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Study Links PFAS Exposure to Gut Microbiome Issues and Kidney Damage in Young Adults

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LOS ANGELES — New research suggests that exposure to per- and polyfluoroalkyl substances (PFAS), commonly referred to as “forever chemicals,” may contribute to disruptions in the gut microbiome that could, in turn, lead to kidney damage in young adults. This study adds to mounting concerns about the health impacts of these persistent chemicals.

PFAS, a group of synthetic chemicals, are widely used in a variety of everyday products, including food packaging, non-stick cookware, and water-resistant fabrics. Known as “forever chemicals” for their resilience, PFAS are nearly indestructible in nature and in the human body. As a result, they accumulate over time, becoming a near-universal presence in blood samples worldwide.

“Nearly everyone has PFAS in their blood, and these chemicals are linked to a range of negative health effects. But without interventions to remove PFAS from the body, there are no actionable recommendations to reduce exposure effects,” said Dr. Hailey Hampson, lead author and postdoctoral fellow at the Keck School of Medicine, in a statement.

Previous studies have associated PFAS exposure with a range of health issues, including liver damage, thyroid disorders, obesity, reproductive issues, and various cancers. This latest study highlights kidney disease as another potential consequence of exposure, focusing specifically on how changes in gut microbiome health may drive kidney damage in young adults.

In the study, researchers examined data from a cohort of 78 young adults, primarily Hispanic, aged 17 to 22, who are at higher risk of chronic kidney disease. Blood and stool samples collected from participants helped researchers measure PFAS levels, assess gut microbiome composition, and analyze metabolites circulating in their bodies. Four years later, the team reassessed the participants’ kidney function to evaluate long-term effects.

Findings revealed that participants with higher PFAS exposure experienced worse kidney function over time. The researchers linked this effect to changes in the gut microbiome, where PFAS exposure seemed to reduce anti-inflammatory metabolites and the bacteria responsible for producing them, while promoting inflammatory metabolites. The researchers found that these disruptions in gut health contributed to up to 50% of the decline in kidney function observed in the high-exposure group.

“These findings are an important piece of the puzzle about the many different health risks of PFAS,” said Dr. Jesse Goodrich, senior author of the study, which was published in Science of the Total Environment. “This information can help policymakers develop protections against exposure to these chemicals.”

While the sample size was limited, researchers emphasized the potential of their findings to guide future public health policies. As public awareness of PFAS contamination grows, the study offers early insights that may inform strategies to mitigate exposure and protect vulnerable populations.

The research team hopes that these insights will add to the growing body of evidence necessary for establishing regulations around PFAS, which remain ubiquitous in modern society despite their risks to human health.

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German Consumer Group Warns Against Children’s Dietary Supplements

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A leading German consumer group has raised concerns about the safety and necessity of dietary supplements for children, after testing 18 common products and finding issues in 17 of them. The findings highlight the potential risks of excessive vitamin intake and misleading advertising by supplement manufacturers.

High Dosages and Questionable Claims

Berlin-based consumer organization Stiftung Warentest conducted an analysis of 18 widely available children’s dietary supplements. The group examined their ingredients, compared them with recommended nutrient intake levels, and evaluated the accuracy of their advertised benefits. The results were alarming—15 of the products contained dosages exceeding recommended levels for children, while five had vitamin A levels higher than the maximum safe limit for adults.

The group concluded that these supplements are “unnecessary at best and risky at worst.” Their findings align with the stance of the German Federal Institute for Risk Assessment (BfR), which states that food supplements are generally not needed for healthy individuals with balanced diets and cannot compensate for poor nutrition.

Growing Popularity Despite Risks

Dietary supplements, regulated as food products in the European Union, have gained widespread popularity in recent years. A 2022 survey across 14 EU countries found that 93% of adults had used supplements in the past year, primarily for perceived health benefits.

For children, supplements are often marketed as tools to enhance growth, cognitive function, or immune strength. However, Stiftung Warentest’s analysis suggests that some of these claims may be misleading.

“Manufacturers use enticing messages and suggestive images to make their products appealing to parents—sometimes using advertising claims that are illegal,” the group reported.

When Supplements Might Be Necessary

While Stiftung Warentest’s findings highlight significant concerns, some experts caution against completely dismissing dietary supplements. Dr. Berthold Koletzko, president of the European Academy of Paediatrics (EAP) and a paediatric gastroenterologist at Ludwig Maximilian University of Munich, acknowledges that most children do not require supplements but notes exceptions.

“There are young children and adolescents with suboptimal supplies of critical nutrients and even deficiencies,” Koletzko said, pointing to vitamin D, calcium, and omega-3 fatty acids as examples.

Certain dietary restrictions, such as vegetarian or gluten-free diets, may increase the need for supplementation. A 2017 study found that 3.4% of German children aged 6 to 17 were vegetarians, a number Koletzko believes has since increased. Additionally, children living in areas with limited sunlight may require vitamin D supplementation.

However, Koletzko warns that not all supplements are equal. Gummy vitamins, for instance, are often high in sugar and may encourage overconsumption due to their candy-like appearance. Excessive vitamin and mineral intake can lead to digestive issues, including stomach discomfort and loose stools.

Expert Advice is Essential

For parents concerned about their child’s nutrition, Koletzko emphasizes the importance of consulting a trusted healthcare professional.

“If you choose a supplement, it’s crucial to select the right one and get advice from your paediatrician,” he advised.

As the debate over dietary supplements continues, Stiftung Warentest’s findings serve as a reminder that parents should approach them with caution, prioritizing a balanced diet over unnecessary supplementation.

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US Tariffs on Pharmaceuticals Could Spark Global Trade Disruptions

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The pharmaceutical industry is bracing for potential upheaval as the United States considers imposing tariffs on drug imports, a move that could send shockwaves across global markets. President Donald Trump has signaled his intent to impose a 25% tariff on pharmaceuticals as part of a broader strategy to bring drug manufacturing back to the US.

Speaking from the Oval Office on Wednesday night, Trump confirmed his administration’s plans to target the pharmaceutical sector.

“We’re going to be doing tariffs on pharmaceuticals to bring our pharmaceuticals back,” he stated.

While the move aims to bolster domestic production, experts warn that the tariffs could lead to unintended consequences, including higher drug prices and supply chain disruptions that would impact both American and European companies. The US, a major importer of pharmaceuticals, heavily depends on European manufacturers for specialized medications. In 2023 alone, the US imported $170 billion (€157 billion) worth of pharmaceutical products, with $127 billion (€117 billion) coming from the EU.

European Markets at Risk

European pharmaceutical firms are particularly vulnerable to the proposed tariffs. Ireland, a key hub for American pharmaceutical companies, could face severe economic repercussions. In 2023, Ireland exported over €80 billion worth of pharmaceuticals to the US, accounting for more than half of its total exports. Major US firms like Pfizer, Johnson & Johnson, and Eli Lilly have significant operations in Ireland, and potential tariffs could lead to job losses and reduced investment.

Denmark’s pharmaceutical sector, especially Novo Nordisk, is also at risk. The company, a leader in diabetes and obesity treatments, generates over 50% of its revenue from the US market. Increased costs due to tariffs could impact American patients while also denting Denmark’s economic growth. The success of Novo Nordisk’s weight-loss drugs like Ozempic and Wegovy has been a major driver of Denmark’s GDP, contributing nearly half of its economic growth in 2023.

Impact on Other European Nations

Beyond Ireland and Denmark, other European pharmaceutical hubs would also feel the strain. Belgium, home to Pfizer’s major European production facilities, exported over $73 billion in pharmaceuticals in 2024, with a quarter of those exports going to the US. Germany’s pharmaceutical and biotech industries, including major players like Bayer and BioNTech, could also face setbacks. France, Italy, and Switzerland—key exporters of vaccines, generics, and high-value specialty drugs—would experience supply chain disruptions and financial strain.

EU Retaliation on the Horizon?

If the US proceeds with tariffs, the European Union may impose retaliatory measures targeting American pharmaceutical companies. The European Commission is reportedly exploring countermeasures, including higher export costs for US firms such as Pfizer, Merck, and Johnson & Johnson.

Additionally, the EU could prioritize domestic pharmaceutical companies in government contracts and revive stalled regulatory reforms, such as the General Pharmaceutical Legislation (GPL) reform, which aims to strengthen Europe’s pharmaceutical sovereignty. The recently proposed Critical Medicines Act could also serve as a framework to counterbalance US trade policies.

With negotiations ongoing, the global pharmaceutical industry is closely watching developments, as any trade war in this sector would have far-reaching consequences for businesses, patients, and healthcare systems on both sides of the Atlantic.

 

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Scientists Discover Drug That Makes Human Blood Lethal to Mosquitoes

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Researchers have identified a promising new method to combat mosquito-borne diseases such as malaria by making human blood toxic to mosquitoes. Their study, published in Science Translational Medicine, suggests that a drug commonly used for rare diseases could help eliminate mosquitoes when ingested through a blood meal.

Nitisinone: A Potential Weapon Against Malaria

The study focused on nitisinone, a medication prescribed for individuals with rare inherited metabolic disorders that affect amino acid breakdown. The drug functions by blocking a specific enzyme, preventing harmful byproducts from accumulating in the human body.

When mosquitoes feed on blood containing nitisinone, the drug disrupts their digestion, ultimately leading to their death. This discovery could pave the way for a novel mosquito control strategy.

“One way to stop the spread of diseases transmitted by insects is to make the blood of animals and humans toxic to these blood-feeding insects,” said Lee R. Haines, associate research professor at the University of Notre Dame and co-lead author of the study.

The findings suggest that nitisinone could serve as an effective and complementary tool in the fight against malaria, which remains a major global health concern.

A Growing Need for Mosquito Control Solutions

Currently, personal protective measures such as bed nets, insect repellents, and window screens help reduce mosquito bites. Another approach involves the use of ivermectin, a drug that kills parasites and is sometimes used to target mosquitoes. However, repeated use of ivermectin can lead to drug resistance and environmental concerns.

Nitisinone, on the other hand, demonstrated significant advantages over ivermectin.

“Nitisinone performance was fantastic,” said Álvaro Acosta Serrano, professor of biological sciences at Notre Dame and co-corresponding author of the study. “It has a much longer half-life in human blood than ivermectin, meaning its mosquito-killing activity lasts much longer. This is critical when applied in the field for safety and economic reasons.”

Crucially, the drug proved effective in eliminating mosquitoes across all age groups, including older mosquitoes, which are the most likely to transmit malaria. It also showed effectiveness against insecticide-resistant mosquitoes.

A New Approach to Mosquito-Borne Disease Prevention

Haines suggested that in the future, alternating between nitisinone and ivermectin could enhance mosquito control efforts.

“For example, nitisinone could be used in areas where ivermectin resistance persists or where the drug is already heavily used for livestock and humans,” he said.

Mosquito-borne diseases, including malaria, dengue, West Nile virus, chikungunya, and yellow fever, continue to pose a growing health threat. The European Centre for Disease Prevention and Control (ECDC) has warned that climate change is creating more favorable conditions for invasive mosquito species in Europe, even though malaria was eradicated from the continent decades ago.

This new discovery offers a promising avenue for combating the spread of these diseases, potentially reducing the global burden of mosquito-borne infections.

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