Health
Tuberculosis Emerges as Leading Infectious Disease, Affecting 10.8 Million People Worldwide
Tuberculosis Emerges as Leading Infectious Disease, Affecting 10.8 Million People Worldwide
In a resurgence that has health officials alarmed, tuberculosis (TB) has once again claimed the title of the world’s deadliest infectious disease, with new cases reaching a record high of 10.8 million in 2023, according to the World Health Organization (WHO). This represents a stark increase from the 10.1 million cases recorded in 2020, illustrating the ongoing challenge in managing this ancient but persistent disease.
TB, a highly contagious airborne infection primarily targeting the lungs, is fueled by factors like undernutrition, HIV, diabetes, smoking, and alcohol abuse. Despite a drop in TB-related deaths, the toll remains high, with 1.25 million fatalities recorded last year, placing TB above COVID-19 as the leading infectious cause of death for the first time in three years.
The global distribution of TB cases highlights significant regional and national disparities. India accounts for 26% of all new cases, followed by Indonesia at 10%, with China, the Philippines, and Pakistan each contributing over 6%. Southeast Asia, Africa, and the Western Pacific emerged as the hardest-hit regions, collectively representing 86% of cases.
“TB occurs in every part of the world,” said Dr. Tereza Kasaeva, head of WHO’s global TB program, during a recent press briefing. “But we are not on track to eliminate it.”
Challenges in Containment
Despite advances in TB treatments, rapid diagnostics, and ongoing vaccine research, Kasaeva expressed concern that global efforts are falling short of the United Nations General Assembly (UNGA) targets set for 2027. These targets aim to provide rapid diagnostic testing and preventive treatment to those at risk, yet only 48% of newly diagnosed TB patients received a rapid test last year. Among high-risk groups, 56% of individuals with HIV and 21% of household contacts of TB patients received preventive care.
Drug-resistant TB remains a significant hurdle. In 2023, an estimated 400,000 people developed multi-drug-resistant TB, though only 44% of these patients were accurately diagnosed and treated. This lack of treatment access is particularly troubling, as drug-resistant TB requires more costly and complicated care. “Drug-resistant TB continues to pose a major public health threat,” Kasaeva warned, underscoring the need for timely access to effective treatments.
Funding Shortfalls Impede Progress
The UNGA has set a funding target of $22 billion to combat TB through prevention, diagnostics, and treatment. However, as of last year, only 26% of this goal had been met, with $5.7 billion allocated worldwide. Research funding is similarly limited, with only $1 billion allocated toward the $5 billion target in 2022. Kasaeva highlighted the pressing need for increased investment, noting that low- and middle-income countries are especially constrained by the current funding gap.
Despite these financial challenges, there are promising developments in TB vaccine research. Six vaccine candidates are in late-stage clinical trials, with the WHO optimistic that a new TB vaccine could become available within the next few years. “We’re seeing clinical trials in the hardest-hit countries, and preparations for vaccine distribution should begin now,” Kasaeva noted, expressing hope for future breakthroughs.
With cases of drug-resistant TB rising and funding for prevention and care lagging, health officials are calling for urgent international support to bridge financial and logistical gaps. The resurgence of TB underscores the need for a comprehensive, well-funded approach to contain what remains a leading cause of death worldwide.
Health
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Health
Obesity Linked to Poorer Outcomes in Childhood Cancer Patients, Study Finds
Children with obesity diagnosed with cancer face significantly worse health outcomes, including a heightened risk of relapse and death, according to a new Canadian study.
The research, published in the journal Cancer, analyzed data from over 11,000 cancer patients aged 2 to 19, of whom 10.5% were obese at diagnosis. The study examined various cancers, including leukemia, lymphoma, and other tumors, and found that obesity negatively impacted outcomes across the entire cohort.
Increased Risk of Relapse and Mortality
The findings revealed that obese children had a 16% higher risk of cancer relapse and a 29% increased risk of death within five years of diagnosis, even after accounting for factors such as age, sex, and ethnicity.
“Our study highlights the negative impact of obesity among all types of childhood cancers,” said Dr. Thai Hoa Tran, a pediatric hematologist and oncologist at the University Hospital Centre Sainte-Justine in Montreal, Canada, and one of the study’s authors.
Dr. Tran emphasized the need for strategies to address obesity’s impact on cancer outcomes in future clinical trials and highlighted the importance of combating the childhood obesity epidemic to prevent severe health consequences.
Acute Lymphoblastic Leukemia and Brain Tumors Most Affected
The study found the impact of obesity was particularly pronounced in children with acute lymphoblastic leukemia (ALL)—a cancer of the blood and bone marrow—and brain tumors. Researchers suggested that fat tissue may play an active role in tumor progression, metastasis, and resistance to treatment.
Previous research has indicated that adipose (fat) tissue cells can promote tumor development and hinder the effectiveness of therapies. Additionally, the study noted concerns about potential undertreatment and inappropriate dosing of chemotherapy in obese patients, which could further compromise outcomes.
Limitations and Calls for Improved Measures
The researchers acknowledged limitations in their study, including reliance on body mass index (BMI) to define obesity. They pointed out that BMI is an imprecise measure that does not fully capture body composition or nutritional status.
“BMI remains a crude and imperfect measure,” the authors wrote, echoing recent calls from experts to adopt more accurate diagnostic tools for obesity. Critics argue that BMI may lead to overdiagnosis or fail to reflect the nuanced impact of weight on health outcomes.
Implications and Urgency
The findings underscore the urgent need for interventions targeting childhood obesity and call for more precise research to better understand the interplay between obesity and cancer treatment. As childhood obesity rates continue to rise globally, addressing this epidemic could have far-reaching implications for improving survival rates and health outcomes for young cancer patients.
Health
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