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Study Links PFAS Exposure to Gut Microbiome Issues and Kidney Damage in Young Adults

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LOS ANGELES — New research suggests that exposure to per- and polyfluoroalkyl substances (PFAS), commonly referred to as “forever chemicals,” may contribute to disruptions in the gut microbiome that could, in turn, lead to kidney damage in young adults. This study adds to mounting concerns about the health impacts of these persistent chemicals.

PFAS, a group of synthetic chemicals, are widely used in a variety of everyday products, including food packaging, non-stick cookware, and water-resistant fabrics. Known as “forever chemicals” for their resilience, PFAS are nearly indestructible in nature and in the human body. As a result, they accumulate over time, becoming a near-universal presence in blood samples worldwide.

“Nearly everyone has PFAS in their blood, and these chemicals are linked to a range of negative health effects. But without interventions to remove PFAS from the body, there are no actionable recommendations to reduce exposure effects,” said Dr. Hailey Hampson, lead author and postdoctoral fellow at the Keck School of Medicine, in a statement.

Previous studies have associated PFAS exposure with a range of health issues, including liver damage, thyroid disorders, obesity, reproductive issues, and various cancers. This latest study highlights kidney disease as another potential consequence of exposure, focusing specifically on how changes in gut microbiome health may drive kidney damage in young adults.

In the study, researchers examined data from a cohort of 78 young adults, primarily Hispanic, aged 17 to 22, who are at higher risk of chronic kidney disease. Blood and stool samples collected from participants helped researchers measure PFAS levels, assess gut microbiome composition, and analyze metabolites circulating in their bodies. Four years later, the team reassessed the participants’ kidney function to evaluate long-term effects.

Findings revealed that participants with higher PFAS exposure experienced worse kidney function over time. The researchers linked this effect to changes in the gut microbiome, where PFAS exposure seemed to reduce anti-inflammatory metabolites and the bacteria responsible for producing them, while promoting inflammatory metabolites. The researchers found that these disruptions in gut health contributed to up to 50% of the decline in kidney function observed in the high-exposure group.

“These findings are an important piece of the puzzle about the many different health risks of PFAS,” said Dr. Jesse Goodrich, senior author of the study, which was published in Science of the Total Environment. “This information can help policymakers develop protections against exposure to these chemicals.”

While the sample size was limited, researchers emphasized the potential of their findings to guide future public health policies. As public awareness of PFAS contamination grows, the study offers early insights that may inform strategies to mitigate exposure and protect vulnerable populations.

The research team hopes that these insights will add to the growing body of evidence necessary for establishing regulations around PFAS, which remain ubiquitous in modern society despite their risks to human health.

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Papua New Guinea Launches Emergency Polio Response After New Cases Detected

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Health authorities in Papua New Guinea have launched an urgent national vaccination campaign following the detection of two polio cases in children, marking the country’s first confirmed outbreak of the virus since 2018.

The Ministry of Health confirmed this week that poliovirus was found in two otherwise healthy children during routine screenings. Subsequent testing of sewage samples in Lae, the country’s second-largest city, verified that the virus is circulating in the community.

Health Minister Elias Kapavore described the situation as “serious but manageable” and urged swift action. “We’ve dealt with this before and know what works,” he said in a public statement, referring to a previous outbreak in 2018 that resulted in 26 cases of paralysis.

Although Papua New Guinea was declared polio-free in 2000, the recent cases underscore the country’s vulnerability due to persistently low vaccination rates among children. Polio, a highly contagious viral disease, primarily affects children under five and can lead to irreversible paralysis or death in severe cases. The disease has been largely eradicated globally, with only a few endemic regions remaining, such as Afghanistan and Pakistan.

The United Nations Children’s Fund (UNICEF) is working closely with the government to support the emergency vaccination drive. “While the focus right now is on stopping this outbreak, we must take this opportunity to boost routine immunisation to 90 per cent and protect children long-term,” said Dr Veera Mendonca, UNICEF’s representative in Papua New Guinea.

Mendonca emphasised that a long-term strategy to raise routine immunisation coverage is essential to prevent future outbreaks. UNICEF is also assisting in disease surveillance and public education efforts to raise awareness of the risks posed by polio and the importance of vaccination.

The outbreak response will target communities across the country, with particular focus on areas with the lowest immunisation coverage. Health officials are urging parents to ensure their children receive the polio vaccine, which remains the only effective way to prevent infection.

With a population of nearly 12 million and significant logistical challenges in remote areas, ensuring high vaccination coverage will be a complex task. However, authorities remain confident in their ability to contain the outbreak with coordinated action and international support.

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Healthy Diet May Delay Onset of Menstruation, Study Finds

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A healthy diet may help delay the onset of menstruation in young girls, potentially reducing their risk of several health issues later in life, according to new research published in the journal Human Reproduction.

The study, conducted by researchers at the Fred Hutchinson Cancer Center in the U.S., followed over 7,500 girls between the ages of 9 and 14 to explore the link between dietary habits and the timing of their first menstrual periods. Girls who adhered to the healthiest diets were found to be 16% less likely to experience early menstruation compared to those with the poorest dietary habits.

In contrast, girls who consumed the most inflammatory foods — such as processed meats, sugary drinks, and refined carbohydrates — were 15% more likely to begin menstruating at an earlier age. These results were independent of body size, reinforcing the impact of diet quality regardless of a child’s weight or height.

These findings demonstrate the importance of a healthy diet regardless of body size,” said Dr. Holly Harris, lead author of the study and associate professor at Fred Hutchinson Cancer Center. “This is particularly relevant as early menstruation has been associated with long-term health risks including obesity, type 2 diabetes, cardiovascular disease, and breast cancer.”

Typically, girls begin puberty between the ages of 8 and 13, with menstruation occurring roughly two years after breast development. However, a trend toward earlier onset of puberty has raised concerns among health professionals, especially given its links to chronic illnesses in adulthood.

While the study highlights a possible role for diet in influencing menstrual timing, some experts have cautioned against drawing firm conclusions. Dr. Imogen Roger, a research fellow at Brighton and Sussex Medical School, noted that the data may reflect “reverse causation” — suggesting that the timing of puberty itself might influence dietary choices, rather than the reverse.

Diet was assessed close to the time of menarche for many of the girls,” Roger told Euronews Health. “We know that diet quality can decline during adolescence, so the association may not be entirely one-way.”

Nonetheless, researchers agree that ensuring children have access to nutritious foods — particularly during the crucial developmental window around puberty — is vital. Harris emphasized the importance of school meal programmes grounded in evidence-based nutrition.

This research reinforces the need for equitable access to healthy meals for all children and adolescents, especially through school-based initiatives,” she said.

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Europe Pays Less for Medicines Than the U.S., but Prices Still Vary Widely by Country

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As former U.S. President Donald Trump reignites debate over America’s high drug prices, attention is once again turning to how Europe manages to pay far less for the same medicines—even if pricing remains inconsistent across the continent.

Trump, speaking to journalists on Monday, criticized the European Union for what he called “brutal” and “nasty” tactics in negotiating with pharmaceutical companies. He announced a proposal to link U.S. drug prices to the lowest rates paid by other wealthy nations, declaring: “We’re going to pay what Europe pays.”

According to a RAND Corporation analysis, the U.S. spent $617.2 billion (€542.7 billion) on pharmaceuticals in 2022—nearly three times the €205.3 billion spent by 24 European countries combined.

While it’s true that Europeans generally pay less, the picture within the region is far from uniform. A report by the World Health Organization (WHO) found that drug prices vary widely across Europe, largely due to confidential negotiations with drugmakers, national budget constraints, and differing approaches to price regulation.

In Switzerland, per capita spending on medicines reached €525, whereas Croatia spent just €262. These discrepancies reflect not only national income levels but also the complex and opaque nature of price-setting in the region. “There’s essentially no transparency,” said Huseyin Naci, an associate professor of health policy at the London School of Economics.

Many European countries base their pricing on what other nations pay and use cost-effectiveness assessments to determine value. England and Sweden emphasize whether a drug justifies its cost, while Germany looks at how much additional benefit it offers over existing treatments.

Still, costs have risen across the continent. In Germany, for instance, hospital drug prices increased 11.5% from 2012 to 2022, while retail pharmacy prices rose 2.6% in the same period. Health insurers have warned that rising prices are putting pressure on public health budgets.

If U.S. policy changes or drug companies push European nations to raise their prices, it would be highly disruptive,” Naci said.

European nations also differ in how drug costs are shared between public systems and individuals. In Cyprus, 90% of medicine expenses were covered by government or mandatory schemes in 2022. In Bulgaria, that figure was only 23%. Meanwhile, patients in some countries still pay out-of-pocket or through co-payments, depending on the condition being treated.

Despite lower overall spending, experts caution that European healthcare systems are already stretched thin. “There’s not much room left to absorb higher pharmaceutical costs,” Naci said.

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