Health
Study Links Hormonal IUDs to Slightly Increased Breast Cancer Risk in Young Women
Copenhagen, Denmark — A recent study from the Danish Cancer Institute has found that hormone-releasing intrauterine devices (IUDs) may be associated with a slightly higher risk of breast cancer among young women. The large-scale study, published in the Journal of the American Medical Association (JAMA), has prompted health professionals to reconsider the risks and benefits of hormonal contraceptives.
The research examined health outcomes for around 79,000 women, aged 15 to 49, who used hormonal IUDs, such as the Mirena coil, compared to a similar group of women who did not use any form of hormonal birth control. The women were monitored over an average of 6.8 years. While the overall risk of developing breast cancer remained low, the study found that hormonal IUD users faced a slightly higher risk—about 14 additional cases of breast cancer per 10,000 women.
Hormonal IUDs, which release a progesterone-like hormone to prevent pregnancy, are commonly used across Europe, with about 8.1% of reproductive-age women relying on this form of contraception. Unlike copper IUDs, which do not involve hormones, devices like the Mirena coil work by slowly releasing hormones directly into the uterus. Many medical professionals had previously believed this localized hormone release posed a lower risk of breast cancer compared to oral contraceptive pills, which expose the body to higher levels of hormones.
However, the new findings challenge this assumption. “The results of this study are highly unexpected,” said Dr. Channa Jayasena, a reproductive endocrinologist at Imperial College London, who was not involved in the research.
The study has limitations, as it did not account for lifestyle factors like smoking, alcohol consumption, and obesity, all of which are known breast cancer risk factors. These unmeasured variables could influence the study’s results, but the data has nonetheless raised concerns.
Doctors and researchers are now advising that healthcare providers include potential breast cancer risks when discussing hormonal IUDs with patients. “My advice for women is that breast cancer risk caused by [IUDs] is not established but warrants a closer look,” Jayasena added.
This is not the first study to suggest a link between hormonal contraceptives and breast cancer. Last year, researchers at the University of Oxford found that progestogen-only contraceptives, regardless of their form, were associated with a slight increase in breast cancer risk. Experts suggest that the increased risk from IUDs may be similar to that posed by oral contraceptives.
Despite the findings, there remains broad medical consensus that the benefits of hormonal contraception outweigh the risks. Dr. Mangesh Thorat, a breast cancer surgeon and researcher at Queen Mary University of London, noted that certain types of IUDs have been shown to reduce the risks of cervical, endometrial, and ovarian cancers.
Thorat also highlighted that contraceptive risks change with age, suggesting that women nearing 40 should consider non-hormonal alternatives in consultation with their healthcare providers.
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Health
Obesity Linked to Poorer Outcomes in Childhood Cancer Patients, Study Finds
Children with obesity diagnosed with cancer face significantly worse health outcomes, including a heightened risk of relapse and death, according to a new Canadian study.
The research, published in the journal Cancer, analyzed data from over 11,000 cancer patients aged 2 to 19, of whom 10.5% were obese at diagnosis. The study examined various cancers, including leukemia, lymphoma, and other tumors, and found that obesity negatively impacted outcomes across the entire cohort.
Increased Risk of Relapse and Mortality
The findings revealed that obese children had a 16% higher risk of cancer relapse and a 29% increased risk of death within five years of diagnosis, even after accounting for factors such as age, sex, and ethnicity.
“Our study highlights the negative impact of obesity among all types of childhood cancers,” said Dr. Thai Hoa Tran, a pediatric hematologist and oncologist at the University Hospital Centre Sainte-Justine in Montreal, Canada, and one of the study’s authors.
Dr. Tran emphasized the need for strategies to address obesity’s impact on cancer outcomes in future clinical trials and highlighted the importance of combating the childhood obesity epidemic to prevent severe health consequences.
Acute Lymphoblastic Leukemia and Brain Tumors Most Affected
The study found the impact of obesity was particularly pronounced in children with acute lymphoblastic leukemia (ALL)—a cancer of the blood and bone marrow—and brain tumors. Researchers suggested that fat tissue may play an active role in tumor progression, metastasis, and resistance to treatment.
Previous research has indicated that adipose (fat) tissue cells can promote tumor development and hinder the effectiveness of therapies. Additionally, the study noted concerns about potential undertreatment and inappropriate dosing of chemotherapy in obese patients, which could further compromise outcomes.
Limitations and Calls for Improved Measures
The researchers acknowledged limitations in their study, including reliance on body mass index (BMI) to define obesity. They pointed out that BMI is an imprecise measure that does not fully capture body composition or nutritional status.
“BMI remains a crude and imperfect measure,” the authors wrote, echoing recent calls from experts to adopt more accurate diagnostic tools for obesity. Critics argue that BMI may lead to overdiagnosis or fail to reflect the nuanced impact of weight on health outcomes.
Implications and Urgency
The findings underscore the urgent need for interventions targeting childhood obesity and call for more precise research to better understand the interplay between obesity and cancer treatment. As childhood obesity rates continue to rise globally, addressing this epidemic could have far-reaching implications for improving survival rates and health outcomes for young cancer patients.
Health
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