Health
Twice-Yearly HIV Prevention Jab Clears Major Hurdle in Europe
European regulators have taken a major step toward approving a groundbreaking HIV prevention treatment, with a twice-yearly injection from U.S. drugmaker Gilead Sciences receiving a positive opinion from the European Medicines Agency (EMA).
The injectable drug, known as lenacapavir, has been hailed as a “game-changer” in the global fight against HIV. Designed as a long-acting form of pre-exposure prophylaxis (PrEP), the treatment has shown 100% effectiveness in preventing HIV in clinical trials. It works by preventing the virus from replicating and spreading in the body, offering protection for both adults and adolescents.
The EMA’s advisory committee issued its endorsement last Friday, paving the way for formal approval by the European Commission later this year. Once authorized, lenacapavir will be marketed in the EU under the name Yeytuo.
“This milestone reflects our commitment to reimagine HIV prevention in Europe and around the world,” said Dr. Dietmar Berger, Chief Medical Officer at Gilead Sciences. “Lenacapavir for PrEP has the potential to become a critical tool for public health, helping to expand prevention options for people who face the highest barriers to care.”
Unlike existing daily oral PrEP medications, lenacapavir requires only two injections per year, making it a more convenient option and potentially improving adherence among at-risk populations.
Despite significant advancements in treatment and awareness, HIV continues to pose a public health challenge. In 2023, the number of new HIV diagnoses in the EU, along with Iceland, Liechtenstein, and Norway, rose to over 24,700—an 11.8% increase from the previous year.
Lenacapavir was also approved by the U.S. Food and Drug Administration (FDA) last month. While its rollout is expected to begin in Europe soon after final approval, global accessibility remains a concern.
Gilead has agreed to license generic versions of the drug for use in 120 low- and middle-income countries with high HIV prevalence. However, the extent of global distribution is uncertain following significant funding cuts to international health programs by the United States earlier this year.
The European Commission, which will make the final decision on market authorization, has not yet issued a formal response. The EMA also declined to comment further at this stage.
If approved, lenacapavir would mark a major shift in HIV prevention strategies across Europe, potentially reaching those who struggle with daily medication regimens and expanding protection at a time when new infections are once again on the rise.
Health
World Cup Emotion Can Strain the Heart, Cardiologists Warn Fans at Risk
As the World Cup begins, medical experts are cautioning football fans with underlying heart conditions that the emotional intensity of matches can place unexpected strain on the cardiovascular system.
Cardiologists say that the excitement, tension, and anxiety generated during high-stakes games can trigger physical reactions similar to intense exercise, raising heart rate, blood pressure, and stress hormones.
“Intense emotions, whether positive or negative, can act as ‘precipitating risk factors’ for cardiovascular events such as heart attack,” said Paola Santalucia, a cardiologist and board member of the European Heart Network.
She explained that moments of extreme excitement, such as a decisive penalty shootout or a last-minute goal, may pose risks for people already living with heart disease. Those with additional risk factors, including hypertension, obesity, or smoking habits, are also advised to be cautious during emotionally charged matches.
Research using wearable devices has shown that during major football events, some fans experience heart rates climbing as high as 150 beats per minute. That level is comparable to sprinting and reflects how strongly the body reacts to emotional stress.
A study examining supporters during the 2025 German Cup final found that even watching from home can significantly affect physiological responses. “They still had an increase in heart rate that compares to walking, even though they didn’t walk,” said Christian Deutscher, professor of sports economics at Bielefeld University and co-author of the study.
He noted that the most intense reactions often occur not during goals themselves, but during moments of uncertainty such as VAR checks, penalty shootouts, or shots striking the post. These unpredictable situations, he said, are what drive the strongest emotional and physical responses among fans.
Deutscher also pointed out that stadium spectators may experience even greater strain due to environmental factors such as heat and alcohol consumption.
However, experts emphasize that football itself is not inherently dangerous. Instead, it is the body’s natural response to excitement that can create temporary stress.
“The adrenergic stimulation is at its max: extreme high blood pressure, high heart rate, and adrenaline, cortisol, skyrocketing,” said Dan Atar, professor of cardiology at Oslo University Hospital. In rare cases, he added, this surge can contribute to the rupture of arterial plaque in vulnerable individuals, potentially leading to a heart attack.
Atar stressed that such events can occur in everyday situations as well, including physical exertion like shoveling snow. “It is in no way dangerous to watch a football game,” he said. “All this is physiologic. It’s not dangerous to be excited.”
Still, he acknowledged that combining emotional stress with alcohol, heat, and pre-existing conditions can increase risk for some viewers.
Doctors advise those at higher risk to continue prescribed medications, limit alcohol intake, avoid smoking, and watch for warning signs such as chest pain or irregular heartbeat.
“The key message is not to avoid enjoying the match, but to do so with moderation and awareness,” Santalucia said.
Health
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Health
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