Health
Study Finds Intensive Blood Pressure Control Reduces Risk of Heart Attack and Stroke
Intensifying efforts to lower high blood pressure can significantly reduce the risk of heart attack, stroke, and related deaths, according to a new large-scale study published in The Lancet medical journal.
Hypertension, or high blood pressure, is one of the most common chronic health conditions globally, affecting an estimated 1.28 billion adults aged 30 to 79. If untreated, it can lead to serious complications including heart disease, stroke, and kidney failure. Standard treatment typically involves medication and lifestyle changes to lower systolic blood pressure—the top number in a reading—to around 140 millimetres of mercury (mmHg).
The new research suggests that lowering blood pressure even further, to below 120 or 130 mmHg, may deliver greater cardiovascular benefits. The study, led by a Chinese research team, analysed data from around 80,000 people across six clinical trials conducted in China, Canada, and the United States. Participants underwent varying treatment strategies, combining medication with lifestyle adjustments such as regular exercise, weight management, smoking cessation, and dietary improvements.
The analysis found that participants receiving intensive blood pressure control were less likely to suffer heart attacks, strokes, or cardiovascular-related deaths compared with those who followed standard treatment targets. “Our findings indicate a net benefit to intensive blood pressure management,” the authors noted, calling it the most comprehensive review to date of the approach’s health effects.
However, the study also highlighted potential drawbacks. Those in the intensive treatment group experienced higher rates of side effects, including dizziness, fainting, kidney issues, and irregular heart rhythms. These risks have fueled ongoing debate within the medical community about how aggressively to pursue lower blood pressure goals, particularly among older adults who may be more vulnerable to falls and complications.
The researchers stressed the importance of tailoring treatment to each patient. “The results underscore the need for individualised strategies to optimise outcomes while avoiding both overtreatment and undertreatment,” the study concluded.
Medical experts say the findings could influence future guidelines for hypertension management, as healthcare providers weigh the benefits of stricter control against the risks of side effects. With nearly half of global adults unaware they have high blood pressure, and only a fraction receiving effective treatment, the study reinforces the urgency of early diagnosis and careful monitoring.
As the debate continues, doctors are being urged to balance aggressive blood pressure control with patient safety, taking into account age, overall health, and individual risk factors.
Health
Medieval Manuscripts Reveal Thousands-Year History of Deadly Sheep Virus
DNA recovered from medieval manuscripts has given scientists new clues about the long history of sheep pox, a highly contagious disease that has threatened livestock for thousands of years.
An international team led by researchers at University College Dublin discovered traces of sheep pox virus in parchment used for some of Europe’s historic manuscripts. The findings suggest that animal diseases may have left genetic records in old documents, providing scientists with another way to study how pathogens developed over time.
During the Middle Ages, parchment was commonly made from the treated skin of sheep, goats and cattle. Researchers extracted DNA from the animal skins used to produce centuries-old manuscripts and identified genetic material linked to the sheep pox virus.
The study involved geneticists, historians, virologists, protein chemists and conservation specialists. Louis L’Hôte, the study’s lead author, said the research showed that parchment could preserve DNA from animal pathogens and provide valuable evidence about infectious diseases in the past.
Among the manuscripts examined was the approximately 1,000-year-old York Gospels, considered one of the finest surviving illuminated manuscripts from the late Anglo-Saxon period. Researchers also examined the Corpus Glossary at Corpus Christi College in Cambridge, an early English dictionary, along with other medieval texts from Britain and continental Europe.
In some manuscripts, several pages contained sheep pox virus DNA. Researchers said this could indicate that animals infected with the disease were used to produce the parchment.
The team compared the genetic material recovered from the manuscripts with older DNA samples obtained from Bronze Age sheep teeth. Their analysis indicated that sheep pox has affected livestock for more than 3,700 years.
Sheep pox spreads quickly among animals and can infect a large proportion of a flock. The disease causes fever and skin lesions and can result in death. Outbreaks can also cause major financial losses through reduced milk production, damage to wool and hides, and restrictions on livestock trade.
There is no evidence that sheep pox infects humans.
The research, published in Science Advances, also provided insight into how the virus changed over time. Scientists found that the sheep pox virus genome remained relatively stable during the past several thousand years.
L’Hôte said the finding contrasts with the evolutionary history of some other pathogens, including smallpox. The stability of the sheep pox genome may indicate that important genetic changes occurred much earlier in the virus’s history and helped it adapt to sheep.
Researchers said the work could encourage scientists to examine other archives and libraries for genetic traces of historic animal diseases. Ancient DNA preserved in manuscripts could offer a new source of information about outbreaks that affected livestock and societies long before modern disease surveillance existed.
Health
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Health
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