1.8%, and Hong Kong’s Hang Seng slipped 2%. The Shanghai Composite declined 1%.

Oil prices rose, with Brent crude up 1.6% at $63.99 per barrel and West Texas Intermediate climbing 1.8% to $59.76. The dollar strengthened slightly against the yen at ¥154.55, while the euro traded at $1.1637.

Investors continue to weigh the risks of stretched valuations in technology against uncertain monetary policy, leaving markets cautious as they head into the final months of 2025.

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Eurozone Economy Shows Weak Growth as Business Activity Faces Mixed Signals

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The eurozone’s economy expanded only slightly in the third quarter of 2025, with GDP rising 0.2% compared with the previous quarter, while the broader European Union recorded a marginal 0.3% gain, according to a flash estimate from Eurostat. Year-on-year, growth stood at 1.3% in the eurozone and 1.5% across the EU, reflecting continued but fragile expansion.

Sweden posted the strongest quarterly increase at 1.1%, followed by Portugal at 0.8% and Czechia at 0.7%. In contrast, Lithuania’s economy contracted by 0.2%, while Ireland and Finland each recorded a 0.1% decline. Analysts said the data shows that economic momentum is uneven across member states, with some countries gaining ground while others struggle to maintain growth.

The labour market remained broadly stable. The eurozone unemployment rate held at 6.3% in September, unchanged from both August 2025 and the same month last year. Including non-eurozone EU members, the jobless rate stood at 6.0%, slightly higher than 5.9% a year earlier. Overall, approximately 13.25 million people were unemployed in the EU, including around 11 million within the eurozone. Youth unemployment remained elevated at 14.8% in the EU and 14.4% in the eurozone. Women’s unemployment was slightly higher than men’s at 6.5% versus 6.2%.

Eurostat also reported mixed signals in business activity. New company registrations across the EU rose 4.0% in the third quarter. The strongest growth came in tech, information and communications (+6.0%), construction (+5.9%) and transport (+5.5%). At the same time, bankruptcies climbed 4.4% quarter-on-quarter, with the sharpest increases in accommodation and food services (+20.7%), transport (+18.7%) and financial services (+14.1%). In contrast, bankruptcies declined in the information and communications sector (-4.8%), construction (-3.1%) and general industrial businesses (-0.1%).

The contrasting trends in new business registrations and insolvencies suggest that while entrepreneurship remains active, certain consumer-facing and logistics sectors continue to face financial pressures. Analysts said the sharp rise in bankruptcies in accommodation, food services and transport may reflect higher operating costs and tighter financing conditions, even as other industries expand.

Overall, the data paints a picture of a European economy advancing cautiously. Growth remains modest, unemployment is largely stable, and the business environment shows both opportunities and risks. Policymakers are likely to monitor these developments closely as they assess measures to support economic resilience and sectoral stability across the eurozone.

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