Health
Experts Call for Overhaul in Obesity Diagnosis Amid Criticism of BMI Reliance
Global health experts have called for a fundamental reevaluation of how obesity is diagnosed, urging a shift from the long-standing reliance on body mass index (BMI) to a more nuanced and individualized approach. The recommendations come from a panel of 56 specialists and patients, who published their findings in The Lancet Diabetes & Endocrinology.
A Complex Condition
Obesity, affecting roughly one in eight people worldwide, is a risk factor for numerous health conditions, including type 2 diabetes, cardiovascular disease, and certain cancers. However, experts argue that it is not always synonymous with ill health. The commission has proposed distinguishing between clinical obesity, a chronic disease marked by organ dysfunction or physical limitations caused by excess fat, and preclinical obesity, where individuals have obesity but maintain normal organ function.
“There are some people who have obesity and manage to live a relatively normal life … and on the other hand, you have [people] who may suffer significant health issues due to obesity alone,” said Dr. Francesco Rubino, the commission’s chair and a professor at King’s College London.
BMI Under Fire
BMI, a measure derived from a person’s weight and height, has been the primary diagnostic tool for obesity since the World Health Organization adopted it in the 1990s. A BMI of 30 or higher classifies an adult as obese. While BMI offers a simple proxy for body fat and related health risks, critics say it is flawed and outdated.
“It’s not just how much fat you have, it’s also where the fat is that’s important,” said Dr. Adam Collins, a nutrition expert at the University of Surrey. He highlighted that BMI does not account for fat distribution or differentiate between fat and muscle mass, leading to potential misclassifications.
Athletes with high muscle mass, for example, may fall into the obese category despite being in excellent health.
A New Framework
The commission has recommended that BMI remain a preliminary screening tool but that an official diagnosis of clinical obesity should involve more comprehensive criteria. These include signs such as obesity-induced breathlessness, heart failure, and joint pain, among others.
Adopting this approach could reduce overdiagnosis and ensure medical care is tailored to an individual’s health needs rather than focusing solely on weight loss. This shift is especially crucial as governments debate how to allocate resources, such as expensive weight-loss drugs like Wegovy and Mounjaro, which are in limited supply.
Changing Perspectives
Beyond medical practice, experts hope the new framework will combat the stigma around obesity and promote better understanding of metabolic health for people of all sizes. “This leads to a change in practice and, maybe even before that, a change in mindsets,” Rubino said.
Though it may take time to implement these changes, advocates believe this step could reshape how obesity is perceived and treated globally.
Health
Medieval Manuscripts Reveal Thousands-Year History of Deadly Sheep Virus
DNA recovered from medieval manuscripts has given scientists new clues about the long history of sheep pox, a highly contagious disease that has threatened livestock for thousands of years.
An international team led by researchers at University College Dublin discovered traces of sheep pox virus in parchment used for some of Europe’s historic manuscripts. The findings suggest that animal diseases may have left genetic records in old documents, providing scientists with another way to study how pathogens developed over time.
During the Middle Ages, parchment was commonly made from the treated skin of sheep, goats and cattle. Researchers extracted DNA from the animal skins used to produce centuries-old manuscripts and identified genetic material linked to the sheep pox virus.
The study involved geneticists, historians, virologists, protein chemists and conservation specialists. Louis L’Hôte, the study’s lead author, said the research showed that parchment could preserve DNA from animal pathogens and provide valuable evidence about infectious diseases in the past.
Among the manuscripts examined was the approximately 1,000-year-old York Gospels, considered one of the finest surviving illuminated manuscripts from the late Anglo-Saxon period. Researchers also examined the Corpus Glossary at Corpus Christi College in Cambridge, an early English dictionary, along with other medieval texts from Britain and continental Europe.
In some manuscripts, several pages contained sheep pox virus DNA. Researchers said this could indicate that animals infected with the disease were used to produce the parchment.
The team compared the genetic material recovered from the manuscripts with older DNA samples obtained from Bronze Age sheep teeth. Their analysis indicated that sheep pox has affected livestock for more than 3,700 years.
Sheep pox spreads quickly among animals and can infect a large proportion of a flock. The disease causes fever and skin lesions and can result in death. Outbreaks can also cause major financial losses through reduced milk production, damage to wool and hides, and restrictions on livestock trade.
There is no evidence that sheep pox infects humans.
The research, published in Science Advances, also provided insight into how the virus changed over time. Scientists found that the sheep pox virus genome remained relatively stable during the past several thousand years.
L’Hôte said the finding contrasts with the evolutionary history of some other pathogens, including smallpox. The stability of the sheep pox genome may indicate that important genetic changes occurred much earlier in the virus’s history and helped it adapt to sheep.
Researchers said the work could encourage scientists to examine other archives and libraries for genetic traces of historic animal diseases. Ancient DNA preserved in manuscripts could offer a new source of information about outbreaks that affected livestock and societies long before modern disease surveillance existed.
Health
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Health
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