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Novo Nordisk Shares Plunge 20% After Disappointing CagriSema Trial Results

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Novo Nordisk experienced its sharpest one-day decline in history on Friday as shares of the Danish pharmaceutical giant plummeted 20% following underwhelming trial results for its new obesity drug, CagriSema. The drop wiped out €90 billion in market valuation, significantly impacting the year-to-date performance of Europe’s largest company, which is now down 16% in 2024.

CagriSema Misses Expectations

The phase 3 trial for CagriSema revealed a weight loss of 22.7% over 68 weeks, below the projected 25% benchmark. The figure fell further to 20.4% among patients who did not strictly adhere to the treatment regimen. The results raised concerns about Novo Nordisk’s competitiveness in the rapidly growing obesity and diabetes drug market.

Eli Lilly, Novo Nordisk’s primary U.S.-based rival, reported a 24% weight loss in September with its latest drug, retatrutide. Eli Lilly’s stock surged 10% before closing 1.35% higher on Friday and has gained 32% this year, a stark contrast to Novo Nordisk’s performance.

Adding to the disappointment, only 57% of CagriSema trial participants reached the highest dose, compared to 83% for cagrilintide and 70% for semaglutide in previous studies. Concerns about the drug’s side effects and market positioning have tempered investor expectations.

“Based on insights from the REDEFINE 1 trial, we will explore additional weight loss potential for CagriSema,” said Martin Holst Lange, Novo Nordisk’s executive vice president for Development. Results from a second phase 3 trial, REDEFINE 2, are expected in the first half of 2025.

Heightened Competition in the Weight-Loss Market

The global market for weight-loss and diabetes drugs, including GLP-1 treatments, is projected to grow to between $150 billion and $200 billion by 2030. Novo Nordisk’s weight-loss drug Wegovy and diabetes treatment Ozempic accounted for 61% of the company’s sales in the first nine months of 2024.

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Eli Lilly has emerged as a formidable competitor with its weight-loss drugs Zepbound and Mounjaro. The U.S.-based company, valued at $691 billion (€662 billion), has positioned itself as a market leader, with analysts expecting the two firms to evenly split the weight-loss market by the end of 2024.

Future Challenges for Novo Nordisk

Novo Nordisk faces mounting pressure to expedite next-generation drug development as the patent for Wegovy is set to expire in the early 2030s. The disappointing results for CagriSema have raised doubts about the company’s ability to sustain its dominance in the sector.

The U.S. remains Novo Nordisk’s largest market, accounting for 35% of its diabetes drug sales as of August 2024. While the company’s valuation peaked in June, Friday’s market reaction underscores the challenges it faces in retaining its competitive edge in a rapidly evolving industry.

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Uzbekistan Accelerates Energy Expansion With Renewables, Grid Upgrades and First Nuclear Plant

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Uzbekistan is embarking on a major expansion of its electricity sector, aiming to increase annual power generation from 82 billion kilowatt-hours to more than 120 billion kilowatt-hours over the next five years as the country responds to rising demand from industry, population growth and emerging digital industries.

The ambitious target highlights the government’s drive to strengthen energy security while gradually reducing dependence on fossil fuels. Officials see the power sector as a key area for investment, with renewable energy, electricity transmission and nuclear power expected to play central roles in the country’s long-term strategy.

Speaking at the Tashkent International Investment Forum, President Shavkat Mirziyoyev said renewable sources are expected to generate 54% of Uzbekistan’s electricity by 2030. He noted that the country has already attracted nearly $6 billion in foreign investment for green energy projects and plans to invest another $4 billion in modernising electricity transmission networks.

Mirziyoyev also encouraged investment in solar and wind farms, battery energy storage systems, upgraded power grids and green-powered data centres, linking energy development with Uzbekistan’s industrial and digital transformation goals.

International financial institutions are already backing several major projects. In 2025, the European Bank for Reconstruction and Development (EBRD) invested nearly $2 billion across 120 projects in Central Asia and Mongolia, with more than $1 billion directed toward Uzbekistan. More than half of the bank’s regional investments were classified as green initiatives, while about one-third supported sustainable infrastructure.

Among its projects in Uzbekistan is a $142 million financing package for a combined one-gigawatt solar photovoltaic plant and a battery storage system with a capacity of 1,336 megawatt-hours, developed alongside ACWA Power. The EBRD has also arranged financing of up to $195.5 million for a 300-megawatt solar facility and a 75-megawatt-hour battery storage project being developed by Masdar in the Kashkadarya region.

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EBRD Managing Director for Central Asia and Mongolia Huseyin Ozhan said expanding energy capacity requires both financial investment and policy reforms. He said governments across the region have adopted long-term decarbonisation plans, with international institutions helping develop roadmaps to reduce reliance on fossil fuels.

Ozhan said renewable energy remains the primary pathway for lowering carbon emissions while meeting growing electricity demand. He added that modern energy systems require not only new power plants but also battery storage, stronger grid connections and supportive regulations to attract private investment.

Alongside renewable energy, Uzbekistan has begun developing its first nuclear power project. Construction started in June in the Jizzakh region, where the planned facility will feature two large reactors with capacities of about 1,000 megawatts each, along with two small modular reactors of around 55 megawatts.

World Nuclear Association Director General Sama Bilbao y León said the project reflects a broader trend among rapidly growing economies seeking dependable low-carbon electricity. She noted that about 75% of Uzbekistan’s electricity currently comes from natural gas and said nuclear power will help diversify the country’s energy mix while allowing greater use of natural gas in other sectors of the economy.

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Big Tech Giants Lose $2.3 Trillion in June as Investors Shift Beyond AI Leaders

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The world’s largest technology companies endured their weakest monthly performance in years during June, as investors pulled back from the artificial intelligence-driven rally that had dominated global markets and shifted their attention toward a broader range of companies.

The so-called “Magnificent Seven” — Nvidia, Apple, Microsoft, Alphabet, Amazon, Meta and Tesla — collectively lost about $2.3 trillion in market value during the month, marking a sharp reversal after leading Wall Street’s gains for more than three years.

Microsoft recorded one of the steepest declines, falling about 17 percent, its worst monthly performance since December 2000. Amazon dropped roughly 12 percent, Meta lost around 11 percent, while Nvidia and Alphabet declined by more than 5 percent each.

Apple reached a record closing price of $315.20 early in June before retreating more than 10 percent from its peak by month-end. Tesla experienced a volatile month, falling more than 6 percent during the first week before recovering most of those losses to finish the month nearly unchanged.

The decline comes as investors question whether the enormous spending on artificial intelligence infrastructure will generate sufficient returns. Major technology firms have committed hundreds of billions of dollars to expanding AI data centres and purchasing advanced semiconductors, driving up costs across the industry.

The world’s largest technology companies remain the biggest buyers of high-performance memory chips used in AI systems, contributing to supply shortages and soaring prices. Memory chip manufacturer Micron Technology recently reported earnings per share of $24.67 for its latest quarter, compared with $1.68 a year earlier, reflecting strong demand across the sector.

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Industry data also showed prices for DRAM memory chips, widely used in computers, smartphones and AI servers, surged by as much as 98 percent during the first quarter, increasing operating costs for companies investing heavily in artificial intelligence.

While the largest technology stocks struggled, much of the broader market continued to perform strongly. According to market analysts, companies outside the Magnificent Seven posted earnings growth of 17.5 percent during the first quarter, supported in part by semiconductor manufacturers and other technology suppliers benefiting from AI demand.

Analysts expect earnings growth among the remaining S&P 500 companies to exceed 20 percent in the second quarter, while forecasts for the Magnificent Seven have moderated. By the end of June, the S&P 493 Index, which excludes the seven technology giants, had gained 13.7 percent for the year, compared with a 6.6 percent decline for the Magnificent Seven. The broader S&P 500 Index advanced 7.4 percent over the same period.

Market observers say investors are becoming more selective, shifting their focus from AI infrastructure providers to companies expected to benefit from the technology’s wider adoption.

Despite the recent sell-off, the Magnificent Seven continue to deliver strong financial results, with estimated first-quarter earnings growth of about 29 percent. Analysts believe the group will remain influential in the technology sector, although investors are increasingly demanding clearer evidence that massive AI investments will translate into sustained profits.

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EBRD Approves $50 Million Loan to Support Young Entrepreneurs in Uzbekistan

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The European Bank for Reconstruction and Development (EBRD) has approved financing of up to $50 million for Uzbekistan’s O’zsanoatqurilishbank (SQB) to expand lending to young entrepreneurs, as many small businesses continue to face challenges in obtaining bank financing despite playing a major role in the country’s economy.

The funding is being provided under the EBRD’s Youth in Business programme for Central Asia and will support micro, small and medium-sized enterprises owned or led by entrepreneurs under the age of 35.

The initiative comes as Uzbekistan’s young population continues to grow. Official figures show the country had 9.63 million people aged between 14 and 30 at the beginning of 2025, representing 25.7% of the total population.

The loan is one of two EBRD operations in Uzbekistan’s financial sector worth up to $100 million. Alongside the SQB financing, the bank is providing an additional loan of up to $50 million to the Mortgage Refinancing Company of Uzbekistan to support the country’s residential mortgage market and promote more consistent lending practices.

Small businesses remain a key driver of Uzbekistan’s economy. According to the National Statistics Committee, they accounted for 51.5% of the country’s gross domestic product during the first nine months of 2025. More than 1.2 million small business entities were operating across the country as of October 1, 2025.

Despite strong economic activity, access to finance remains a significant obstacle for many entrepreneurs.

Francis Malige, Managing Director and Head of the Financial Institutions Business Group at the EBRD, said the issue is not a shortage of available capital but ensuring that financing reaches smaller businesses.

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“Liquidity is certainly abundant,” Malige said. “What we see is that a lot of it goes to sovereign lending, to state borrowing, but not necessarily to financing the real economy.”

He noted that many small businesses struggle to meet banks’ lending requirements because they often lack detailed financial records, formal business planning and sufficient operating history. According to Malige, banks assessing smaller firms must also consider the experience of founders, the quality of management and the strength of business plans rather than relying solely on traditional lending criteria.

Collateral remains another major challenge. Many young entrepreneurs and first-time business owners do not own property or other fixed assets that banks typically require as security for loans.

To address those barriers, the EBRD provides technical assistance, training and risk-sharing mechanisms that encourage financial institutions to lend to businesses with limited collateral.

The financing programme also aims to improve opportunities for women entrepreneurs. Ceren Güven Güres, Head of the UN Women Central Asia Liaison Office, said Uzbekistan has introduced important reforms supporting women’s economic participation, but many continue to face obstacles beyond access to credit.

She said awareness of available programmes, social expectations, gender stereotypes and family care responsibilities continue to affect women’s ability to establish and grow businesses. Güres added that entrepreneurs benefit not only from financing but also from mentoring, training and ongoing business support as their companies expand.

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