Health
Global Rise in Early-Onset Cancer Linked to Obesity and Lifestyle Factors
A major international study has found that several forms of cancer are rising sharply among younger adults worldwide, with obesity and lifestyle changes emerging as key drivers behind the trend.
Published this week in the Annals of Internal Medicine, the study analysed cancer data from 42 countries across five continents between 2003 and 2017. It examined 13 cancer types previously reported to be increasing among younger people, confirming that several are indeed becoming more common in adults aged 20 to 49.
Thyroid, breast, colorectal, kidney, endometrial cancers and leukemia all showed consistent growth across most of the countries studied. Thyroid cancer recorded the steepest rise, with an average annual increase of 3.57%, followed by kidney cancer at 2.21% and endometrial cancer at 1.66%. Colorectal cancer, one of the most closely monitored malignancies among younger populations, rose by 1.45% annually on average. In nearly 70% of countries, new colorectal cancer diagnoses grew faster in younger adults than in older populations.
The researchers said the simultaneous rise across multiple cancer types points to shared risk factors. These may include the global surge in obesity, poor dietary habits, sedentary lifestyles, and widespread antibiotic use, all of which can affect gut health and metabolism.
However, experts emphasized that older adults still account for the majority of cancer diagnoses. While rates among younger adults are climbing, the overall burden remains concentrated in older populations. For instance, in the United States, around 50,000 women under 50 were diagnosed with breast cancer in 2022, compared to more than 210,000 cases in those over 50.
The study’s authors urged caution against focusing prevention efforts solely on early-onset cases, arguing instead for broader public health measures and more research into the underlying causes. “These findings can help guide future research and clinical priorities, including treatment strategies and support needs for younger cancer patients,” the report concluded.
A separate study published in JAMA Internal Medicine last month, however, questioned whether the apparent rise reflects a genuine increase in disease or improved detection. That research found that while diagnoses of several early-onset cancers—such as thyroid, kidney, colorectal, and pancreatic—have doubled since 1992, mortality rates have remained largely unchanged.
The findings suggest that better screening and overdiagnosis could explain part of the increase, rather than a true surge in life-threatening cancers. The authors warned that labeling early-onset cancers as an “epidemic” could lead to unnecessary testing and treatments, imposing emotional, physical, and financial strain on otherwise healthy young adults.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
Europe Records Sharp Rise in Sexually Transmitted Infections, ECDC Warns
Health
White House Rejects Report It Blocked Return of Ebola-Infected US Doctor
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