Health
Study Links High BMI to Increased Risk of Vascular Dementia
Being overweight significantly raises the likelihood of developing vascular dementia, a progressive brain disease caused by reduced blood flow to the brain, according to a large study conducted by researchers in the United Kingdom and Denmark. The condition is the second most common form of dementia after Alzheimer’s disease, the Alzheimer’s Society in the UK reports, and leads to nerve cell damage, memory loss, and cognitive decline.
Obesity has long been associated with higher dementia risk, but until now, it was unclear whether excess weight directly contributes to the disease or merely reflects other underlying health conditions. Researchers analysed data from more than 500,000 participants across the two countries and found a clear causal link between higher body mass index (BMI) and vascular dementia.
The team employed a method called Mendelian randomisation, which compares individuals born with genes that predispose them to higher BMI with those who are not. Their findings showed that people with a genetically higher BMI had a substantially increased risk of vascular-related dementia. High blood pressure was identified as a major factor explaining much of this risk.
“This study shows that high body weight and high blood pressure are not just warning signs, but direct causes of dementia,” said Ruth Frikke-Schmidt, the study’s lead author and professor at the University of Copenhagen, who also serves as chief physician at Copenhagen University Hospital. She noted that maintaining a healthy weight and controlling blood pressure could be important steps in reducing the risk of dementia later in life.
Frikke-Schmidt added that while recent studies of weight-loss medications have not shown a benefit in halting cognitive decline in early Alzheimer’s, it remains to be tested whether early interventions—before the onset of cognitive symptoms—could protect against vascular dementia. “Our present data would suggest that early weight-loss interventions would prevent dementia, and especially vascular-related dementia,” she said.
Globally, dementia remains a major public health challenge, with nearly 10 million new cases reported each year, according to the World Health Organization. People living with dementia experience severe declines in memory, thinking, reasoning, and daily functioning, placing significant burdens on patients, families, and healthcare systems.
The study highlights the importance of early prevention, particularly through weight management and blood pressure control. As evidence grows linking lifestyle factors to dementia risk, experts say interventions targeting obesity and hypertension could provide a critical opportunity to reduce the future global burden of vascular dementia.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
Europe Records Sharp Rise in Sexually Transmitted Infections, ECDC Warns
Health
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