Health
UK Scientists Uncover Breakthrough in Asthma and COPD Treatment
A new treatment approach for asthma and chronic obstructive pulmonary disease (COPD) has been identified by scientists in the UK, marking what is being hailed as the first major advancement in managing these conditions in half a century.
The findings, published in The Lancet Respiratory Medicine, reveal that a single injection of benralizumab, a monoclonal antibody, is significantly more effective than traditional steroid tablets in reducing symptom flare-ups, known as eosinophilic exacerbations. These episodes account for roughly 50% of asthma attacks and 30% of COPD attacks, causing symptoms such as wheezing, coughing, and chest tightness.
A New Approach to Inflammation
Steroid tablets, the conventional treatment, work by reducing inflammation in the lungs but are not effective for all patients and can lead to serious long-term side effects like high blood pressure and osteoporosis. In contrast, benralizumab targets white blood cells to reduce lung inflammation, curbing symptoms and lowering the need for additional treatments by 30%, according to the study.
“This could be a game-changer for people with asthma and COPD,” said Dr. Mona Bafadhel, lead investigator and chair of respiratory medicine at King’s College London.
Widespread Impact
COPD affects an estimated 36.6 million Europeans, while nearly 10 million people under 45 have asthma. These conditions significantly impact patients’ quality of life, particularly older individuals with both diseases, who often face limited life expectancies.
“We need to provide these patients with life-saving options before their time runs out,” said Dr. Sanjay Ramakrishnan, a study author and clinical senior lecturer at the University of Western Australia. He criticized current treatments as being “stuck in the 20th century.”
Trial Highlights
The study divided high-risk asthma and COPD patients into three groups: one received benralizumab, another steroids, and the third both treatments.
After 28 days, those treated with benralizumab showed better respiratory outcomes. At the 90-day mark, 74% of steroid-treated patients required further medical intervention due to treatment failure, compared to only 45% of those who received the antibody injection.
The findings suggest that a single benralizumab injection could become a vital emergency treatment, reducing hospital readmissions for asthma and COPD patients.
A Pivotal Moment in Respiratory Care
“We hope these pivotal studies will change how asthma and COPD exacerbations are treated for the future, ultimately improving the health for over a billion people living with asthma and COPD across the world,” Bafadhel stated.
The trial, supported by AstraZeneca and the University of Oxford, offers renewed hope for better management of respiratory diseases, potentially transforming care for millions globally.
Health
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Health
Obesity Linked to Poorer Outcomes in Childhood Cancer Patients, Study Finds
Children with obesity diagnosed with cancer face significantly worse health outcomes, including a heightened risk of relapse and death, according to a new Canadian study.
The research, published in the journal Cancer, analyzed data from over 11,000 cancer patients aged 2 to 19, of whom 10.5% were obese at diagnosis. The study examined various cancers, including leukemia, lymphoma, and other tumors, and found that obesity negatively impacted outcomes across the entire cohort.
Increased Risk of Relapse and Mortality
The findings revealed that obese children had a 16% higher risk of cancer relapse and a 29% increased risk of death within five years of diagnosis, even after accounting for factors such as age, sex, and ethnicity.
“Our study highlights the negative impact of obesity among all types of childhood cancers,” said Dr. Thai Hoa Tran, a pediatric hematologist and oncologist at the University Hospital Centre Sainte-Justine in Montreal, Canada, and one of the study’s authors.
Dr. Tran emphasized the need for strategies to address obesity’s impact on cancer outcomes in future clinical trials and highlighted the importance of combating the childhood obesity epidemic to prevent severe health consequences.
Acute Lymphoblastic Leukemia and Brain Tumors Most Affected
The study found the impact of obesity was particularly pronounced in children with acute lymphoblastic leukemia (ALL)—a cancer of the blood and bone marrow—and brain tumors. Researchers suggested that fat tissue may play an active role in tumor progression, metastasis, and resistance to treatment.
Previous research has indicated that adipose (fat) tissue cells can promote tumor development and hinder the effectiveness of therapies. Additionally, the study noted concerns about potential undertreatment and inappropriate dosing of chemotherapy in obese patients, which could further compromise outcomes.
Limitations and Calls for Improved Measures
The researchers acknowledged limitations in their study, including reliance on body mass index (BMI) to define obesity. They pointed out that BMI is an imprecise measure that does not fully capture body composition or nutritional status.
“BMI remains a crude and imperfect measure,” the authors wrote, echoing recent calls from experts to adopt more accurate diagnostic tools for obesity. Critics argue that BMI may lead to overdiagnosis or fail to reflect the nuanced impact of weight on health outcomes.
Implications and Urgency
The findings underscore the urgent need for interventions targeting childhood obesity and call for more precise research to better understand the interplay between obesity and cancer treatment. As childhood obesity rates continue to rise globally, addressing this epidemic could have far-reaching implications for improving survival rates and health outcomes for young cancer patients.
Health
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