Health
French Scientists Use Light Therapy to Restore Brain Function in Parkinson’s Patients
French researchers have reported promising early results from a groundbreaking clinical trial that uses light to stimulate damaged nerve cells in the brains of Parkinson’s disease patients. The experimental technique has shown potential to slow neurological decline and partially restore brain function, according to scientists at Grenoble University Hospital.
The clinical trial, still in its early stages, has been conducted on seven patients diagnosed with early-stage Parkinson’s. In three of those cases, researchers observed a notable slowdown in the progression of symptoms and signs of restored brain function following continued light-based stimulation.
Speaking to Radio France, Dr. Stephan Chabardès, a neurosurgeon leading the project, explained that the approach targets dopamine-producing neurons—cells that are progressively destroyed as Parkinson’s advances. “Our aim is to slow down the degeneration of these neurons, which are critical for motor function,” he said.
Parkinson’s disease currently affects an estimated 10 million people globally, a figure projected to double by 2050, according to Parkinson’s Europe. The disease is marked by symptoms such as tremors, muscle stiffness, and reduced mobility, all of which result from a steady loss of dopamine receptors. By the time these symptoms become evident, roughly half of the affected neurons may already be damaged.
The technique developed by Chabardès and his team uses beams of light to stimulate the mitochondria—the energy-producing structures inside cells—within dopamine neurons. By energising these mitochondria, the researchers hope to revive and sustain the function of compromised nerve cells.
To reach the affected areas deep within the brain, the team engineered a miniaturised device that combines cutting-edge electronics, nanotechnology, and photonics. “It is the synergy between neurosurgical expertise and innovation in micro- and nanotechnologies that allows us to achieve these feats,” Chabardès said.
The compact system delivers the light directly to the targeted brain regions without invasive surgery, offering a potentially safer and more sustainable treatment than traditional methods such as deep brain stimulation or medication.
Although the results so far are limited, Chabardès remains cautiously optimistic. “It’s very preliminary, but what we are seeing is quite promising,” he said. A larger clinical trial will only proceed if these early findings are confirmed as stable and reproducible over time.
If further validated, the approach could mark a significant step toward more effective, non-invasive treatments for Parkinson’s—a disease that currently has no cure.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
Europe Records Sharp Rise in Sexually Transmitted Infections, ECDC Warns
Health
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