Health
WHO Warns of Rapidly Rising Antibiotic Resistance Threat Worldwide
A growing number of bacterial infections are no longer responding to standard antibiotic treatments, the World Health Organization (WHO) has warned in a new report that highlights an alarming surge in antimicrobial resistance (AMR) since 2018.
According to the findings, one in six bacterial infections globally is now resistant to conventional antibiotics. The WHO study, which analyzed data from more than 23 million cases across 104 countries in 2023, found that resistance has increased in about 40 percent of pathogen-antibiotic combinations over the past five years.
Antimicrobial resistance occurs when bacteria, viruses, and other pathogens evolve to survive exposure to drugs that once effectively killed them. This makes common infections such as those of the blood, gut, urinary tract, and sexually transmitted diseases harder—and sometimes impossible—to treat.
Health experts say human behavior contributes significantly to the problem. Patients who fail to complete prescribed antibiotic courses and doctors who misuse antibiotics for viral infections both accelerate resistance. “Antimicrobial resistance is outpacing advances in modern medicine, threatening the health of families worldwide,” said WHO Director-General Dr. Tedros Adhanom Ghebreyesus.
The problem is particularly severe in low- and middle-income countries, where diagnostic facilities and access to alternative treatments are limited. The report estimates that one in three bacterial infections in Southeast Asia and the Eastern Mediterranean are now resistant to antibiotics, compared to one in five in Africa. However, even high-income nations are not immune: a recent study predicted that deaths attributed to AMR in wealthier countries could rise from 125,000 in 2021 to nearly 192,000 annually by 2050.
The WHO report warns that resistance is rising fastest among Gram-negative bacteria—pathogens responsible for many severe hospital-acquired infections. These infections, which can lead to sepsis, organ failure, and death, are increasingly difficult to treat. In some regions of Africa, resistance rates for bacteria such as Klebsiella pneumoniae and E. coli have exceeded 70 percent, leaving few effective options for doctors.
Other bacteria, including Salmonella and Acinetobacter, are also showing growing resistance to key antibiotic classes such as carbapenems and fluoroquinolones. Of particular concern, the last reliable treatment for gonorrhoea—ceftriaxone—has begun to fail in parts of the Eastern Mediterranean, raising fears that the common sexually transmitted infection could soon become untreatable.
To combat the crisis, WHO has urged countries to reduce reliance on powerful “Watch” antibiotics and ensure that at least 70 percent of global antibiotic use comes from first-line “Access” drugs by 2030. “Our future depends on strengthening systems to prevent, diagnose, and treat infections while investing in next-generation antibiotics and rapid diagnostic tools,” Dr. Tedros emphasized.
Health
Medieval Manuscripts Reveal Thousands-Year History of Deadly Sheep Virus
DNA recovered from medieval manuscripts has given scientists new clues about the long history of sheep pox, a highly contagious disease that has threatened livestock for thousands of years.
An international team led by researchers at University College Dublin discovered traces of sheep pox virus in parchment used for some of Europe’s historic manuscripts. The findings suggest that animal diseases may have left genetic records in old documents, providing scientists with another way to study how pathogens developed over time.
During the Middle Ages, parchment was commonly made from the treated skin of sheep, goats and cattle. Researchers extracted DNA from the animal skins used to produce centuries-old manuscripts and identified genetic material linked to the sheep pox virus.
The study involved geneticists, historians, virologists, protein chemists and conservation specialists. Louis L’Hôte, the study’s lead author, said the research showed that parchment could preserve DNA from animal pathogens and provide valuable evidence about infectious diseases in the past.
Among the manuscripts examined was the approximately 1,000-year-old York Gospels, considered one of the finest surviving illuminated manuscripts from the late Anglo-Saxon period. Researchers also examined the Corpus Glossary at Corpus Christi College in Cambridge, an early English dictionary, along with other medieval texts from Britain and continental Europe.
In some manuscripts, several pages contained sheep pox virus DNA. Researchers said this could indicate that animals infected with the disease were used to produce the parchment.
The team compared the genetic material recovered from the manuscripts with older DNA samples obtained from Bronze Age sheep teeth. Their analysis indicated that sheep pox has affected livestock for more than 3,700 years.
Sheep pox spreads quickly among animals and can infect a large proportion of a flock. The disease causes fever and skin lesions and can result in death. Outbreaks can also cause major financial losses through reduced milk production, damage to wool and hides, and restrictions on livestock trade.
There is no evidence that sheep pox infects humans.
The research, published in Science Advances, also provided insight into how the virus changed over time. Scientists found that the sheep pox virus genome remained relatively stable during the past several thousand years.
L’Hôte said the finding contrasts with the evolutionary history of some other pathogens, including smallpox. The stability of the sheep pox genome may indicate that important genetic changes occurred much earlier in the virus’s history and helped it adapt to sheep.
Researchers said the work could encourage scientists to examine other archives and libraries for genetic traces of historic animal diseases. Ancient DNA preserved in manuscripts could offer a new source of information about outbreaks that affected livestock and societies long before modern disease surveillance existed.
Health
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Health
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