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New RNA Modification Could Make mRNA Medicines More Powerful, Scientists Say

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A small chemical change to messenger RNA could help future vaccines and medicines produce more therapeutic proteins inside cells, according to researchers at Johns Hopkins Medicine.

Scientists have identified a potential alternative to the RNA modification widely used in current mRNA technology. Their research suggests that replacing N1-methylpseudouridine, known as m1Ψ, with a naturally occurring modification called N4-acetylcytidine, or ac4C, could increase the speed at which cells translate mRNA into proteins.

The findings were published in the journal Nature and could eventually have implications for vaccines and treatments being developed for infectious diseases, cancer and autoimmune conditions.

The current leading mRNA platform uses m1Ψ, which became widely known through the COVID-19 vaccines. Researchers are now investigating the technology for a much broader range of medical applications.

The Johns Hopkins team compared the two modifications in cultured human dendritic cells and mouse liver cells. They found that ribosomes, the structures responsible for reading mRNA and producing proteins, moved considerably faster along ac4C-modified mRNA.

“Our results show that ac4C causes cells to produce more therapeutic proteins than the industry standard mRNA platform,” said Bin Wu, an associate professor of biophysics and biophysical chemistry at the Johns Hopkins University School of Medicine.

The researchers found that ribosomes travelled almost twice as fast on ac4C-modified mRNA compared with m1Ψ-modified mRNA.

Wu compared the difference to traffic congestion. When ribosomes move more slowly, they can build up along an mRNA strand and create what researchers describe as a molecular traffic jam. Faster movement could allow more ribosomes to process the same strand efficiently, increasing protein production.

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The potential benefit could be significant for mRNA medicines. These treatments work by giving cells temporary genetic instructions to produce specific proteins. The amount of protein generated can influence whether a treatment reaches the level needed to produce a therapeutic effect.

If ac4C allows cells to produce more protein from the same amount of mRNA, future therapies could potentially require smaller doses. That could reduce the amount of material needed for some treatments while improving their effectiveness.

Researchers point out that more than 170 RNA modifications are known to exist, but only a limited number have been extensively investigated for use in mRNA therapies.

The discovery could open another area of research as scientists seek to improve the performance of mRNA technology. Potential applications include vaccines against infectious diseases, cancer treatments that activate immune responses and therapies designed to modify immune activity in autoimmune disorders.

However, ac4C is still at an experimental stage. The findings have so far been demonstrated in laboratory and animal cells, meaning further studies will be needed to determine whether the modification is safe and effective in living organisms.

If future research confirms the results, the chemical change could become an important step in improving the next generation of mRNA-based medicines.

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Breast Cancer Screening Gaps Across Europe Leave Women Facing Unequal Access to Early Diagnosis

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A breast biopsy can bring days of uncertainty, fear and difficult memories, particularly for women with a family history of cancer. For Euronews reporter Monica Pinna, a week-long wait for test results became a personal experience of the emotional strain involved in investigating a possible diagnosis, as well as the inequalities affecting breast cancer screening and care across Europe.

Pinna had delayed a routine breast examination for around two years before attending an appointment in France. Her mammogram appeared normal, but an ultrasound revealed a suspicious area that required a biopsy. She underwent the procedure two days later and waited seven days for the results.

During that period, she recalled relatives who had survived breast cancer and others who had died from the disease. Although the uncertainty disrupted her work and daily life, the doctor eventually confirmed that there was no cancer.

Her experience highlighted a wider problem: access to early detection and timely diagnosis varies considerably between European countries.

When breast cancer is detected before it spreads, five-year survival rates approach 100%, compared with 38% for women diagnosed at an advanced stage, according to figures cited in the report. The European Commission has allocated around €80 million through its Europe’s Beating Cancer Plan to strengthen screening, but access remains uneven.

Differences in screening arrangements, appointment availability, out-of-pocket costs and public awareness all affect women’s chances of receiving an early diagnosis. Research by the European Union and the Organisation for Economic Co-operation and Development (OECD) has also identified social inequalities as a factor.

The time between screening and diagnosis varies across the continent. A study cited in the report found median waiting times ranging from eight days in Denmark to 32 days in Romania.

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Maria Assunta, who lives in Sardinia, experienced a considerably longer process. At 46, a routine ultrasound identified a four-centimetre lump. She waited a month for a biopsy and another three weeks to receive her diagnosis. She is now in follow-up care, with examinations every six months, and describes the treatment she received as excellent.

Participation in organised screening programmes also remains inconsistent. In France, fewer than half of eligible women take part. Although screening rates increased in nine EU countries with available data compared with 2019, progress has stalled in many others.

Around 360,000 women in the EU are diagnosed with breast cancer each year, including approximately 61,000 in France. Estimates suggest that one in 11 women will develop the disease during their lifetime.

Access to psychological support is another concern. The OECD’s 2026 European Cancer Inequalities Report found that only 16 EU countries include psychological care in their cancer treatment pathways, alongside Norway and Iceland.

In Italy, a 2024 study of around 3,000 cancer patients found that only 20% had received psychological support. The Italian Federation of Voluntary Associations in Oncology estimates that specialised psycho-oncology services are available in only around 20% of hospitals.

Cancer survivors and medical volunteers have established initiatives to help address these gaps, offering activities such as yoga, Qigong and emotional support. However, provision remains limited and often depends on voluntary organisations.

Pinna’s experience ended with an all-clear, but she said it had changed her approach to screening. She hopes sharing her story will encourage women to attend regular examinations, while calling for faster diagnosis, wider access to treatment and psychological support across Europe.

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Pilot Fatigue Raises Safety Concerns as Survey Finds Widespread Microsleeps

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Pilot fatigue remains a significant aviation safety concern, with a new survey finding that many pilots continue flying while exhausted rather than declaring themselves unfit for duty because of concerns about their employers’ reactions.

The European Cockpit Association (ECA) said fear of career consequences, reluctance to draw attention to fatigue and concerns about inconveniencing employers were among the main barriers preventing pilots from reporting that they were too tired to fly.

The survey, conducted by aviation consultancy Baines Simmons, collected responses from 7,200 pilots across 32 countries. More than half of respondents said they had flown while tired, while over 76% reported experiencing at least one microsleep on the flight deck during the previous four weeks.

Microsleeps are brief, involuntary episodes of sleep that can occur when a person is severely fatigued. Other warning signs include head nodding, difficulty keeping the eyes open and reduced alertness, all of which can compromise a pilot’s ability to respond to changing conditions during a flight.

More than half of the pilots surveyed said that, at least once in the previous three months, they had operated a flight before later realising they should have declared themselves unfit for duty because of fatigue.

Concern about management’s reaction was the most frequently reported barrier, cited by 47% of respondents. Another 44% said they did not want to draw attention to themselves, while 35% were reluctant to inconvenience their employer.

“When pilots fear career consequences, fatigue goes unreported and the risk returns to the cockpit,” said Captain Coen George, an ECA board director.

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Fatigue can result from insufficient sleep, long or demanding duty periods and inadequate recovery time between assignments. The report also highlighted cumulative fatigue, which builds up over successive duties and can be harder for pilots to recognise before their performance is affected.

Despite widespread awareness of the risks, confidence in reporting procedures remains low. Although 82% of respondents knew how to submit a fatigue report, only 12% said they trusted the reporting system. Just 11% said fatigue reports had resulted in operational changes intended to improve safety.

Half of those surveyed described fatigue risks at their airlines as poorly managed or not managed at all.

The findings echo concerns raised by the European Union Aviation Safety Agency (EASA), which identified aircrew fatigue as a prominent safety issue in a report published in June 2026.

EASA linked fatigue to several operational and employment-related factors, including flight scheduling, short-notice roster changes and the use of commanders’ discretion to extend duty periods beyond planned limits.

The agency called for targeted safety initiatives to improve reporting and awareness, alongside workplace cultures that allow personnel to declare themselves too tired to work without fear of reprimand.

The ECA survey suggests that improving formal reporting procedures alone may not be sufficient. Building trust in those systems and ensuring that fatigue reports lead to meaningful operational changes remain important challenges for airlines seeking to protect flight safety.

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One in Three Young US Adults Uses AI for Drug Information, Study Finds

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One in three young adults in the United States has used artificial intelligence chatbots to seek information about drugs and alcohol, raising concerns among researchers about the potential health risks of inaccurate or misleading advice.

A study published in JMIR Formative Research found that 32% of 995 adults aged 18 to 29 had used tools such as ChatGPT, Google Gemini and Meta AI to obtain information related to substance use.

Among those who used AI for this purpose, nearly half said they did so at least once a month. About 12% reported using chatbots for substance-related information weekly, while 4% said they used them daily or almost daily.

“Using these tools can lead to misinformed or otherwise risky substance-use behaviour among young people, who are the age group most affected by adverse effects of substance use,” said Mireia Triguero Roura, a postdoctoral researcher at Rutgers University and lead author of the study.

The survey was conducted online in April 2026. Researchers found that AI users were primarily seeking information about the risks and consequences of substance use. Nearly 93% of respondents who had asked chatbots substance-related questions cited this as a reason.

Around half sought information about specific substances, including questions about dosage, while 35% used AI to explore substance use disorders and addiction.

The findings suggest that chatbots are supplementing rather than replacing traditional online searches. Among respondents who had used AI for substance-related information, 93% had also used Google search for similar purposes.

Participants generally rated AI tools positively for helpfulness, reliability and trustworthiness. Those who used chatbots for substance-related questions gave them an average trustworthiness score of 3.66 out of five, compared with 3.51 for general use.

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Researchers cautioned, however, that positive user perceptions do not establish whether chatbot responses are medically accurate or safe. Incorrect information about substances, their effects or appropriate responses to health risks could influence decisions and encourage harmful behaviour.

The study also identified differences in use according to race and sex. Black respondents had 2.52 times the adjusted odds of reporting substance-related AI use compared with white respondents. Male respondents had approximately twice the adjusted odds of female respondents.

Triguero Roura said these differences could reflect variations in access to healthcare, experiences of stigma, trust in health services and patterns of seeking health information.

The researchers said further studies are needed to assess the accuracy of chatbot answers to drug-related questions and determine how users interpret and act on the information they receive.

They also called for more research into why certain demographic groups are more likely to use AI for substance-related queries.

As generative AI becomes a more common source of information for young adults, the findings highlight the need to understand whether these tools can provide reliable health guidance and how potential risks can be reduced.

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