Health
Japanese Scientists Uncover Biological Evidence Behind Long COVID Brain Fog
In a groundbreaking discovery, scientists in Japan have identified what they describe as the first biological evidence explaining the cause of “brain fog” associated with Long COVID, shedding light on one of the most persistent and disabling aftereffects of the virus.
A research team from Yokohama City University, led by Professor Takuya Takahashi, found that people suffering from Long COVID show abnormally high activity of AMPA receptors — molecules in the brain essential for learning and memory. The findings, researchers say, indicate that Long COVID brain fog is not just a lingering symptom but a measurable molecular disorder.
“By applying our newly developed AMPA receptor PET imaging technology, we aim to provide a novel perspective and innovative solutions to the pressing medical challenge that is Long COVID,” said Professor Takahashi in a statement.
Brain fog — a broad term encompassing poor memory, slow thinking, and difficulty concentrating — is one of the most common symptoms reported by Long COVID patients. Studies estimate that more than 80 percent of people with the condition experience cognitive difficulties, often impairing their ability to work, study, or perform everyday tasks.
Until now, scientists have struggled to pinpoint a biological mechanism for the problem. While previous studies detected subtle structural changes in the brain, none had clearly linked them to specific molecular disruptions.
The Yokohama team focused on AMPA receptors (AMPARs), which act as key communication hubs between neurons. These receptors have been previously linked to mental health and neurological disorders such as depression, schizophrenia, and dementia. Using a newly developed technique known as K-2 AMPAR PET imaging, the researchers scanned the brains of 30 Long COVID patients and compared them with 80 healthy individuals.
The scans revealed that AMPAR density was significantly higher among those with Long COVID, and the greater the receptor activity, the more severe the cognitive symptoms reported by patients. The team also observed elevated levels of inflammation in affected individuals, suggesting that immune system overactivation in the brain may be driving the changes in receptor activity.
“Our findings clearly demonstrate that Long COVID brain fog should be recognized as a legitimate clinical condition,” said Takahashi. “This could encourage the healthcare industry to accelerate the development of diagnostic and therapeutic approaches for this disorder.”
According to the World Health Organization, around six in every 100 people who contract COVID-19 go on to develop post-COVID conditions. While the research remains in its early stages, experts say it opens the door to potential treatments aimed at reducing excessive AMPAR activity — a step that could one day help ease cognitive symptoms in millions of patients worldwide.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
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Health
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