Health
Mediterranean Diet Linked to Lower Dementia Risk, Study Finds
A long-term study has found that people who follow a Mediterranean-style diet are less likely to develop dementia and experience slower cognitive decline, even if they carry genetic risk factors for Alzheimer’s disease.
The research, published in Nature Medicine, highlights the role of diet in offsetting the risks associated with APOE4, a genetic variant known to increase the likelihood of Alzheimer’s. Individuals with one copy of the variant face a threefold risk, while those with two copies are up to 12 times more likely to develop the condition.
Despite these risks, the study shows that diet can make a significant difference. Researchers from a Harvard University hospital analyzed data spanning more than three decades from over 4,200 women and nearly 1,500 men. Participants’ dietary habits, blood samples, and genetic data were examined, with a smaller group also undergoing regular cognitive assessments.
The findings suggest that individuals who consistently ate a Mediterranean-style diet—rich in vegetables, fruits, nuts, whole grains, and low in red and processed meats—were less likely to develop dementia and showed slower rates of cognitive decline compared to those who did not.
“These findings suggest that dietary strategies, specifically the Mediterranean diet, could help reduce the risk of cognitive decline and stave off dementia by broadly influencing key metabolic pathways,” said Yuxi Liu, one of the study’s authors. “This recommendation applies broadly, but it may be even more important for individuals at a higher genetic risk, such as those carrying two copies of the APOE4 genetic variant.”
The research team noted that the APOE protein normally helps transport fats like cholesterol in the bloodstream and brain. The APOE4 variant appears to disrupt that process, affecting how the brain handles inflammation and the buildup of amyloid plaques—two factors strongly linked to Alzheimer’s disease. Still, carrying the variant does not mean someone will inevitably develop the illness.
About one-quarter of people have one copy of APOE4, while two to three percent carry two copies.
While the study strengthens the case for diet as a preventive tool, the researchers acknowledged limitations. The participants were mostly well-educated and of European ancestry, which means further studies in more diverse populations are needed to confirm the findings.
Even so, the authors said the results could change how doctors assess Alzheimer’s risks, suggesting that genetic and metabolite testing may become a greater part of future evaluations.
“In future research, we hope to explore whether targeting specific metabolites through diet or other interventions could provide a more personalised approach to reducing dementia risk,” Liu said.
The Mediterranean diet has previously been linked to improved cardiovascular health and longer lifespans. This latest study adds to growing evidence that it could also play a key role in protecting the brain from age-related decline.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
Europe Records Sharp Rise in Sexually Transmitted Infections, ECDC Warns
Health
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