Health
Second Round of Polio Vaccination Begins in Gaza Amid Conflict
A second round of polio vaccinations commenced in Gaza on Monday, aiming to inoculate over half a million children as part of emergency efforts to control an outbreak first detected in July. The highly contagious virus was found in sewage samples and led to the paralysis of a 10-month-old child, marking the first polio case in the region in 25 years.
The initial phase of the vaccination campaign occurred in early September, with approximately 95% of eligible children receiving the first dose of the oral polio vaccine. The current round will provide the crucial second dose, necessary to halt the transmission of the virus. According to the World Health Organization (WHO), at least two doses are required to stop the spread, and a minimum of 90% vaccination coverage is essential to protect the population.
In addition to the polio vaccine, children between the ages of two and nine will receive Vitamin A to enhance overall immunity, the WHO reported.
Dr. Hamid Jafari, Director of Polio Eradication for WHO’s Eastern Mediterranean region, explained that polio outbreak responses typically involve multiple rounds of immunization to interrupt transmission at the community level. The Global Polio Eradication Initiative (GPEI) helps determine the number and scope of campaigns needed based on risk assessments, with this particular campaign targeting children under 10 in Gaza.
Vaccination Amid War and Shortages
The ongoing vaccination effort takes place under the shadow of the Israel-Hamas war, which erupted on October 7, 2023, when Hamas launched an attack in southern Israel. Israel’s subsequent military response, including airstrikes and a ground operation, has led to widespread devastation in Gaza, with more than 42,000 Palestinians killed, according to the territory’s health ministry.
The war has severely strained Gaza’s healthcare system, which WHO described as “virtually depleted.” The first round of vaccinations faced major logistical hurdles due to damaged infrastructure, a lack of supplies, and significant population displacement.
Despite these challenges, the first phase was considered a success, with mobile teams, outreach posts, and health facilities ensuring broad coverage. For the second round, similar strategies are being employed, with additional efforts to raise public awareness, including radio broadcasts and digital messaging.
In recent months, 1.6 million doses of the polio vaccine have been delivered to Gaza, along with essential equipment like refrigerators, freezers, and vaccine carriers.
Catherine Russell, Executive Director of UNICEF, emphasized the importance of “humanitarian pauses” in the conflict to ensure the vaccination campaign can continue without interruption, stressing that “without them, it is impossible to vaccinate the children.”
Global Polio Eradication Efforts
Polio is primarily transmitted through contact with the feces of an infected individual, often through contaminated water or food. While many people experience mild or no symptoms, the virus can cause paralysis and, in severe cases, death.
The ongoing global fight against polio has successfully reduced cases of wild poliovirus to just two countries, Afghanistan and Pakistan. However, outbreaks of vaccine-derived strains still occur in areas with low immunization rates. These strains, linked to the live virus in the oral vaccine, can be controlled with two to three rounds of immunization.
The novel version of the oral polio vaccine used in Gaza includes improvements designed to reduce the likelihood of the virus mutating and causing disease in under-vaccinated communities. Dr. Jafari stressed the importance of continued global cooperation, noting that “until we stop transmission of all polioviruses, children everywhere remain at risk.”
Health
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Health
Obesity Linked to Poorer Outcomes in Childhood Cancer Patients, Study Finds
Children with obesity diagnosed with cancer face significantly worse health outcomes, including a heightened risk of relapse and death, according to a new Canadian study.
The research, published in the journal Cancer, analyzed data from over 11,000 cancer patients aged 2 to 19, of whom 10.5% were obese at diagnosis. The study examined various cancers, including leukemia, lymphoma, and other tumors, and found that obesity negatively impacted outcomes across the entire cohort.
Increased Risk of Relapse and Mortality
The findings revealed that obese children had a 16% higher risk of cancer relapse and a 29% increased risk of death within five years of diagnosis, even after accounting for factors such as age, sex, and ethnicity.
“Our study highlights the negative impact of obesity among all types of childhood cancers,” said Dr. Thai Hoa Tran, a pediatric hematologist and oncologist at the University Hospital Centre Sainte-Justine in Montreal, Canada, and one of the study’s authors.
Dr. Tran emphasized the need for strategies to address obesity’s impact on cancer outcomes in future clinical trials and highlighted the importance of combating the childhood obesity epidemic to prevent severe health consequences.
Acute Lymphoblastic Leukemia and Brain Tumors Most Affected
The study found the impact of obesity was particularly pronounced in children with acute lymphoblastic leukemia (ALL)—a cancer of the blood and bone marrow—and brain tumors. Researchers suggested that fat tissue may play an active role in tumor progression, metastasis, and resistance to treatment.
Previous research has indicated that adipose (fat) tissue cells can promote tumor development and hinder the effectiveness of therapies. Additionally, the study noted concerns about potential undertreatment and inappropriate dosing of chemotherapy in obese patients, which could further compromise outcomes.
Limitations and Calls for Improved Measures
The researchers acknowledged limitations in their study, including reliance on body mass index (BMI) to define obesity. They pointed out that BMI is an imprecise measure that does not fully capture body composition or nutritional status.
“BMI remains a crude and imperfect measure,” the authors wrote, echoing recent calls from experts to adopt more accurate diagnostic tools for obesity. Critics argue that BMI may lead to overdiagnosis or fail to reflect the nuanced impact of weight on health outcomes.
Implications and Urgency
The findings underscore the urgent need for interventions targeting childhood obesity and call for more precise research to better understand the interplay between obesity and cancer treatment. As childhood obesity rates continue to rise globally, addressing this epidemic could have far-reaching implications for improving survival rates and health outcomes for young cancer patients.
Health
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