Health
Twice-Yearly HIV Prevention Jab Clears Major Hurdle in Europe
European regulators have taken a major step toward approving a groundbreaking HIV prevention treatment, with a twice-yearly injection from U.S. drugmaker Gilead Sciences receiving a positive opinion from the European Medicines Agency (EMA).
The injectable drug, known as lenacapavir, has been hailed as a “game-changer” in the global fight against HIV. Designed as a long-acting form of pre-exposure prophylaxis (PrEP), the treatment has shown 100% effectiveness in preventing HIV in clinical trials. It works by preventing the virus from replicating and spreading in the body, offering protection for both adults and adolescents.
The EMA’s advisory committee issued its endorsement last Friday, paving the way for formal approval by the European Commission later this year. Once authorized, lenacapavir will be marketed in the EU under the name Yeytuo.
“This milestone reflects our commitment to reimagine HIV prevention in Europe and around the world,” said Dr. Dietmar Berger, Chief Medical Officer at Gilead Sciences. “Lenacapavir for PrEP has the potential to become a critical tool for public health, helping to expand prevention options for people who face the highest barriers to care.”
Unlike existing daily oral PrEP medications, lenacapavir requires only two injections per year, making it a more convenient option and potentially improving adherence among at-risk populations.
Despite significant advancements in treatment and awareness, HIV continues to pose a public health challenge. In 2023, the number of new HIV diagnoses in the EU, along with Iceland, Liechtenstein, and Norway, rose to over 24,700—an 11.8% increase from the previous year.
Lenacapavir was also approved by the U.S. Food and Drug Administration (FDA) last month. While its rollout is expected to begin in Europe soon after final approval, global accessibility remains a concern.
Gilead has agreed to license generic versions of the drug for use in 120 low- and middle-income countries with high HIV prevalence. However, the extent of global distribution is uncertain following significant funding cuts to international health programs by the United States earlier this year.
The European Commission, which will make the final decision on market authorization, has not yet issued a formal response. The EMA also declined to comment further at this stage.
If approved, lenacapavir would mark a major shift in HIV prevention strategies across Europe, potentially reaching those who struggle with daily medication regimens and expanding protection at a time when new infections are once again on the rise.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
Europe Records Sharp Rise in Sexually Transmitted Infections, ECDC Warns
Health
White House Rejects Report It Blocked Return of Ebola-Infected US Doctor
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