Health
Study Reveals Why Weight Loss Is Often Followed by Regain: The ‘Yo-Yo’ Effect Explained
Losing weight can be an arduous process, with many individuals finding it difficult to maintain their weight loss over time. This phenomenon, known as the “yo-yo effect,” has long perplexed researchers. A new study from ETH Zurich in Switzerland offers a molecular explanation for why keeping weight off can be so challenging.
Published in the journal Nature, the study highlights how the body’s fat cells retain a “memory” of obesity, even after significant weight loss. This memory is linked to epigenetics, a process where changes in gene activity occur due to environmental factors like diet and lifestyle.
The study suggests that when a person is overweight, their fat cells may develop lasting epigenetic markers that remain even after weight loss. These markers disrupt the normal function of fat cells, making them more likely to store fat and respond to dietary changes in ways similar to when the person was obese. As a result, despite losing weight, the body behaves as though it is still in an overweight state, which could contribute to the difficulty in maintaining weight loss.
To reach these conclusions, the researchers studied fat tissue samples from individuals who had undergone weight-loss surgeries, such as gastric bypass or stomach reduction. They found that even two years after surgery, the fat cells of these individuals continued to behave as if they were still overweight.
In addition, the team conducted an experiment with mice to observe similar effects. After making the mice obese by feeding them a high-fat diet, the researchers switched them to a standard diet to induce weight loss. The mice showed that their fat cells retained markers of obesity even after losing weight. When reintroduced to a high-fat diet, these mice regained weight more quickly, and it was easier for them to become obese again.
While the researchers did not investigate how long this “cell memory” lasts, co-author Laura Hinte noted that fat cells are long-lived and can persist for up to ten years before being replaced by new ones.
Ferdinand von Meyenn, a professor of nutrition and metabolic epigenetics at ETH Zurich, emphasized the importance of preventing obesity in the first place. He explained, “It’s precisely because of this memory effect that it’s so important to avoid being overweight in the first place. Because that’s the simplest way to combat the yo-yo phenomenon.”
This groundbreaking study provides new insight into the biological factors behind weight loss struggles, offering hope for more effective strategies to combat the yo-yo effect in the future.
Health
Global Mental Health Cases Near 1.2 Billion as Anxiety and Depression Drive Sharp Worldwide Rise
A major global analysis has found that mental health conditions have surged to an estimated 1.2 billion people worldwide, driven largely by steep increases in anxiety and depression over the past three decades.
The findings, published in The Lancet as part of the Global Burden of Disease Study 2023, show that the number of people living with mental disorders has almost doubled since 1990, marking a 95% rise. Researchers say major depressive disorder and anxiety disorders have seen even sharper growth, increasing by 131% and 158% respectively, making them the most prevalent mental health conditions globally.
The report describes mental illnesses as widespread conditions that create long-term disability and significant human suffering. It also highlights broader consequences for economies and public services, including reduced productivity, lower workforce participation and increasing pressure on health and welfare systems.
Researchers estimate that in 2023 alone, around 620 million females and 552 million males were affected by mental health conditions. While the overall burden is rising across both sexes, the study points to notable differences in the types and prevalence of disorders.
Among women, depression and anxiety were the most commonly reported conditions, alongside higher rates of eating disorders such as anorexia nervosa and bulimia nervosa. The report links this disparity to a mix of biological, social and structural factors, including exposure to domestic violence, sexual abuse, gender inequality and reproductive health-related changes.
In contrast, neurodevelopmental and behavioural disorders, including attention deficit hyperactivity disorder (ADHD), conduct disorder and autism spectrum conditions, were more frequently diagnosed in men.
Teenagers aged 15 to 19 were identified as the group experiencing the highest mental health burden globally, raising concerns about early onset of conditions and insufficient preventive care for young people.
The study identifies several key risk factors associated with mental illness, including childhood sexual violence, bullying and intimate partner violence. These factors are strongly linked to conditions such as depression, schizophrenia, bipolar disorder and anxiety disorders. However, researchers note that such exposures have remained relatively stable over time and account for only a portion of the overall rise.
According to the authors, broader drivers are likely contributing to the increasing prevalence of mental disorders. These include genetic and biological influences, poverty, inequality, and the growing impact of global crises such as armed conflict, pandemics, natural disasters and climate-related stress.
While mental health conditions have long been a leading cause of disability worldwide, the report warns that the situation is worsening. At the same time, health systems have not expanded services at a pace matching demand.
The authors caution that the gap between rising need and limited access to care is becoming more pronounced, leaving millions without adequate treatment or support.
Health
Europe Records Sharp Rise in Sexually Transmitted Infections, ECDC Warns
Health
White House Rejects Report It Blocked Return of Ebola-Infected US Doctor
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