Connect with us

Health

Genetic Differences May Shape Effectiveness of Popular Weight-Loss Drugs, Study Finds

Published

on

Genetic variations may help explain why some patients respond better than others to widely used weight-loss medications, according to new research that points to the potential for more personalised treatment approaches.

Drugs such as Ozempic, Mounjaro and Zepbound have transformed the treatment of obesity in recent years. These medications belong to a class known as GLP-1 receptor agonists, which mimic a natural hormone that regulates appetite and blood sugar, helping people feel full for longer. Despite their growing use, patient outcomes vary widely, with some individuals losing less than 5 percent of their body weight while others achieve reductions exceeding 20 percent.

The study, conducted by researchers at the 23andMe Research Institute and published in Nature, examined genetic data alongside patient-reported experiences to better understand these differences.

Researchers analysed information from nearly 28,000 participants who had taken GLP-1 medications for a median period of just over eight months. Their findings identified specific genetic variants that appear to influence how individuals respond to these treatments.

One such variation in the GLP1R gene was linked to improved effectiveness. Individuals carrying a particular version of this gene lost an average of 0.76 kilograms more than those without it during the study period. Another variant in the GIPR gene was associated with an increased likelihood of side effects such as nausea and vomiting among patients taking tirzepatide-based drugs, though it did not affect weight loss outcomes.

Noura Abul-Husn, chief medical officer at the research institute, said current approaches to weight management often rely on trial and error. She noted that patients frequently begin treatment without clear expectations about how effective a drug will be or what side effects they might experience.

See also  Global Health Faces Funding, Workforce, and Climate Challenges in 2026

Experts not involved in the study said the findings offer useful insight but should be interpreted with caution. Marie Spreckley of the University of Cambridge said the genetic effects identified are relatively small in clinical terms, especially compared with the typical weight loss of 10 to 15 percent seen in trials of these medications. She added that factors such as dosage, treatment duration, sex and drug type likely play a larger role in determining outcomes.

Still, researchers believe the results could mark a step toward more tailored therapies. Cristóbal Morales, a specialist in metabolic health in Spain, said the ability to predict how patients will respond to treatment through pharmacogenomics could improve both drug selection and safety.

The findings highlight the growing interest in personalised medicine, where treatments are adapted to an individual’s genetic profile, though further studies are needed to confirm how these insights can be applied in clinical practice.

Health

Seven-Day Meditation Retreat Linked to Measurable Changes in Brain and Body, Study Finds

Published

on

A new study by researchers at the University of California San Diego suggests that a week of intensive meditation and mind-body practices may lead to measurable changes in both brain activity and physical health, highlighting a deeper connection between mental experience and biological function.

The findings, published in Communications Biology, indicate that consistent mental practices can activate biological pathways linked to brain flexibility, immune response, metabolism and natural pain relief. Researchers said the results point to a growing understanding that conscious experience and physical health are closely intertwined and may be used to improve overall well-being.

The study followed 20 healthy adults who participated in a seven-day residential retreat led by neuroscience educator Joe Dispenza. Participants completed about 33 hours of guided meditation along with lectures and group-based activities. Some elements were presented using an “open-label placebo” approach, meaning participants were aware that certain practices were described as placebos, yet previous research suggests such methods can still produce real effects through expectation and group dynamics.

To measure the impact of the retreat, researchers used functional MRI scans and blood tests before and after the programme. The results showed reduced activity in brain regions associated with constant internal thoughts, often described as mental “background noise,” suggesting more efficient brain function.

Blood samples also revealed changes linked to neuroplasticity, with lab-grown neurons exposed to post-retreat plasma showing increased growth and connectivity. Additional findings pointed to improved metabolic flexibility, as well as higher levels of endogenous opioids, the body’s natural painkillers.

Researchers also observed shifts in immune signalling, with both inflammatory and anti-inflammatory responses increasing in what they described as a more balanced and adaptive pattern. Participants reported stronger feelings of unity and altered awareness after the retreat, based on scores from a standard questionnaire used to assess such experiences.

See also  Eli Lilly’s Oral Pill Shows Strong Weight Loss Results in Clinical Trials

Hemal H. Patel, who was involved in the research, said the results go beyond simple stress reduction. He noted that combining multiple mind-body techniques appeared to influence several biological systems at once, with measurable effects in both brain scans and blood chemistry.

The study also found that patterns of brain connectivity observed after the retreat resembled those previously associated with psychedelic substances, suggesting that similar states may be achieved through meditation alone.

Despite the findings, researchers cautioned that the study was limited by its small sample size and lack of a control group. They said further research is needed to determine whether the same effects would be seen in larger and more diverse populations.

Alex Jinich-Diamant said the results provide rare biological evidence linking mental states to physical changes in the body. He added that the research offers new insight into how attention, belief and structured practices may leave measurable effects on human biology, opening potential pathways for improving health through non-pharmacological methods.

Continue Reading

Health

Uzbekistan to Launch Nationwide State Medical Insurance System in 2026

Published

on

Uzbekistan will begin introducing a nationwide state medical insurance system from 2026, part of a broader overhaul of the country’s healthcare financing and service delivery. The reform will introduce digital referrals, a national health insurance fund, and a guaranteed package of essential medical services funded through the state budget. Officials say the changes aim to improve efficiency, expand access, and reduce informal payments.

“State health insurance is a social protection system designed to guarantee access to quality healthcare services,” said Zokhid Ermatov, executive director of the State Health Insurance Fund.

Discussions about state medical insurance in Uzbekistan began in 2017, but implementing such a system required years of preparation. The State Health Insurance Fund was formally established in December 2020, and pilot programmes launched in the Syrdarya region in 2021 tested new financing mechanisms, regulatory frameworks, and digital health systems. In November 2025, the Cabinet of Ministers approved regulations governing how medical care funded through the state budget will be provided in public and private medical institutions, with the rules set to come into force on January 1, 2026.

At the centre of the new model is stronger primary healthcare. Patients will first visit their assigned family clinic, where doctors provide consultations, prescribe tests, and determine whether specialist care is needed. If necessary, patients will receive an electronic referral to hospitals or specialists. Emergency and urgent care will remain available without referrals.

The reform introduces a patient-centred financing model, where healthcare providers are paid by the State Health Insurance Fund based on services delivered. Primary healthcare will be funded through capitation payments, while hospital treatment will follow case-based payments, a structure designed to improve efficiency and treatment outcomes.

See also  India Dominates List of Most Polluted Cities as Global Air Quality Crisis Deepens

A fully digital referral system will allow patients to choose hospitals from a list of institutions contracted with the State Health Insurance Fund using a government portal or mobile app. Referrals will remain valid for 60 days, and waiting lists and hospitalisations will be managed through a unified electronic health information system.

The insurance system guarantees essential healthcare services, including family doctor consultations, diagnostic tests, outpatient treatment, preventive screening, some medicines, hospital care, and certain rehabilitation services. Patients will not be charged additional fees for services included in the approved package.

Funding for the program will come primarily from the state budget, ensuring citizens do not pay direct insurance contributions. Priority access will be given to socially vulnerable groups, including children with disabilities, orphans, pensioners, pregnant women, unemployed citizens, and low-income families. The State Health Insurance Fund will allocate resources across regions to strengthen medical services and reduce inequalities.

International organisations have praised Uzbekistan’s approach, noting that general tax financing and universal coverage can improve financial protection and ensure predictable healthcare funding. Jessika Yin, Health Policy Adviser at the World Health Organization in Uzbekistan, said the reforms align with global trends toward universal health coverage.

If implemented successfully, Uzbekistan’s state medical insurance system could represent a major step toward universal healthcare, ensuring that people receive care without facing financial hardship.

Continue Reading

Health

Study Links Agricultural Pesticide Exposure to Higher Cancer Risk in Peru

Published

on

Living in areas with high agricultural pesticide exposure is associated with higher cancer risks, according to a new study that highlights potential health impacts in vulnerable communities. Researchers found that widespread exposure to pesticides in food, water and the environment may increase the likelihood of developing certain cancers.

The study, published in Nature Health, analysed environmental data, cancer registries and biological samples across Peru. It found a strong association between pesticide exposure and cancer risk, marking one of the first large-scale efforts to connect environmental contamination with biological changes linked to the disease.

“This is the first time we have been able to link pesticide exposure, on a national scale, to biological changes suggesting an increased risk of cancer,” said Stéphane Bertani, a molecular biology researcher at the French National Research Institute for Sustainable Development.

The research was conducted in collaboration with several institutions, including the Institut Pasteur, the University of Toulouse and Peru’s National Institute of Neoplastic Diseases. Scientists mapped pesticide dispersion across the country over a six-year period from 2014 to 2019, identifying regions with the highest exposure levels.

The findings showed that people living in these high-risk zones were about 150% more likely to develop cancer. Areas of moderate to high exposure covered more than one-third of Peru’s territory, with contamination spreading up to 30 to 50 kilometres beyond agricultural land due to environmental factors such as wind and terrain.

The study examined data from more than 150,000 cancer patients diagnosed between 2007 and 2020. The highest exposure levels were found in the Andean highlands, where limited rainfall can intensify the accumulation of chemicals. Researchers noted that even pesticides not classified as carcinogenic by the World Health Organization may still contribute to harmful biological changes over time.

See also  French Senate Rejects Assisted Dying Bill, Sends It Back to Lower House

Laboratory analysis revealed that pesticide exposure can disrupt cellular processes that help maintain normal function. These disruptions may occur long before cancer develops, potentially increasing vulnerability to other risks such as infections or inflammation.

The study also found that certain cancers were more closely linked to pesticide exposure, particularly epithelial cancers affecting the digestive system, lungs and skin. In Peru, cases of liver cancer were found to overlap with regions of heavy pesticide use, raising questions about environmental factors contributing to the disease.

Researchers said the findings highlight the challenges of tracking pesticide exposure, given its widespread presence in ecosystems. They also warned that communities with limited healthcare access and intensive agricultural activity may face greater risks.

The study calls for stronger regulatory policies and improved monitoring to address environmental health risks. Experts say understanding how pesticide exposure affects human biology could play a key role in preventing cancer and protecting at-risk populations.

Continue Reading

Trending