Health
Study Reveals Why Weight Loss Is Often Followed by Regain: The ‘Yo-Yo’ Effect Explained
Losing weight can be an arduous process, with many individuals finding it difficult to maintain their weight loss over time. This phenomenon, known as the “yo-yo effect,” has long perplexed researchers. A new study from ETH Zurich in Switzerland offers a molecular explanation for why keeping weight off can be so challenging.
Published in the journal Nature, the study highlights how the body’s fat cells retain a “memory” of obesity, even after significant weight loss. This memory is linked to epigenetics, a process where changes in gene activity occur due to environmental factors like diet and lifestyle.
The study suggests that when a person is overweight, their fat cells may develop lasting epigenetic markers that remain even after weight loss. These markers disrupt the normal function of fat cells, making them more likely to store fat and respond to dietary changes in ways similar to when the person was obese. As a result, despite losing weight, the body behaves as though it is still in an overweight state, which could contribute to the difficulty in maintaining weight loss.
To reach these conclusions, the researchers studied fat tissue samples from individuals who had undergone weight-loss surgeries, such as gastric bypass or stomach reduction. They found that even two years after surgery, the fat cells of these individuals continued to behave as if they were still overweight.
In addition, the team conducted an experiment with mice to observe similar effects. After making the mice obese by feeding them a high-fat diet, the researchers switched them to a standard diet to induce weight loss. The mice showed that their fat cells retained markers of obesity even after losing weight. When reintroduced to a high-fat diet, these mice regained weight more quickly, and it was easier for them to become obese again.
While the researchers did not investigate how long this “cell memory” lasts, co-author Laura Hinte noted that fat cells are long-lived and can persist for up to ten years before being replaced by new ones.
Ferdinand von Meyenn, a professor of nutrition and metabolic epigenetics at ETH Zurich, emphasized the importance of preventing obesity in the first place. He explained, “It’s precisely because of this memory effect that it’s so important to avoid being overweight in the first place. Because that’s the simplest way to combat the yo-yo phenomenon.”
This groundbreaking study provides new insight into the biological factors behind weight loss struggles, offering hope for more effective strategies to combat the yo-yo effect in the future.
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Health
Obesity Linked to Poorer Outcomes in Childhood Cancer Patients, Study Finds
Children with obesity diagnosed with cancer face significantly worse health outcomes, including a heightened risk of relapse and death, according to a new Canadian study.
The research, published in the journal Cancer, analyzed data from over 11,000 cancer patients aged 2 to 19, of whom 10.5% were obese at diagnosis. The study examined various cancers, including leukemia, lymphoma, and other tumors, and found that obesity negatively impacted outcomes across the entire cohort.
Increased Risk of Relapse and Mortality
The findings revealed that obese children had a 16% higher risk of cancer relapse and a 29% increased risk of death within five years of diagnosis, even after accounting for factors such as age, sex, and ethnicity.
“Our study highlights the negative impact of obesity among all types of childhood cancers,” said Dr. Thai Hoa Tran, a pediatric hematologist and oncologist at the University Hospital Centre Sainte-Justine in Montreal, Canada, and one of the study’s authors.
Dr. Tran emphasized the need for strategies to address obesity’s impact on cancer outcomes in future clinical trials and highlighted the importance of combating the childhood obesity epidemic to prevent severe health consequences.
Acute Lymphoblastic Leukemia and Brain Tumors Most Affected
The study found the impact of obesity was particularly pronounced in children with acute lymphoblastic leukemia (ALL)—a cancer of the blood and bone marrow—and brain tumors. Researchers suggested that fat tissue may play an active role in tumor progression, metastasis, and resistance to treatment.
Previous research has indicated that adipose (fat) tissue cells can promote tumor development and hinder the effectiveness of therapies. Additionally, the study noted concerns about potential undertreatment and inappropriate dosing of chemotherapy in obese patients, which could further compromise outcomes.
Limitations and Calls for Improved Measures
The researchers acknowledged limitations in their study, including reliance on body mass index (BMI) to define obesity. They pointed out that BMI is an imprecise measure that does not fully capture body composition or nutritional status.
“BMI remains a crude and imperfect measure,” the authors wrote, echoing recent calls from experts to adopt more accurate diagnostic tools for obesity. Critics argue that BMI may lead to overdiagnosis or fail to reflect the nuanced impact of weight on health outcomes.
Implications and Urgency
The findings underscore the urgent need for interventions targeting childhood obesity and call for more precise research to better understand the interplay between obesity and cancer treatment. As childhood obesity rates continue to rise globally, addressing this epidemic could have far-reaching implications for improving survival rates and health outcomes for young cancer patients.
Health
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