Health
UK Study Finds Common Chemicals May Harm Gut Bacteria and Human Health
Dozens of widely used chemicals could be toxic to gut bacteria, potentially affecting human health, according to a new study by UK scientists. Researchers tested more than 1,000 chemicals in the laboratory and identified 168 that appeared to prevent healthy gut bacteria from growing, raising concerns about their impact on the gut microbiome.
The gut microbiome consists of thousands of bacterial species and other microorganisms that live in the digestive tract. Scientists have linked it to numerous health outcomes, including cancer, heart disease, type 2 diabetes, insomnia, and complications during pregnancy such as preterm birth.
In the study, researchers tested 1,076 chemical contaminants—including pesticides, herbicides, industrial chemicals, and so-called “forever chemicals” like per- and polyfluoroalkyl substances (PFAS)—on 22 species of gut bacteria. Many of the harmful chemicals, including flame retardants and plasticisers used in everyday products, were not previously known to affect living organisms, the team said.
“We were surprised that some of these chemicals had such strong effects,” said Indra Roux, a researcher at the University of Cambridge and one of the study’s authors. “Many industrial chemicals that we are regularly in contact with weren’t thought to affect living organisms at all, but they do.”
The chemicals can enter the human body through food, water, and other environmental exposures. While the precise level of real-world exposure remains unclear, the researchers noted that environmental pollutants have been linked to changes in the gut microbiome that may contribute to obesity and insulin resistance.
Laboratory tests also revealed that some bacteria altered their functions to survive chemical exposure, which in some cases led to increased resistance to antibiotics. If similar effects occur in humans, this could make infections harder to treat and worsen the growing public health problem of antimicrobial resistance (AMR).
Traditionally, chemical safety assessments focus on the chemicals’ intended targets—such as how effectively a pesticide kills pests—without considering their potential impact on the human gut. “Safety assessments of new chemicals for human use must ensure they are also safe for our gut bacteria, which could be exposed to the chemicals through our food and water,” said Stephan Kamrad, another author from the University of Cambridge.
The study, published in Nature Microbiology, calls for more real-world data to determine whether laboratory findings translate to effects on human gut health. Meanwhile, researchers advise people to reduce exposure where possible, for example by washing fruits and vegetables thoroughly and avoiding the use of pesticides at home.
The findings add to growing evidence that everyday chemical exposures may have unintended consequences on human health, highlighting the need for more comprehensive safety testing that considers the gut microbiome.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
Europe Records Sharp Rise in Sexually Transmitted Infections, ECDC Warns
Health
White House Rejects Report It Blocked Return of Ebola-Infected US Doctor
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