Business
Novo Nordisk Shares Plunge 20% After Disappointing CagriSema Trial Results
Novo Nordisk experienced its sharpest one-day decline in history on Friday as shares of the Danish pharmaceutical giant plummeted 20% following underwhelming trial results for its new obesity drug, CagriSema. The drop wiped out €90 billion in market valuation, significantly impacting the year-to-date performance of Europe’s largest company, which is now down 16% in 2024.
CagriSema Misses Expectations
The phase 3 trial for CagriSema revealed a weight loss of 22.7% over 68 weeks, below the projected 25% benchmark. The figure fell further to 20.4% among patients who did not strictly adhere to the treatment regimen. The results raised concerns about Novo Nordisk’s competitiveness in the rapidly growing obesity and diabetes drug market.
Eli Lilly, Novo Nordisk’s primary U.S.-based rival, reported a 24% weight loss in September with its latest drug, retatrutide. Eli Lilly’s stock surged 10% before closing 1.35% higher on Friday and has gained 32% this year, a stark contrast to Novo Nordisk’s performance.
Adding to the disappointment, only 57% of CagriSema trial participants reached the highest dose, compared to 83% for cagrilintide and 70% for semaglutide in previous studies. Concerns about the drug’s side effects and market positioning have tempered investor expectations.
“Based on insights from the REDEFINE 1 trial, we will explore additional weight loss potential for CagriSema,” said Martin Holst Lange, Novo Nordisk’s executive vice president for Development. Results from a second phase 3 trial, REDEFINE 2, are expected in the first half of 2025.
Heightened Competition in the Weight-Loss Market
The global market for weight-loss and diabetes drugs, including GLP-1 treatments, is projected to grow to between $150 billion and $200 billion by 2030. Novo Nordisk’s weight-loss drug Wegovy and diabetes treatment Ozempic accounted for 61% of the company’s sales in the first nine months of 2024.
Eli Lilly has emerged as a formidable competitor with its weight-loss drugs Zepbound and Mounjaro. The U.S.-based company, valued at $691 billion (€662 billion), has positioned itself as a market leader, with analysts expecting the two firms to evenly split the weight-loss market by the end of 2024.
Future Challenges for Novo Nordisk
Novo Nordisk faces mounting pressure to expedite next-generation drug development as the patent for Wegovy is set to expire in the early 2030s. The disappointing results for CagriSema have raised doubts about the company’s ability to sustain its dominance in the sector.
The U.S. remains Novo Nordisk’s largest market, accounting for 35% of its diabetes drug sales as of August 2024. While the company’s valuation peaked in June, Friday’s market reaction underscores the challenges it faces in retaining its competitive edge in a rapidly evolving industry.
Business
Fitch Cuts France’s Debt Outlook to Negative Amid Budget Deadlock and Weak Growth
Credit rating agency Fitch has revised France’s sovereign debt outlook from stable to negative while maintaining its rating at A+, citing weaker economic growth, rising borrowing costs and concerns over the country’s ability to reduce its public deficit.
The decision increases pressure on the French government to secure approval for its 2027 budget by the end of the year, as political divisions and an approaching presidential election complicate efforts to restore public finances.
Fitch’s announcement on Friday followed figures from the national statistics institute Insee showing that France’s gross domestic product contracted by 0.1% in the third quarter of 2026. The economy had stagnated in the second quarter after shrinking by 0.2% in the first three months of the year.
The agency pointed to persistent political fragmentation and a difficult social climate, including mass protests, as factors weakening confidence in the government’s ability to deliver lasting fiscal improvements.
Economy and Finance Minister Roland Lescure said he took note of Fitch’s decision, describing the adoption of a responsible budget before the end of the year as an absolute necessity.
The government aims to reduce the budget deficit to 5% of gross domestic product, while maintaining a path towards fiscal consolidation. Lescure said a clear budget was needed to give businesses and investors greater certainty in an uncertain international environment.
Earlier on Friday, he described the French economy as being at a standstill and warned that the country could face serious difficulties if the proposed recovery budget was not adopted. He repeated that the deficit needed to be brought down to 5% or less.
However, securing parliamentary approval remains uncertain because President Emmanuel Macron’s government lacks a majority in the National Assembly. The approaching 2027 presidential election is also adding to political tensions.
Fitch expects the budget to be adopted despite the parliamentary deadlock, pointing to constitutional procedures available to the government. The agency said political debates ahead of the election had done little to strengthen its confidence in France’s ability to achieve a lasting reduction in the deficit and stabilise public debt.
One option available to the government is Article 49.3 of the French Constitution, which allows legislation to pass without a parliamentary vote unless lawmakers approve a motion of no confidence.
The government could also consider adopting the budget through ordinances, although this procedure has never been used to pass a national budget since the Fifth Republic was established in 1958.
Jérôme Mathis, an economics professor at Paris-Dauphine University, told Euronews that using ordinances could reduce uncertainty in the short term. However, he warned that such a move would not necessarily restore France’s long-term fiscal credibility.
The negative outlook signals increased concern over France’s financial position, although its A+ rating remains unchanged. The government’s ability to pass the 2027 budget and demonstrate credible deficit-reduction measures will be central to restoring confidence.
Business
Uzbekistan Launches Apple Pay and Google Pay Following Financial Sector Reforms
Uzbekistan has introduced Apple Pay and Google Pay, opening access to two major international digital payment platforms as the country moves to modernise its financial services sector.
The rollout follows regulatory changes to personal data laws and discussions between Uzbek officials and technology companies. The Central Bank of Uzbekistan has also confirmed that work is underway to extend the services to cards issued through domestic payment networks Uzcard and HUMO, although no launch date has been announced.
Saida Mirziyoyeva, head of the Presidential Administration, announced the availability of the services for locally issued cards on October 27. She had met Google Vice President Karan Bhatia in New York a month earlier to discuss technological cooperation and the conditions needed for international payment providers to operate in the country.
Banks included in the rollout
Before the launch, customers in Uzbekistan could use domestic mobile and contactless payment services, including HUMO Pay and UZCARD PAY, as well as QR code systems.
The introduction of Apple Pay and Google Pay gives eligible cardholders access to international platforms for mobile payments.
Apple Pay initially supports Visa and Mastercard cards issued by eight local banks and financial institutions: Uzum Bank, Orient Finans Bank, the National Bank of Uzbekistan, Kapitalbank, Hamkorbank, Ipak Yuli Bank, TBC Bank and Octobank. Uzum Bank and Hamkorbank currently support Visa cards only.
Google Pay is available for eligible cards from nine banks: AVO Bank, Octobank, Uzum Bank, TBC Bank, Aloqabank, Kapitalbank, Ipak Yuli Bank, the National Bank of Uzbekistan and Orient Finans Bank.
Customers have been advised to contact their banks to confirm which cards can be added to the services.
The Central Bank told Euronews that both platforms protect customers’ card information during transactions. Cashback offers and other benefits will depend on the conditions set by individual banks.
Changes to data protection rules
The launch follows amendments to Uzbekistan’s personal data legislation in March 2026, which eased restrictions on the processing and storage of certain types of personal information outside the country.
During her September meeting with Google’s Bhatia, Mirziyoyeva linked the regulatory changes to the arrival of international payment systems, saying they were creating wider opportunities for their use in Uzbekistan.
The discussions also covered cooperation in artificial intelligence, cybersecurity training and support for the country’s technology industry.
The development forms part of Uzbekistan’s broader efforts to strengthen its financial technology sector. In September, the Central Bank approved a National Fintech Strategy covering the 2026-2030 period.
The strategy aims to attract investment, expand cross-border payments, introduce Open Banking and improve connections between financial systems.
The planned inclusion of Uzcard and HUMO would extend access to the international payment platforms beyond customers using Visa and Mastercard, bringing more locally issued cards into the expanding digital payments market.
Business
AstraZeneca Third-Quarter Profit Jumps 23% as Drugmaker Plans $1.5 Billion in Annual Savings
AstraZeneca reported a 23 per cent increase in third-quarter net profit, supported by strong sales of its cancer medicines, as the British pharmaceutical company announced plans to save $1.5 billion annuAstraZeneca Third-Quarter Profit Jumps 23% as Drugmaker Plans $1.5 Billion in Annual Savings
ally and reinvest the funds in developing new treatments.
The company said on Friday that profit after tax reached $3.12 billion for the July to September period, compared with the same quarter a year earlier. The increase marked a stronger performance than the previous quarter, when net profit rose just over 2 per cent.
Revenue increased 7 per cent to $16.2 billion, while core earnings per share rose 17 per cent to $2.79. The earnings figure excludes certain items, including restructuring costs and the amortisation of acquired medicines.
Oncology remained AstraZeneca’s largest business, accounting for 48 per cent of total revenue. Sales in the division increased 17 per cent to $7.8 billion, supported by demand for lung cancer treatment Tagrisso and immunotherapy Imfinzi.
The company’s new cost-saving programme, named Reshaping for Sustainable Growth, is expected to generate $1.5 billion in annual savings. AstraZeneca said the funds would mainly support its research and development pipeline, which includes more than 180 projects.
The restructuring is expected to involve one-off charges of up to $2 billion and is scheduled to be largely completed by the end of 2029. The company did not announce any job cuts, although the changes could affect its workforce as resources are redirected across the business.
Chief Executive Pascal Soriot said AstraZeneca remained on course to achieve its long-term growth ambitions, pointing to late-stage drug candidates and the expansion of new technologies.
Pressure from generic medicines and China
The company’s growth came despite declining sales of some established medicines. Revenue from Farxiga, used to treat diabetes, heart and kidney disease, fell 25 per cent to $1.6 billion after generic alternatives entered the US market. Blood thinner Brilinta has also faced competition following the loss of patent protection.
AstraZeneca is also dealing with China’s volume-based procurement system, under which state purchasing programmes secure large orders from pharmaceutical companies in exchange for lower prices.
The drugmaker maintained its 2026 financial outlook, forecasting revenue growth in the mid-to-high single digits and an increase in core earnings per share in the low double digits, excluding currency movements.
It also reaffirmed its ambition to generate $80 billion in annual revenue by 2030, compared with nearly $59 billion in 2025. The company expects the US market to account for half of that target.
AstraZeneca has expanded its focus on the US, adding a direct share listing in New York in February, while also pledging to invest $15 billion in China by 2030.
The company said it had recorded 12 positive late-stage clinical trial results so far this year. Its development programme also includes a weight-loss treatment intended to compete with products such as Novo Nordisk’s Wegovy and Eli Lilly’s Mounjaro.
AstraZeneca shares rose more than 4.5 per cent in early trading on Friday following the results.
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