Health
UK Detects Case of Contagious New Mpox Strain Linked to African Outbreak
A case of the new mpox strain, which has been central to an outbreak in several African nations, has been identified in the United Kingdom, health authorities confirmed. The UK Health Security Agency (UKHSA) reported that the infected patient, recently returned from Africa, is currently receiving treatment in a London hospital. The agency has reassured the public, stating the risk remains low, as it continues efforts to trace close contacts and monitor the situation.
UKHSA Chief Medical Adviser Dr. Susan Hopkins noted, “The risk to the UK population remains low, and we are working rapidly to trace close contacts and reduce the risk of any potential spread.” Mpox, a contagious virus, spreads primarily through close personal contact, including sexual contact. Common symptoms include rash, fever, chills, and swollen lymph nodes. Although mpox is endemic in parts of Central and West Africa and sparked a global outbreak in 2022, this new strain, called clade 1b, appears to spread more easily and has shown an increased impact on children.
The clade 1b strain was first identified in the Democratic Republic of the Congo (DRC) last autumn and has since spread to countries across East Africa, including Burundi, Rwanda, Uganda, and Kenya. This latest case in the UK marks the third detection of the strain in Europe, following cases in Sweden in August and in Germany earlier this month. While European health authorities acknowledged the likelihood of more cases, they echoed UKHSA’s position that the risk to the general public remains minimal.
Despite the currently limited number of cases outside of Africa, virologists are urging caution. Jonathan Ball, a professor of molecular virology at the Liverpool School of Tropical Medicine, stated, “The number of cases reported outside of Africa remains low, but the ability of the clade 1b virus to spread through human-to-human transmission means that this issue cannot be ignored.”
The World Health Organization (WHO) raised concerns over mpox’s spread in August, officially designating the outbreak an international health emergency. In response, several countries and organizations, including the European Union, the United States, and Danish vaccine producer Bavarian Nordic, have pledged to donate 620,000 mpox vaccines to African nations severely impacted by the outbreak. Additionally, Japan has committed to sending three million doses to bolster efforts in containing the virus.
According to the Africa Centres for Disease Control and Prevention (Africa CDC), there have been nearly 46,000 mpox cases and over 1,000 deaths across 18 African countries this year, involving multiple mpox strains.
Ball emphasized the importance of vigilance, saying, “It is unlikely that we will see extensive outbreaks in countries with well-developed public health and surveillance systems, but [the new UK case] is a reminder that we need to do more to address health inequalities worldwide.”
Health
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Health
Obesity Linked to Poorer Outcomes in Childhood Cancer Patients, Study Finds
Children with obesity diagnosed with cancer face significantly worse health outcomes, including a heightened risk of relapse and death, according to a new Canadian study.
The research, published in the journal Cancer, analyzed data from over 11,000 cancer patients aged 2 to 19, of whom 10.5% were obese at diagnosis. The study examined various cancers, including leukemia, lymphoma, and other tumors, and found that obesity negatively impacted outcomes across the entire cohort.
Increased Risk of Relapse and Mortality
The findings revealed that obese children had a 16% higher risk of cancer relapse and a 29% increased risk of death within five years of diagnosis, even after accounting for factors such as age, sex, and ethnicity.
“Our study highlights the negative impact of obesity among all types of childhood cancers,” said Dr. Thai Hoa Tran, a pediatric hematologist and oncologist at the University Hospital Centre Sainte-Justine in Montreal, Canada, and one of the study’s authors.
Dr. Tran emphasized the need for strategies to address obesity’s impact on cancer outcomes in future clinical trials and highlighted the importance of combating the childhood obesity epidemic to prevent severe health consequences.
Acute Lymphoblastic Leukemia and Brain Tumors Most Affected
The study found the impact of obesity was particularly pronounced in children with acute lymphoblastic leukemia (ALL)—a cancer of the blood and bone marrow—and brain tumors. Researchers suggested that fat tissue may play an active role in tumor progression, metastasis, and resistance to treatment.
Previous research has indicated that adipose (fat) tissue cells can promote tumor development and hinder the effectiveness of therapies. Additionally, the study noted concerns about potential undertreatment and inappropriate dosing of chemotherapy in obese patients, which could further compromise outcomes.
Limitations and Calls for Improved Measures
The researchers acknowledged limitations in their study, including reliance on body mass index (BMI) to define obesity. They pointed out that BMI is an imprecise measure that does not fully capture body composition or nutritional status.
“BMI remains a crude and imperfect measure,” the authors wrote, echoing recent calls from experts to adopt more accurate diagnostic tools for obesity. Critics argue that BMI may lead to overdiagnosis or fail to reflect the nuanced impact of weight on health outcomes.
Implications and Urgency
The findings underscore the urgent need for interventions targeting childhood obesity and call for more precise research to better understand the interplay between obesity and cancer treatment. As childhood obesity rates continue to rise globally, addressing this epidemic could have far-reaching implications for improving survival rates and health outcomes for young cancer patients.
Health
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