Connect with us

Health

Study Links PFAS Exposure to Gut Microbiome Issues and Kidney Damage in Young Adults

Published

on

LOS ANGELES — New research suggests that exposure to per- and polyfluoroalkyl substances (PFAS), commonly referred to as “forever chemicals,” may contribute to disruptions in the gut microbiome that could, in turn, lead to kidney damage in young adults. This study adds to mounting concerns about the health impacts of these persistent chemicals.

PFAS, a group of synthetic chemicals, are widely used in a variety of everyday products, including food packaging, non-stick cookware, and water-resistant fabrics. Known as “forever chemicals” for their resilience, PFAS are nearly indestructible in nature and in the human body. As a result, they accumulate over time, becoming a near-universal presence in blood samples worldwide.

“Nearly everyone has PFAS in their blood, and these chemicals are linked to a range of negative health effects. But without interventions to remove PFAS from the body, there are no actionable recommendations to reduce exposure effects,” said Dr. Hailey Hampson, lead author and postdoctoral fellow at the Keck School of Medicine, in a statement.

Previous studies have associated PFAS exposure with a range of health issues, including liver damage, thyroid disorders, obesity, reproductive issues, and various cancers. This latest study highlights kidney disease as another potential consequence of exposure, focusing specifically on how changes in gut microbiome health may drive kidney damage in young adults.

In the study, researchers examined data from a cohort of 78 young adults, primarily Hispanic, aged 17 to 22, who are at higher risk of chronic kidney disease. Blood and stool samples collected from participants helped researchers measure PFAS levels, assess gut microbiome composition, and analyze metabolites circulating in their bodies. Four years later, the team reassessed the participants’ kidney function to evaluate long-term effects.

Findings revealed that participants with higher PFAS exposure experienced worse kidney function over time. The researchers linked this effect to changes in the gut microbiome, where PFAS exposure seemed to reduce anti-inflammatory metabolites and the bacteria responsible for producing them, while promoting inflammatory metabolites. The researchers found that these disruptions in gut health contributed to up to 50% of the decline in kidney function observed in the high-exposure group.

“These findings are an important piece of the puzzle about the many different health risks of PFAS,” said Dr. Jesse Goodrich, senior author of the study, which was published in Science of the Total Environment. “This information can help policymakers develop protections against exposure to these chemicals.”

While the sample size was limited, researchers emphasized the potential of their findings to guide future public health policies. As public awareness of PFAS contamination grows, the study offers early insights that may inform strategies to mitigate exposure and protect vulnerable populations.

The research team hopes that these insights will add to the growing body of evidence necessary for establishing regulations around PFAS, which remain ubiquitous in modern society despite their risks to human health.

Health

UK Cancer Care Disparities Highlighted in New Report

Published

on

By

A recent report from Cancer Research UK reveals stark disparities in cancer care across the United Kingdom, with cancer death rates nearly 60% higher in the most deprived areas compared to wealthier regions. The analysis estimates that about 28,400 cancer deaths each year—roughly three in every 20—are linked to socioeconomic inequality.

The study found that nearly one in 10 cancer diagnoses is associated with neighborhood deprivation, measured by factors such as income, education, and access to services. Lung cancer accounts for almost half of these deprivation-related deaths.

“These figures are shocking and unacceptable,” said Ian Walker, Cancer Research UK’s executive director of policy and information. He pointed to disparities in cancer risks, delayed diagnoses, and limited access to treatment as key drivers of the problem.

Two major risk factors—smoking and obesity—are more prevalent in deprived areas. Smoking rates are three times higher in these communities, and nearly 40% of residents are classified as obese. Limited access to green spaces and healthy food further contributes to these health challenges.

The report also highlighted differences in cancer diagnosis and treatment. People in deprived areas are more likely to be diagnosed at later stages, reducing their chances of survival. For certain cancers, they are less likely to receive chemotherapy, surgery, or innovative treatments. In England, many patients in these areas wait 104 days—over three months—or longer to begin treatment after an urgent referral for suspected cancer.

Walker emphasized the importance of early diagnosis, which can significantly improve survival rates. To address these issues, the charity is urging the UK government to increase funding for cancer and prevention services in high-need areas, including smoking cessation programs and nationwide lung cancer screenings.

“Beating cancer must mean beating it for everybody,” Walker said, underscoring the need to close the care gap and ensure equal access to life-saving treatments across all communities.

Continue Reading

Health

Georgia Woman Sues Fertility Clinic After Embryo Mix-Up Leads to Custody Loss

Published

on

By

A woman from Georgia, United States, is suing a fertility clinic after discovering she had given birth to another couple’s baby due to an embryo mix-up.

Krystena Murray, 38, became pregnant through in vitro fertilization (IVF) in 2023 and delivered a healthy baby boy in December. However, she immediately suspected something was wrong when she noticed the child was Black, while both she and her sperm donor are White. Subsequent DNA tests confirmed that the baby was not biologically related to her.

Murray claims that doctors at Coastal Fertility Specialists mistakenly implanted another couple’s embryo during the IVF procedure. Despite the mix-up, she initially decided to raise the child as her own. However, after notifying the clinic of the error, the staff informed the baby’s biological parents, who then sought custody through legal action.

Facing a court battle she felt she could not win, Murray relinquished custody when the child was five months old in May 2024. “I have never felt so violated, and the situation has left me emotionally and physically broken,” she said during a virtual press conference. “I spent my entire life wanting to be a mom. I loved, nurtured, and grew my child, and I would have done literally anything to keep him.”

Lawsuit and Clinic’s Response

On Tuesday, Murray filed a civil lawsuit against the fertility clinic, alleging negligence and seeking unspecified monetary damages for the emotional distress caused by the mix-up. Her attorney, Adam Wolf, emphasized the gravity of the mistake, stating that Murray had been “turned into an unwitting surrogate, against her will, for another couple.”

In a statement, Coastal Fertility Specialists acknowledged the error, describing it as “unprecedented” and apologizing to those affected. The clinic assured that it had implemented new safeguards to prevent similar incidents, adding, “This was an isolated event with no further patients affected. We are doing everything we can to make things right.”

Unanswered Questions and Rare Occurrence

Murray’s attorney noted that she still does not know what happened to her own embryos. While mistakes involving lost or damaged embryos are not uncommon, instances of transferring the wrong embryo are considered rare.

“Fertility clinics engage in vitally important work,” Wolf said. “With that amazing work comes a real responsibility. And when fertility clinics make mistakes like this, the consequences are life-altering.”

Reflecting on her experience, Murray expressed hope that her case would raise awareness among women considering IVF. “I considered the risks of bleeding, infection, and even death,” she said. “But never once did I think I might give birth to someone else’s child and then have them taken away from me.”

Continue Reading

Health

Tuscany Becomes First Italian Region to Approve Assisted Suicide Law

Published

on

By

Tuscany has become the first region in Italy to approve legislation regulating medically assisted suicide, marking a historic step in the country’s ongoing debate over end-of-life rights. However, the decision could face legal challenges from Italy’s far-right-led government, which remains largely opposed to euthanasia.

The right-to-die bill was passed by a vote of 27-13 in the region’s governing council, which is controlled by the centre-left. The new law establishes a formal process for patients seeking medically assisted suicide and ensures access to the procedure through the regional health system.

New Regulations for Assisted Suicide

Under the law, a medical and ethics commission will have 30 days to review an end-of-life request. If approved, the regional health services must provide the necessary medication and a doctor within 10 days.

The legislation also includes a conscientious objection clause, allowing medical professionals to opt out of participating in the procedure.

Regional Governor Eugenio Giani, a supporter of the bill, defended the move as a necessary step to clarify the legal framework surrounding assisted suicide in Italy.

“The law does nothing more than provide objective procedures and clarity,” Giani said before the vote. “I feel that we are giving a national message.”

Legal Uncertainty and Potential Challenges

Italy’s Constitutional Court ruled in 2019 that assisted suicide is legal for patients who suffer from an irreversible illness causing intolerable physical and psychological pain, provided they are capable of making a free and conscious decision.

However, the Italian Parliament has not passed national legislation to regulate the practice, leaving a legal gray area that Tuscany’s new law attempts to address.

The bill may face constitutional challenges from Prime Minister Giorgia Meloni’s government, which has taken a strong stance against euthanasia and assisted suicide. If the national government argues that Tuscany has overstepped its powers, the law could be blocked or overturned in court.

Italy Joins a Growing European Debate

While only a handful of European countries currently allow assisted suicide, the issue is gaining traction across the continent. Countries such as Switzerland, Belgium, and the Netherlands have long-established laws permitting euthanasia under strict conditions.

Elsewhere, including the United Kingdom, debates over assisted dying laws continue, reflecting shifting attitudes toward end-of-life choices.

For now, Tuscany’s law stands as a landmark decision, potentially paving the way for broader national discussions on the right to die in Italy.

Continue Reading

Trending