Health
Scientists Discover Drug That Makes Human Blood Lethal to Mosquitoes
Researchers have identified a promising new method to combat mosquito-borne diseases such as malaria by making human blood toxic to mosquitoes. Their study, published in Science Translational Medicine, suggests that a drug commonly used for rare diseases could help eliminate mosquitoes when ingested through a blood meal.
Nitisinone: A Potential Weapon Against Malaria
The study focused on nitisinone, a medication prescribed for individuals with rare inherited metabolic disorders that affect amino acid breakdown. The drug functions by blocking a specific enzyme, preventing harmful byproducts from accumulating in the human body.
When mosquitoes feed on blood containing nitisinone, the drug disrupts their digestion, ultimately leading to their death. This discovery could pave the way for a novel mosquito control strategy.
“One way to stop the spread of diseases transmitted by insects is to make the blood of animals and humans toxic to these blood-feeding insects,” said Lee R. Haines, associate research professor at the University of Notre Dame and co-lead author of the study.
The findings suggest that nitisinone could serve as an effective and complementary tool in the fight against malaria, which remains a major global health concern.
A Growing Need for Mosquito Control Solutions
Currently, personal protective measures such as bed nets, insect repellents, and window screens help reduce mosquito bites. Another approach involves the use of ivermectin, a drug that kills parasites and is sometimes used to target mosquitoes. However, repeated use of ivermectin can lead to drug resistance and environmental concerns.
Nitisinone, on the other hand, demonstrated significant advantages over ivermectin.
“Nitisinone performance was fantastic,” said Álvaro Acosta Serrano, professor of biological sciences at Notre Dame and co-corresponding author of the study. “It has a much longer half-life in human blood than ivermectin, meaning its mosquito-killing activity lasts much longer. This is critical when applied in the field for safety and economic reasons.”
Crucially, the drug proved effective in eliminating mosquitoes across all age groups, including older mosquitoes, which are the most likely to transmit malaria. It also showed effectiveness against insecticide-resistant mosquitoes.
A New Approach to Mosquito-Borne Disease Prevention
Haines suggested that in the future, alternating between nitisinone and ivermectin could enhance mosquito control efforts.
“For example, nitisinone could be used in areas where ivermectin resistance persists or where the drug is already heavily used for livestock and humans,” he said.
Mosquito-borne diseases, including malaria, dengue, West Nile virus, chikungunya, and yellow fever, continue to pose a growing health threat. The European Centre for Disease Prevention and Control (ECDC) has warned that climate change is creating more favorable conditions for invasive mosquito species in Europe, even though malaria was eradicated from the continent decades ago.
This new discovery offers a promising avenue for combating the spread of these diseases, potentially reducing the global burden of mosquito-borne infections.
Health
World Cup Emotion Can Strain the Heart, Cardiologists Warn Fans at Risk
As the World Cup begins, medical experts are cautioning football fans with underlying heart conditions that the emotional intensity of matches can place unexpected strain on the cardiovascular system.
Cardiologists say that the excitement, tension, and anxiety generated during high-stakes games can trigger physical reactions similar to intense exercise, raising heart rate, blood pressure, and stress hormones.
“Intense emotions, whether positive or negative, can act as ‘precipitating risk factors’ for cardiovascular events such as heart attack,” said Paola Santalucia, a cardiologist and board member of the European Heart Network.
She explained that moments of extreme excitement, such as a decisive penalty shootout or a last-minute goal, may pose risks for people already living with heart disease. Those with additional risk factors, including hypertension, obesity, or smoking habits, are also advised to be cautious during emotionally charged matches.
Research using wearable devices has shown that during major football events, some fans experience heart rates climbing as high as 150 beats per minute. That level is comparable to sprinting and reflects how strongly the body reacts to emotional stress.
A study examining supporters during the 2025 German Cup final found that even watching from home can significantly affect physiological responses. “They still had an increase in heart rate that compares to walking, even though they didn’t walk,” said Christian Deutscher, professor of sports economics at Bielefeld University and co-author of the study.
He noted that the most intense reactions often occur not during goals themselves, but during moments of uncertainty such as VAR checks, penalty shootouts, or shots striking the post. These unpredictable situations, he said, are what drive the strongest emotional and physical responses among fans.
Deutscher also pointed out that stadium spectators may experience even greater strain due to environmental factors such as heat and alcohol consumption.
However, experts emphasize that football itself is not inherently dangerous. Instead, it is the body’s natural response to excitement that can create temporary stress.
“The adrenergic stimulation is at its max: extreme high blood pressure, high heart rate, and adrenaline, cortisol, skyrocketing,” said Dan Atar, professor of cardiology at Oslo University Hospital. In rare cases, he added, this surge can contribute to the rupture of arterial plaque in vulnerable individuals, potentially leading to a heart attack.
Atar stressed that such events can occur in everyday situations as well, including physical exertion like shoveling snow. “It is in no way dangerous to watch a football game,” he said. “All this is physiologic. It’s not dangerous to be excited.”
Still, he acknowledged that combining emotional stress with alcohol, heat, and pre-existing conditions can increase risk for some viewers.
Doctors advise those at higher risk to continue prescribed medications, limit alcohol intake, avoid smoking, and watch for warning signs such as chest pain or irregular heartbeat.
“The key message is not to avoid enjoying the match, but to do so with moderation and awareness,” Santalucia said.
Health
AI Models Show Ability to Mimic Human Emotions, Offering New Pathways for Mental Health Research
Health
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