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Study Finds Calorie Restriction Can Boost Chemotherapy Effectiveness in Sarcoma Treatment

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A new Portuguese-Brazilian study suggests that controlling calorie intake can improve the effectiveness of chemotherapy in treating sarcomas, a rare type of cancer, while also protecting healthy cells from treatment damage. The research, conducted by the RISE Health Research Unit in collaboration with the Federal University of Piauí in Brazil, was released on World Cancer Day, February 4, a day promoted by the International Union Against Cancer (UICC) to raise awareness of cancer prevention, early diagnosis, and access to treatments.

The study found that moderate calorie restriction, alone or in combination with chemotherapy drugs such as doxorubicin, significantly reduced tumour size and weight, increased tumour inhibition rates, and protected normal cells from chemotherapy-induced damage. Researchers reported that a 40 percent reduction in calorie intake induced metabolic stress in the tumour microenvironment, disrupting processes essential for cancer growth.

“From this experimental study, carried out on animal models, we observed that calorie restriction for short periods can be favourable to cancer treatment,” said Moisés Tolentino Bento da Silva of RISE Health, who led the research in Portugal. He explained that higher energy intake fuels cancer progression, so reducing calorie intake limits the energy supply to the tumour and enhances chemotherapy effectiveness.

The study also highlighted additional benefits of calorie restriction. It supports DNA repair in healthy tissues damaged by chemotherapy and reprogrammes lipid metabolism, lowering cholesterol and triglyceride levels that feed malignant cells. Researchers noted that these effects may also have broader implications for managing chronic conditions such as type II diabetes, cardiovascular disease, and neurodegenerative disorders.

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Alongside dietary control, the study emphasized the importance of regular physical exercise during cancer treatment. “If cancer patients exercise adequately and regularly during chemotherapy, they will experience fewer side effects in various systems, such as the gastrointestinal tract,” Tolentino Bento da Silva said. “Physical exercise, together with a good diet, has great benefits for the patient’s quality of life, whether it is preventative, during treatment, or after oncological therapy.”

The research, published in the journal Cancers, provides new evidence that lifestyle interventions, including calorie management and physical activity, can complement traditional cancer therapies. While the study was conducted on animal models, the findings open pathways for clinical research and potential integration into patient care protocols.

As cancer treatment continues to evolve, experts suggest that non-pharmacological approaches such as diet and exercise may play an increasingly important role in supporting patients, improving treatment outcomes, and enhancing overall well-being during chemotherapy.

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Good Sleep May Matter More Than Diet or Exercise for Teenagers’ School Performance

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Good sleep may have a stronger influence on teenagers’ academic performance and social lives than diet, exercise or screen time, according to new research examining the daily factors that shape young people’s well-being.

The findings suggest that sleep could be particularly important for children experiencing symptoms of depression, anxiety or psychotic-like experiences, which have been linked to difficulties at school and in relationships.

Researchers examined data from more than 6,000 children for academic performance and more than 7,000 for social difficulties. The participants were aged between 10 and 13 and were assessed on four lifestyle factors: sleep quality, screen use, physical activity and diet.

Children showing symptoms of mental health difficulties generally performed worse academically and experienced more social problems. However, researchers found that lifestyle habits appeared to explain a significant part of this relationship, with sleep standing out as the most important factor.

“We expected sleep to be important, but we didn’t expect it to stand out so clearly above other lifestyle factors, particularly screen time,” said Jason Smucny, the study’s lead author at the University of California, Davis.

Researchers said poor sleep can cause daytime tiredness, problems with concentration and weaker executive functioning, all of which can make it harder for students to learn, complete schoolwork and perform well in examinations.

Sleep may also affect relationships. Disrupted or inadequate sleep can contribute to irritability and social withdrawal, potentially making it harder for young people to communicate with friends and maintain healthy relationships.

The researchers said their findings point to sleep quality as an important pathway through which early mental health symptoms can affect everyday functioning.

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Tara Niendam, the study’s senior author, said parents, teachers and health professionals often concentrate on symptoms such as anxiety and depression, but families are also concerned about how those difficulties affect school performance, friendships and daily activities.

The research suggests that improving sleep routines could be one practical way of supporting young people facing these challenges.

Adolescents have increasingly struggled to get enough sleep, with previous research indicating that teenage sleep levels have declined over recent decades. School demands, social activities, technology use and changing schedules can all interfere with regular sleeping patterns.

The researchers stressed that better sleep cannot address every mental health problem. However, establishing consistent sleep routines may support emotional health and help young people manage the demands of school and social life.

With summer giving students an opportunity to recover from demanding school schedules, the findings highlight the potential importance of using the break to establish healthier and more consistent sleeping habits before the new academic year begins.

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Study Suggests GLP-1 Weight-Loss Drugs May Lower Fracture Risk in People With Type 2 Diabetes

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A large US study has found that GLP-1 medicines, including widely prescribed treatments such as Ozempic, may reduce the risk of serious bone fractures in people with type 2 diabetes, challenging concerns that rapid weight loss associated with the drugs could weaken bones.

Researchers reported that patients treated with GLP-1 medicines had a 21% lower risk of fragility fractures over a three-year period compared with similar patients who received DPP-4 medicines, another class of drugs commonly used to manage type 2 diabetes.

The findings are based on an analysis of health records from more than 133,000 adults aged between 50 and 90 in the United States who were treated for type 2 diabetes between 2015 and 2022.

People living with type 2 diabetes face a greater risk of fractures caused by low-energy incidents, such as falls from standing height, even though they often have normal or higher-than-average bone density. Researchers said this may be linked to reduced bone strength, changes in bone structure and faster bone loss rather than bone density alone.

The study found the greatest reductions in vertebral fractures, which declined by 32%, while hip and femur fractures fell by 30% among patients taking GLP-1 medicines.

Researchers also noted that the lower fracture risk appeared to be independent of changes in body weight or blood sugar control. This raises the possibility that the medicines may have a direct effect on bone health rather than reducing fractures simply through weight loss or improved diabetes management.

The results challenge long-standing concerns that rapid weight loss could increase fracture risk by reducing bone density. Those concerns have accompanied the growing use of GLP-1 medicines, which have become increasingly popular for treating both type 2 diabetes and obesity.

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Despite the encouraging findings, the researchers stressed that the study does not establish a direct cause-and-effect relationship. Because the research was based on observational health records rather than a randomized clinical trial, other factors may have influenced the results. Differences in physical activity, muscle strength, nutrition and existing bone health could all have contributed to the lower fracture rates.

The study also found no evidence that GLP-1 medicines reduced fracture risk among people who were taking the drugs without having type 2 diabetes. That suggests the apparent benefit may be specific to patients with diabetes and may not extend to those using the medicines solely for weight management.

The authors said additional prospective clinical trials are needed to confirm whether GLP-1 medicines provide direct protection against fractures and to determine whether any benefits continue during longer periods of treatment.

The findings add to growing research into the wider health effects of GLP-1 medicines as their use continues to expand around the world for diabetes care and weight management.

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Greece Reports Rising West Nile Virus Cases as Europe Faces Active Summer Outbreak

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Greece is experiencing a sharp rise in West Nile virus infections, with health authorities warning that the mosquito-borne disease is spreading more widely than confirmed case numbers suggest. The country, alongside Italy, has recorded the highest level of virus activity in Europe this season.

Greece’s National Public Health Organisation reported 23 new infections during the past week. Since the start of the transmission season in spring through August 5, the country has confirmed 65 cases. Of those, 54 patients developed severe neurological complications, including encephalitis, meningitis or acute flaccid paralysis, while 11 experienced mild symptoms or no significant effects on the central nervous system.

The outbreak has resulted in six deaths, all involving patients over the age of 65 who suffered severe neurological illness.

Health officials cautioned that the confirmed figures represent only a fraction of the virus’s actual spread. Based on seroepidemiological data, authorities estimate that for every patient diagnosed with serious neurological disease, about 140 other people may have been infected without being diagnosed because they developed mild symptoms or none at all.

The virus continues to circulate across several regions of Greece. Cases have been identified in 25 municipalities covering Attica, Thessaly and Central Macedonia. The highest concentration has been recorded in Attica, where public health officials say transmission has been particularly intense this summer.

Of the 65 confirmed patients, 20 remain in hospital. Twelve are receiving treatment in general wards, while eight are in intensive care units. Thirty-eight patients have been discharged, and one person did not require hospital treatment.

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The outbreak is part of a broader rise in West Nile virus activity across Europe. According to the European Centre for Disease Prevention and Control (ECDC), human infections have also been confirmed in Italy, Romania, France, North Macedonia, Spain and Germany through July 29.

The ECDC has identified 49 affected areas across seven European countries. Italy accounts for the largest number, with 30 affected areas, followed by Greece with eight. Romania has four affected areas, while France, North Macedonia and Spain each have two, and Germany has one.

Italy has also reported the highest number of confirmed human infections in Europe this season, with 94 cases. North Macedonia and Spain have each recorded seven cases, Romania has reported five, France two and Germany one.

West Nile virus is transmitted primarily through the bites of infected mosquitoes. Most infected people experience either mild flu-like symptoms or no symptoms at all. In a small proportion of cases, particularly among older adults and people with underlying health conditions, the infection can lead to serious neurological disease.

Public health authorities are urging residents and visitors to reduce mosquito exposure by using insect repellent, wearing protective clothing and eliminating standing water where mosquitoes breed as surveillance and prevention efforts continue throughout the summer.

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