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Second Round of Polio Vaccination Begins in Gaza Amid Conflict

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A second round of polio vaccinations commenced in Gaza on Monday, aiming to inoculate over half a million children as part of emergency efforts to control an outbreak first detected in July. The highly contagious virus was found in sewage samples and led to the paralysis of a 10-month-old child, marking the first polio case in the region in 25 years.

The initial phase of the vaccination campaign occurred in early September, with approximately 95% of eligible children receiving the first dose of the oral polio vaccine. The current round will provide the crucial second dose, necessary to halt the transmission of the virus. According to the World Health Organization (WHO), at least two doses are required to stop the spread, and a minimum of 90% vaccination coverage is essential to protect the population.

In addition to the polio vaccine, children between the ages of two and nine will receive Vitamin A to enhance overall immunity, the WHO reported.

Dr. Hamid Jafari, Director of Polio Eradication for WHO’s Eastern Mediterranean region, explained that polio outbreak responses typically involve multiple rounds of immunization to interrupt transmission at the community level. The Global Polio Eradication Initiative (GPEI) helps determine the number and scope of campaigns needed based on risk assessments, with this particular campaign targeting children under 10 in Gaza.

Vaccination Amid War and Shortages

The ongoing vaccination effort takes place under the shadow of the Israel-Hamas war, which erupted on October 7, 2023, when Hamas launched an attack in southern Israel. Israel’s subsequent military response, including airstrikes and a ground operation, has led to widespread devastation in Gaza, with more than 42,000 Palestinians killed, according to the territory’s health ministry.

The war has severely strained Gaza’s healthcare system, which WHO described as “virtually depleted.” The first round of vaccinations faced major logistical hurdles due to damaged infrastructure, a lack of supplies, and significant population displacement.

Despite these challenges, the first phase was considered a success, with mobile teams, outreach posts, and health facilities ensuring broad coverage. For the second round, similar strategies are being employed, with additional efforts to raise public awareness, including radio broadcasts and digital messaging.

In recent months, 1.6 million doses of the polio vaccine have been delivered to Gaza, along with essential equipment like refrigerators, freezers, and vaccine carriers.

Catherine Russell, Executive Director of UNICEF, emphasized the importance of “humanitarian pauses” in the conflict to ensure the vaccination campaign can continue without interruption, stressing that “without them, it is impossible to vaccinate the children.”

Global Polio Eradication Efforts

Polio is primarily transmitted through contact with the feces of an infected individual, often through contaminated water or food. While many people experience mild or no symptoms, the virus can cause paralysis and, in severe cases, death.

The ongoing global fight against polio has successfully reduced cases of wild poliovirus to just two countries, Afghanistan and Pakistan. However, outbreaks of vaccine-derived strains still occur in areas with low immunization rates. These strains, linked to the live virus in the oral vaccine, can be controlled with two to three rounds of immunization.

The novel version of the oral polio vaccine used in Gaza includes improvements designed to reduce the likelihood of the virus mutating and causing disease in under-vaccinated communities. Dr. Jafari stressed the importance of continued global cooperation, noting that “until we stop transmission of all polioviruses, children everywhere remain at risk.”

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Scientists Warn of Health Risks from Fine Microplastics in Drinking Water

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A new study has highlighted the presence of fine microplastics in drinking water, urging the European Union (EU) to revise its detection standards to include smaller particles that may pose a greater risk to human health.

Researchers in Toulouse, France, found that most microplastics in bottled and tap water samples measured less than 20 microns (μm), a size small enough to potentially pass from the human intestine into the bloodstream and organs. Current EU guidelines only require monitoring of particles between 20 μm and 5 mm, leaving these finer plastics largely undetected.

Majority of Microplastics Found Are Under 20 Microns

The study, published in PLOS Water, tested 10 bottled water brands and one tap water source using a new method capable of detecting microplastics smaller than 20 μm. Results showed that 98% of the microplastics detected were below this threshold, with 94% measuring less than 10 μm in diameter.

“The idea was to prove it’s possible to analyze very fine plastics and to show the European Union that setting the detection limit at 20 microns makes little sense,” said Oskar Hagelskjaer, CEO of Microplastic Solution and the study’s lead author.

The researchers found microplastic concentrations ranging from 19 to 1,154 particles per liter, with the tap water sample from Toulouse containing 413 particles per liter—higher than most bottled water samples.

Advanced Detection Methodology

The study employed enhanced instrumentation and rigorous quality control to prevent sample contamination, offering a more accurate assessment of microplastic prevalence.

Bethanie Carney Almroth, a professor of ecotoxicology at the University of Gothenburg, Sweden, called the methodology “quite strong,” noting the researchers’ careful consideration of potential contamination and measurement accuracy.

Microplastics in Bottled vs. Tap Water

While bottled water was packaged in polyethylene terephthalate (PET) bottles, PET was not the most prevalent plastic found in the samples. Researchers speculate that factors such as tap water filtration processes or river contamination may contribute more significantly to microplastic presence.

Groundwater-sourced drinking water, which undergoes natural soil filtration, showed significantly lower microplastic concentrations compared to treated surface water, the study found.

Health Concerns and Global Impact

The health implications of microplastic exposure remain uncertain, though their ubiquity raises concerns. “They’re finding them everywhere they look. We know we have them in our bodies,” Almroth said, adding that emerging evidence suggests potential health impacts.

Researchers described microplastic contamination as a “pervasive problem,” noting that no region on the planet remains unaffected. The findings call for immediate action to address the risks associated with microplastics in drinking water and the broader environment.

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Obesity Linked to Poorer Outcomes in Childhood Cancer Patients, Study Finds

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Children with obesity diagnosed with cancer face significantly worse health outcomes, including a heightened risk of relapse and death, according to a new Canadian study.

The research, published in the journal Cancer, analyzed data from over 11,000 cancer patients aged 2 to 19, of whom 10.5% were obese at diagnosis. The study examined various cancers, including leukemia, lymphoma, and other tumors, and found that obesity negatively impacted outcomes across the entire cohort.

Increased Risk of Relapse and Mortality

The findings revealed that obese children had a 16% higher risk of cancer relapse and a 29% increased risk of death within five years of diagnosis, even after accounting for factors such as age, sex, and ethnicity.

“Our study highlights the negative impact of obesity among all types of childhood cancers,” said Dr. Thai Hoa Tran, a pediatric hematologist and oncologist at the University Hospital Centre Sainte-Justine in Montreal, Canada, and one of the study’s authors.

Dr. Tran emphasized the need for strategies to address obesity’s impact on cancer outcomes in future clinical trials and highlighted the importance of combating the childhood obesity epidemic to prevent severe health consequences.

Acute Lymphoblastic Leukemia and Brain Tumors Most Affected

The study found the impact of obesity was particularly pronounced in children with acute lymphoblastic leukemia (ALL)—a cancer of the blood and bone marrow—and brain tumors. Researchers suggested that fat tissue may play an active role in tumor progression, metastasis, and resistance to treatment.

Previous research has indicated that adipose (fat) tissue cells can promote tumor development and hinder the effectiveness of therapies. Additionally, the study noted concerns about potential undertreatment and inappropriate dosing of chemotherapy in obese patients, which could further compromise outcomes.

Limitations and Calls for Improved Measures

The researchers acknowledged limitations in their study, including reliance on body mass index (BMI) to define obesity. They pointed out that BMI is an imprecise measure that does not fully capture body composition or nutritional status.

“BMI remains a crude and imperfect measure,” the authors wrote, echoing recent calls from experts to adopt more accurate diagnostic tools for obesity. Critics argue that BMI may lead to overdiagnosis or fail to reflect the nuanced impact of weight on health outcomes.

Implications and Urgency

The findings underscore the urgent need for interventions targeting childhood obesity and call for more precise research to better understand the interplay between obesity and cancer treatment. As childhood obesity rates continue to rise globally, addressing this epidemic could have far-reaching implications for improving survival rates and health outcomes for young cancer patients.

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Tanzania Reports Deadly Marburg Virus Outbreak, Eight Fatalities Confirmed

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Tanzania is grappling with an outbreak of the highly lethal Marburg virus, with eight fatalities confirmed so far, global health authorities reported.

The World Health Organization (WHO) identified the outbreak in the Biharamulo and Muleba districts of the Kagera region, an Eastern African transit hub. As of January 11, nine suspected cases have been reported, including healthcare workers. The Marburg virus, which is related to Ebola, has a case fatality rate of up to 89%, according to WHO officials.

Symptoms and Transmission

WHO said the suspected patients displayed classic symptoms of Marburg, such as high fever, headache, back pain, diarrhea, vomiting with blood, and severe physical weakness. In later stages, external hemorrhaging may occur.

The virus is transmitted through contact with bodily fluids of infected individuals or contaminated surfaces, putting healthcare workers and close contacts at heightened risk.

“There is an expectation of further cases as disease surveillance improves,” WHO Director-General Tedros Adhanom Ghebreyesus said in a social media update.

Containment Efforts Underway

Rapid response teams have been deployed to the affected areas to investigate and contain the outbreak. Authorities are tracing contacts of infected individuals, setting up treatment centers, and enhancing public awareness to prevent further spread.

However, officials caution that detection and isolation of cases have been delayed due to the Kagera region’s role as a transit hub, which may have facilitated the virus’s spread.

Neighbouring countries, including Rwanda, Uganda, Burundi, and the Democratic Republic of the Congo, have been urged to remain vigilant. “We recommend neighbouring countries be on alert and prepared to manage potential cases,” Tedros said.

No Approved Vaccine or Treatment

Marburg virus outbreaks are rare but severe, with fatality rates ranging from 24% to 88%. There is currently no authorized vaccine or treatment, although experimental options are being tested.

In 2023, a similar outbreak occurred in Tanzania’s Kagera region, resulting in nine cases and six deaths. Another outbreak in Rwanda last year sickened 66 people and caused 15 deaths before being declared over in December.

Zoonotic reservoirs, such as fruit bats, are believed to play a role in the virus’s transmission and remain endemic to the region, WHO noted.

Global Risk Assessment

While the risk of global spread is low, WHO considers the threat high for Tanzania and its regional neighbors. Health authorities are focusing on containing the outbreak swiftly to prevent a broader crisis.

“Marburg virus outbreaks underscore the need for robust surveillance systems and rapid response measures to protect public health,” the agency said in a statement.

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