Health
Scientists Discover Drug That Makes Human Blood Lethal to Mosquitoes
Researchers have identified a promising new method to combat mosquito-borne diseases such as malaria by making human blood toxic to mosquitoes. Their study, published in Science Translational Medicine, suggests that a drug commonly used for rare diseases could help eliminate mosquitoes when ingested through a blood meal.
Nitisinone: A Potential Weapon Against Malaria
The study focused on nitisinone, a medication prescribed for individuals with rare inherited metabolic disorders that affect amino acid breakdown. The drug functions by blocking a specific enzyme, preventing harmful byproducts from accumulating in the human body.
When mosquitoes feed on blood containing nitisinone, the drug disrupts their digestion, ultimately leading to their death. This discovery could pave the way for a novel mosquito control strategy.
“One way to stop the spread of diseases transmitted by insects is to make the blood of animals and humans toxic to these blood-feeding insects,” said Lee R. Haines, associate research professor at the University of Notre Dame and co-lead author of the study.
The findings suggest that nitisinone could serve as an effective and complementary tool in the fight against malaria, which remains a major global health concern.
A Growing Need for Mosquito Control Solutions
Currently, personal protective measures such as bed nets, insect repellents, and window screens help reduce mosquito bites. Another approach involves the use of ivermectin, a drug that kills parasites and is sometimes used to target mosquitoes. However, repeated use of ivermectin can lead to drug resistance and environmental concerns.
Nitisinone, on the other hand, demonstrated significant advantages over ivermectin.
“Nitisinone performance was fantastic,” said Álvaro Acosta Serrano, professor of biological sciences at Notre Dame and co-corresponding author of the study. “It has a much longer half-life in human blood than ivermectin, meaning its mosquito-killing activity lasts much longer. This is critical when applied in the field for safety and economic reasons.”
Crucially, the drug proved effective in eliminating mosquitoes across all age groups, including older mosquitoes, which are the most likely to transmit malaria. It also showed effectiveness against insecticide-resistant mosquitoes.
A New Approach to Mosquito-Borne Disease Prevention
Haines suggested that in the future, alternating between nitisinone and ivermectin could enhance mosquito control efforts.
“For example, nitisinone could be used in areas where ivermectin resistance persists or where the drug is already heavily used for livestock and humans,” he said.
Mosquito-borne diseases, including malaria, dengue, West Nile virus, chikungunya, and yellow fever, continue to pose a growing health threat. The European Centre for Disease Prevention and Control (ECDC) has warned that climate change is creating more favorable conditions for invasive mosquito species in Europe, even though malaria was eradicated from the continent decades ago.
This new discovery offers a promising avenue for combating the spread of these diseases, potentially reducing the global burden of mosquito-borne infections.
Health
North African Dust Set to Worsen Air Quality Across Portugal
Health
New Zealand Approves MDMA Treatment for Severe PTSD Under Strict Medical Controls
Health
Irregular Sleep Patterns Linked to Higher Anxiety Risk Among Teenagers
Teenagers who regularly change their sleeping patterns between weekdays and weekends may face a greater risk of anxiety, according to a new study from researchers at the University of Southampton in the United Kingdom.
The findings come as students return to school after the summer break, when many adolescents may have become accustomed to later nights and longer mornings. The shift back to early school schedules can create a mismatch between weekday and weekend sleep patterns, a phenomenon researchers describe as “social jet lag.”
A review of 12 studies involving more than 230,000 participants found that teenagers experiencing greater levels of social jet lag were more likely to report higher levels of anxiety. The relationship also appeared to work in the opposite direction, with higher anxiety associated with greater disruption to sleep schedules.
However, researchers stressed that the findings show an association rather than proving that irregular sleep directly causes anxiety.
The study highlights the importance of encouraging healthy and consistent sleeping habits as part of efforts to support adolescent mental health. Anxiety is already one of the most common mental health problems among young people.
The World Health Organization estimates that anxiety disorders affect about 4.4% of children aged 10 to 14 and 5.5% of those aged 15 to 19 worldwide. Such disorders involve persistent fear or nervousness that can be difficult to control.
Researchers say adolescence is a particularly important period for sleep because biological changes naturally alter young people’s body clocks.
Sarah Chellappa, a co-author of the study from the University of Southampton, said teenagers generally experience a shift toward later sleep during puberty.
“During puberty, the body’s internal clock usually shifts back by a few hours,” she said, meaning teenagers naturally become sleepy later and may need to wake later as well.
Early school starts can conflict with this biological change. Social activities, online communication and other demands can also reduce the amount of sleep teenagers get during the week.
Hannah Ravenhall, lead author of the study, said the issue should not be viewed solely as a matter of individual responsibility.
She said broader social systems can influence young people’s sleep and called for greater recognition of the biological changes that occur during adolescence.
The researchers suggested that schools could consider whether their start times adequately reflect teenagers’ changing sleep needs. Parents could also review evening routines, including rules around screen use.
Rather than simply encouraging teenagers to go to bed earlier, the researchers argue that more consistent schedules and changes to the environments in which young people live and study could help support better sleep and mental wellbeing.
-
Entertainment2 years agoMeta Acquires Tilda Swinton VR Doc ‘Impulse: Playing With Reality’
-
Sports2 years agoChina’s Historic Olympic Victory Sparks National Pride Amid Controversy
-
Business2 years agoSaudi Arabia’s Model for Sustainable Aviation Practices
-
Business2 years agoRecent Developments in Small Business Taxes
-
Home Improvement2 years agoEffective Drain Cleaning: A Key to a Healthy Plumbing System
-
Politics2 years agoWho was Ebrahim Raisi and his status in Iranian Politics?
-
Sports2 years agoKeely Hodgkinson Wins Britain’s First Athletics Gold at Paris Olympics in 800m
-
Business2 years agoCarrectly: Revolutionizing Car Care in Chicago
