Health
Early Introduction of Peanuts Linked to Sharp Decline in Childhood Allergies, Study Finds
A major shift in medical advice on introducing food allergens to infants appears to be paying off, with new research showing a significant drop in peanut allergies among American children.
According to a study published in the journal Pediatrics, roughly 60,000 children in the United States have avoided developing peanut allergies since 2015, when medical guidelines began recommending that babies be introduced to peanut-containing foods as early as four months of age. The new approach, which aligned U.S. policy with European standards, reversed decades of previous advice that urged parents to delay introducing such foods.
Dr. David Hill, an allergist and researcher at the Children’s Hospital of Philadelphia, said the findings mark a major success in allergy prevention. “I can actually come to you today and say there are fewer kids with food allergy today than there would have been if we hadn’t implemented this public health effort,” Hill said.
The research team examined health data from dozens of pediatric practices across the country, tracking food allergy diagnoses before and after the introduction of the new guidelines. They found that peanut allergies in children up to age three dropped by more than 27 percent after the 2015 recommendations for high-risk infants and by over 40 percent after the guidelines were expanded in 2017 to include all children.
Peanut allergy occurs when the immune system mistakenly identifies peanut proteins as harmful, triggering symptoms that can include hives, respiratory distress, and even life-threatening anaphylaxis. For years, experts believed delaying exposure could help prevent these reactions. However, the landmark 2015 LEAP (Learning Early About Peanut Allergy) trial led by Professor Gideon Lack at King’s College London overturned that view. The study found that introducing peanut products to infants dramatically reduced the risk of developing peanut allergies by more than 80 percent, with protection lasting well into adolescence.
Despite the evidence, adoption of the new guidance was initially slow. Some parents and health professionals were uncertain about how to safely introduce allergens outside clinical trials. Hill noted that updated recommendations issued in 2021 clarified the process, encouraging parents to introduce peanuts and other allergenic foods between four and six months without the need for prior testing.
“It doesn’t have to be a lot of food,” Hill said. “Small tastes of peanut butter, milk-based yoghurt, soy-based yoghurts, or tree nut butters are simple, safe ways to expose the immune system early on.”
The findings offer a hopeful sign that early exposure to allergens could help reduce food allergies on a population level—transforming what was once a life-threatening childhood condition into a largely preventable one.
Health
Medieval Manuscripts Reveal Thousands-Year History of Deadly Sheep Virus
DNA recovered from medieval manuscripts has given scientists new clues about the long history of sheep pox, a highly contagious disease that has threatened livestock for thousands of years.
An international team led by researchers at University College Dublin discovered traces of sheep pox virus in parchment used for some of Europe’s historic manuscripts. The findings suggest that animal diseases may have left genetic records in old documents, providing scientists with another way to study how pathogens developed over time.
During the Middle Ages, parchment was commonly made from the treated skin of sheep, goats and cattle. Researchers extracted DNA from the animal skins used to produce centuries-old manuscripts and identified genetic material linked to the sheep pox virus.
The study involved geneticists, historians, virologists, protein chemists and conservation specialists. Louis L’Hôte, the study’s lead author, said the research showed that parchment could preserve DNA from animal pathogens and provide valuable evidence about infectious diseases in the past.
Among the manuscripts examined was the approximately 1,000-year-old York Gospels, considered one of the finest surviving illuminated manuscripts from the late Anglo-Saxon period. Researchers also examined the Corpus Glossary at Corpus Christi College in Cambridge, an early English dictionary, along with other medieval texts from Britain and continental Europe.
In some manuscripts, several pages contained sheep pox virus DNA. Researchers said this could indicate that animals infected with the disease were used to produce the parchment.
The team compared the genetic material recovered from the manuscripts with older DNA samples obtained from Bronze Age sheep teeth. Their analysis indicated that sheep pox has affected livestock for more than 3,700 years.
Sheep pox spreads quickly among animals and can infect a large proportion of a flock. The disease causes fever and skin lesions and can result in death. Outbreaks can also cause major financial losses through reduced milk production, damage to wool and hides, and restrictions on livestock trade.
There is no evidence that sheep pox infects humans.
The research, published in Science Advances, also provided insight into how the virus changed over time. Scientists found that the sheep pox virus genome remained relatively stable during the past several thousand years.
L’Hôte said the finding contrasts with the evolutionary history of some other pathogens, including smallpox. The stability of the sheep pox genome may indicate that important genetic changes occurred much earlier in the virus’s history and helped it adapt to sheep.
Researchers said the work could encourage scientists to examine other archives and libraries for genetic traces of historic animal diseases. Ancient DNA preserved in manuscripts could offer a new source of information about outbreaks that affected livestock and societies long before modern disease surveillance existed.
Health
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Health
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