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Novo Nordisk Reports Promising Trial Results for Next-Gen Obesity Drug, Shares Surge

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Novo Nordisk, Europe’s largest pharmaceutical company, announced encouraging trial results for its next-generation obesity drug, amycretin, propelling its shares to a 7.13% gain in Copenhagen on Friday.

Key Trial Findings

The trial revealed that patients on the highest dose of 20 milligrams of amycretin achieved an estimated weight loss of 22% over 36 weeks. This result closely rivals Eli Lilly’s obesity drug Zepbound, which achieved a 22.5% weight loss over 72 weeks, and Lilly’s next-generation treatment, retatrutide, which reported a 24.4% weight reduction over 48 weeks.

Novo Nordisk’s amycretin is seen as a major contender in the competitive weight-loss drug market, particularly as the patent for its blockbuster treatment Wegovy is set to expire in the early 2030s.

Advancements in Treatment

Amycretin represents a significant step forward in weight-loss therapies, combining the effects of two hormones, glucagon-like peptide-1 (GLP-1) and amylin. This dual action enhances satiety and regulates blood sugar levels, providing a more comprehensive approach compared to Wegovy, which focuses solely on GLP-1.

The trials tested once-weekly injections of amycretin in 125 participants, showing:

  • 9.7% weight loss with a 1.25-milligram dose over 20 weeks.
  • 16.2% weight loss with 5 milligrams over 28 weeks.
  • 22.1% weight loss with 20 milligrams over 36 weeks.

Most side effects were gastrointestinal and mild to moderate in severity. Novo Nordisk plans to advance amycretin into further clinical trials for adults with obesity or overweight conditions.

Market Impact and Competition

Following the announcement, Novo Nordisk’s shares saw a significant surge, recovering from a 14% decline over the past year. Meanwhile, Eli Lilly, a key competitor, experienced a brief 1.2% dip in U.S. markets before closing 2.45% higher.

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Eli Lilly is also making strides with its oral weight-loss pill, orforglipron, which demonstrated a 14.7% weight loss over 36 weeks in a mid-stage trial. Oral treatments are gaining traction due to their convenience and cost-effectiveness compared to injectable therapies.

Novo Nordisk is developing an oral version of amycretin, showing a 13.1% weight reduction in trials, although this formulation presented more side effects. Its oral semaglutide trials reported a 15% weight loss over 68 weeks.

Outlook

With amycretin’s promising results and Wegovy’s robust sales, which rose 79% year-on-year in Q3, Novo Nordisk is poised for growth in the weight-loss drug market. The company’s fourth-quarter and full-year earnings are set to be released on February 5, offering further insights into its performance amid intensifying competition.

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Spain’s Housing Market Faces Growing Pressure as Big Landlords Expand

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A lack of transparency over property ownership is making it difficult to determine how much housing is controlled by large landlords in Spain, even as major investors continue to make significant purchases across the country.

Public data does not provide a complete picture of residential properties owned by companies or individuals with more than 10 homes or 1,500 square metres of residential space. Although the national cadastre holds ownership records, the information is anonymised, limiting efforts to identify the largest landlords and track changes in their portfolios.

Rental-market data can sometimes be obtained through transparency requests to Spain’s autonomous communities, which oversee tenant deposit records. However, such information excludes owner-occupied and vacant properties as well as other categories of housing, making it difficult to establish the full scale of corporate ownership in real time.

Property transactions announced by companies during 2026 nevertheless show continued activity among major investors. The biggest deal so far involved Fidere, a group of listed real estate investment trusts focused on public and rental housing. Canadian investment group Brookfield bought Fidere from Blackstone in March for €1.05 billion, acquiring 47 buildings containing more than 5,000 rental homes.

In May, Azora agreed to acquire 1,200 rental homes in the Barcelona metropolitan area from Patrizia for more than €350 million. Patrizia had purchased the properties from BeCorp in 2022 for about €600 million.

Other deals involve homes that have yet to be completed. Barings is due to acquire 305 affordable homes from Aurora Homes in Madrid’s Los Cerros development for more than €70 million, with completion expected in 2029. It is also buying 188 homes in Valdebebas for more than €56 million from Grupo Ferrocarril.

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Public authorities are also granting concessions on public land to private housing companies, sometimes for periods of 45 to 75 years. This is taking place while Spain’s social rental housing stock remains at just 1.72%, compared with an estimated European average of 8% to 9%.

Culmia, controlled by US investment firm Oaktree, has been involved in several such transactions. In 2025, it transferred a Madrid Plan Vive social housing portfolio to German asset manager DWS through a €255 million transaction. MEAG has also acquired a 50% stake from Culmia in a portfolio containing more than 1,700 homes across Madrid and Valencia.

At the same time, Spain’s wider housing market is showing signs of slower sales growth. Cushman & Wakefield reported a 3.51% annual decline in transactions through May 2026, to about 286,000. BBVA Research expects transactions to fall 7.3% this year before rising 0.6% in 2027.

Despite weaker sales, investment in rental housing has surged. Cushman & Wakefield recorded €2.934 billion in transactions involving large landlords and investment funds during the first half of 2026, a 376% increase from a year earlier.

The figures reflect different parts of the market, as a small number of large portfolio purchases can sharply increase investment volumes without indicating an equivalent rise in the number of individual home sales.

Housing has also become Spain’s leading public concern. According to the September CIS barometer, 37.5% of respondents identified housing as the country’s main problem, ahead of economic issues at 21.6% and immigration at 19.7%.

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Oxfam Calls for Reform of France’s Dutreil Pact to Raise Billions

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Oxfam France has called for a major reform of the country’s Dutreil tax pact, arguing that changes to the scheme could generate billions of euros for public finances by increasing taxation on the largest business inheritances.

The proposal comes as France begins preparations for its 2027 budget amid mounting pressure to reduce the deficit and contain rising public debt. In a report published on Tuesday, September 22, Oxfam identified large inheritances as a potential source of additional government revenue.

The Dutreil pact, introduced in 2003 under then Trade and Crafts Minister Renaud Dutreil, provides a 75% exemption from gift and inheritance taxes when eligible businesses are transferred to heirs. The scheme was designed to help families pass businesses to the next generation without being forced to sell them to meet tax liabilities.

Beneficiaries must meet conditions including retaining their shares for a specified period and maintaining certain business activities. France’s 2026 finance law tightened some of the rules by extending the required holding period and excluding certain assets that are not directly related to business operations.

Oxfam said transfers made under the Dutreil pact have represented almost €3 billion in annual tax expenditure on average over the past four years, with the figure reaching €5.5 billion in 2024, citing the French Court of Audit.

The organisation estimates that transferring the wealth of French billionaires aged over 70 through the scheme could result in more than €111 billion in lost public revenue over the next 30 years if current rules remain unchanged. Oxfam stressed that this is a projection and not an amount the government would automatically collect if the scheme were abolished.

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The group argues that the tax benefit is particularly concentrated among the wealthiest recipients. According to its calculations, the 110 most advantaged beneficiaries, representing about 1% of recipients, saved an average of €30 million each in tax in 2024. Meanwhile, half of the least advantaged beneficiaries saved less than €40,000 on average.

Oxfam proposes limiting the Dutreil exemption to €1 million per beneficiary. It estimates that about 90% of current beneficiaries would remain unaffected by the proposed cap, while the state could raise more than €3 billion annually.

The debate is expected to form part of discussions surrounding France’s 2027 finance bill. Any reform would need to balance additional tax revenue against the original purpose of the Dutreil pact, which is to facilitate the transfer of family businesses.

Layla Abdelke Yakoub, Oxfam France’s Advocacy Manager for Tax Justice and Inequality, said Prime Minister Sébastien Lecornu had indicated that the government would not change the Dutreil pact.

Oxfam said it hoped the government would reconsider its position and called for the largest fortunes to make a greater contribution to France’s fiscal effort.

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Volkswagen Removed From Euro Stoxx 50 After Profit Warning

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Volkswagen has been removed from the Euro Stoxx 50, the benchmark index of major companies listed in the eurozone, adding pressure on Europe’s biggest carmaker just days after it issued a major profit warning.

The change took effect when European markets opened on Monday following an annual review by index provider Stoxx. Volkswagen was replaced by Finnish telecoms group Nokia, while French utility Engie joined the index. Dutch information services company Wolters Kluwer was also removed.

Volkswagen’s departure from the index was based on its falling free-float market value rather than a specific assessment of its business performance. The Euro Stoxx 50 is weighted according to the market value of shares available for public trading, meaning Volkswagen no longer met the required threshold.

The move could still affect the company’s shares because investment funds that track the index are required to adjust their portfolios. That can result in additional selling pressure on stocks removed from the benchmark.

Volkswagen shares have fallen almost 30% since the beginning of the year and were down more than 6% from last Monday’s opening. The shares were trading at around €76.

The index change came shortly after Volkswagen issued a warning about its financial outlook. On Friday, the company said one-off charges of about €10 billion would significantly reduce its 2026 earnings.

Volkswagen lowered its operating margin forecast to no more than 1%, compared with its previous guidance of between 4% and 5.5%. Analysts had been expecting a margin of about 4.1%.

More than €6 billion of the charges are linked to a writedown at Porsche, in which Volkswagen owns a 75.4% stake. Porsche has faced weaker demand in China and the impact of US tariffs on its business. Its operating margin was only 1.1% last year.

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Volkswagen also expects more than €2 billion in charges related to expanded early retirement programmes, impairments in China and the planned sale of its Osnabrück manufacturing subsidiary.

The company cited a worsening market environment, particularly in China, as well as a faster shift in consumer demand toward battery-electric vehicles.

The warning followed a restructuring agreement announced two weeks earlier that would double planned job reductions to 100,000 and reduce Volkswagen’s model range by half.

Volkswagen said its underlying operating margin, excluding the one-off charges, was around 4%. It also maintained its forecasts for cash flow and liquidity.

Deutsche Bank said the headline figures overstated the deterioration in Volkswagen’s underlying business, although it expects the restructuring process to remain costly and complex.

Volkswagen is due to report its third-quarter results on October 29, when investors will receive a fuller picture of the company’s financial performance and restructuring plans.

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