Health
Study Links PFAS Exposure to Gut Microbiome Issues and Kidney Damage in Young Adults
LOS ANGELES — New research suggests that exposure to per- and polyfluoroalkyl substances (PFAS), commonly referred to as “forever chemicals,” may contribute to disruptions in the gut microbiome that could, in turn, lead to kidney damage in young adults. This study adds to mounting concerns about the health impacts of these persistent chemicals.
PFAS, a group of synthetic chemicals, are widely used in a variety of everyday products, including food packaging, non-stick cookware, and water-resistant fabrics. Known as “forever chemicals” for their resilience, PFAS are nearly indestructible in nature and in the human body. As a result, they accumulate over time, becoming a near-universal presence in blood samples worldwide.
“Nearly everyone has PFAS in their blood, and these chemicals are linked to a range of negative health effects. But without interventions to remove PFAS from the body, there are no actionable recommendations to reduce exposure effects,” said Dr. Hailey Hampson, lead author and postdoctoral fellow at the Keck School of Medicine, in a statement.
Previous studies have associated PFAS exposure with a range of health issues, including liver damage, thyroid disorders, obesity, reproductive issues, and various cancers. This latest study highlights kidney disease as another potential consequence of exposure, focusing specifically on how changes in gut microbiome health may drive kidney damage in young adults.
In the study, researchers examined data from a cohort of 78 young adults, primarily Hispanic, aged 17 to 22, who are at higher risk of chronic kidney disease. Blood and stool samples collected from participants helped researchers measure PFAS levels, assess gut microbiome composition, and analyze metabolites circulating in their bodies. Four years later, the team reassessed the participants’ kidney function to evaluate long-term effects.
Findings revealed that participants with higher PFAS exposure experienced worse kidney function over time. The researchers linked this effect to changes in the gut microbiome, where PFAS exposure seemed to reduce anti-inflammatory metabolites and the bacteria responsible for producing them, while promoting inflammatory metabolites. The researchers found that these disruptions in gut health contributed to up to 50% of the decline in kidney function observed in the high-exposure group.
“These findings are an important piece of the puzzle about the many different health risks of PFAS,” said Dr. Jesse Goodrich, senior author of the study, which was published in Science of the Total Environment. “This information can help policymakers develop protections against exposure to these chemicals.”
While the sample size was limited, researchers emphasized the potential of their findings to guide future public health policies. As public awareness of PFAS contamination grows, the study offers early insights that may inform strategies to mitigate exposure and protect vulnerable populations.
The research team hopes that these insights will add to the growing body of evidence necessary for establishing regulations around PFAS, which remain ubiquitous in modern society despite their risks to human health.
Health
Scientists Warn of Health Risks from Fine Microplastics in Drinking Water
Health
Obesity Linked to Poorer Outcomes in Childhood Cancer Patients, Study Finds
Children with obesity diagnosed with cancer face significantly worse health outcomes, including a heightened risk of relapse and death, according to a new Canadian study.
The research, published in the journal Cancer, analyzed data from over 11,000 cancer patients aged 2 to 19, of whom 10.5% were obese at diagnosis. The study examined various cancers, including leukemia, lymphoma, and other tumors, and found that obesity negatively impacted outcomes across the entire cohort.
Increased Risk of Relapse and Mortality
The findings revealed that obese children had a 16% higher risk of cancer relapse and a 29% increased risk of death within five years of diagnosis, even after accounting for factors such as age, sex, and ethnicity.
“Our study highlights the negative impact of obesity among all types of childhood cancers,” said Dr. Thai Hoa Tran, a pediatric hematologist and oncologist at the University Hospital Centre Sainte-Justine in Montreal, Canada, and one of the study’s authors.
Dr. Tran emphasized the need for strategies to address obesity’s impact on cancer outcomes in future clinical trials and highlighted the importance of combating the childhood obesity epidemic to prevent severe health consequences.
Acute Lymphoblastic Leukemia and Brain Tumors Most Affected
The study found the impact of obesity was particularly pronounced in children with acute lymphoblastic leukemia (ALL)—a cancer of the blood and bone marrow—and brain tumors. Researchers suggested that fat tissue may play an active role in tumor progression, metastasis, and resistance to treatment.
Previous research has indicated that adipose (fat) tissue cells can promote tumor development and hinder the effectiveness of therapies. Additionally, the study noted concerns about potential undertreatment and inappropriate dosing of chemotherapy in obese patients, which could further compromise outcomes.
Limitations and Calls for Improved Measures
The researchers acknowledged limitations in their study, including reliance on body mass index (BMI) to define obesity. They pointed out that BMI is an imprecise measure that does not fully capture body composition or nutritional status.
“BMI remains a crude and imperfect measure,” the authors wrote, echoing recent calls from experts to adopt more accurate diagnostic tools for obesity. Critics argue that BMI may lead to overdiagnosis or fail to reflect the nuanced impact of weight on health outcomes.
Implications and Urgency
The findings underscore the urgent need for interventions targeting childhood obesity and call for more precise research to better understand the interplay between obesity and cancer treatment. As childhood obesity rates continue to rise globally, addressing this epidemic could have far-reaching implications for improving survival rates and health outcomes for young cancer patients.
Health
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