Health
New Study Warns Tattoo Ink May Influence Immune Response and Disease Resistance
A major scientific study has raised fresh concerns about the impact of tattoo inks on the body’s immune system, suggesting that the pigments used to create tattoo designs may interfere with how the body responds to disease and vaccination.
Researchers at the Institute for Research in Biomedicine at the Università della Svizzera italiana (USI) examined the toxicity of pigments used in the three most common tattoo colours: black, red and green. The study, published in the journal PNAS, is being described by the team as the most extensive investigation yet into how tattoo inks interact with immune cells.
The scientists found that pigment does not remain confined to the skin. Instead, particles travel through the body and collect in immune tissues, where they can persist for years. Once inside these tissues, the ink triggers cell damage. Macrophages — immune cells responsible for clearing foreign substances — are unable to break down the pigment, leading to swelling and prolonged strain on the immune system.
Pigments used in red and black tattoos caused the strongest reactions in laboratory tests.
When the researchers examined tattooed mice, they recorded rapid movement of pigment to the lymph nodes, where it continued to accumulate for at least two months. The altered immune activity appeared to affect how the animals responded to vaccines. In tests, the mice showed a weaker response to COVID-19 vaccines after tattooing, although the same pigments appeared to strengthen the response to a UV-inactivated flu vaccine.
Scientists stressed that more work is needed to confirm these findings in humans and across a wider range of vaccines. The International Agency for Research on Cancer (IARC) is conducting separate research into possible long-term risks, including links between tattoo pigments, the immune system, and cancers such as lymphomas.
Researchers note that many pigment particles are extremely small, allowing them to circulate beyond the dermis, the layer of skin where tattoos are placed. This raises the possibility that exposure is not limited to the area of the tattoo.
Tattooing has become increasingly common, especially in Europe and the United States, where up to 40 percent of adults under 40 have at least one tattoo. IARC has said that the growth of the tattoo industry has turned pigment safety into a rising public health concern.
Tattoo ink can contain up to 100 chemical substances. Black ink usually contains carbon-based pigments, while coloured designs often rely on industrial pigments originally meant for plastics or paints. Europe introduced new rules in 2022 under its REACH chemical safety regulation to bring stricter oversight to ingredients used in tattoo inks.
With tattoo popularity rising worldwide, scientists say understanding these biological effects is becoming increasingly important.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
Europe Records Sharp Rise in Sexually Transmitted Infections, ECDC Warns
Health
White House Rejects Report It Blocked Return of Ebola-Infected US Doctor
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