Health
Raising Awareness of Haemochromatosis: The ‘Celtic Curse’ That Affects Millions
Haemochromatosis, a genetic condition that causes the body to store excessive amounts of iron, disproportionately affects people of Celtic heritage, including those from Ireland, Scotland, Wales, and Brittany. Despite its prevalence, awareness of the condition remains low, often leading to delayed diagnoses and increased health risks.
Iron is essential for producing haemoglobin, a protein in red blood cells responsible for oxygen transport. However, in individuals with haemochromatosis, iron accumulates in organs over time, potentially causing severe complications such as liver cirrhosis, liver cancer, and heart problems.
A Common but Underdiagnosed Condition
The condition often manifests through symptoms like fatigue, joint pain, and “brain fog,” which can appear as early as age 30 but are more common in men around 50 and women post-menopause. Diagnosis typically involves a blood test to detect mutations in the HFE gene, which regulates iron absorption. Individuals who inherit two faulty copies of the gene are at higher risk of developing the condition, while carriers with one faulty gene are less likely to experience symptoms.
Matt Skinner, 39, from Wales, shared his experience with haemochromatosis. “I had difficulty retaining information at work and felt constantly fatigued,” he said. Initially misdiagnosed with depression, Skinner’s condition was only identified after persistent medical consultations.
The Celtic Connection
Nicknamed the “Celtic Curse,” haemochromatosis is particularly prevalent among people of Irish descent. Studies by Haemochromatosis UK estimate that one in 10 people in Northern Ireland carries the gene mutation, compared to one in 113 in Scotland and one in 150 in England and Wales. Genetic traces of the condition have been found in human remains dating back to the Neolithic and Bronze Ages in Northern Ireland, underscoring its deep historical roots.
Despite its nickname, the reasons for the genetic mutation’s prominence in Celtic populations remain unclear.
Management and Treatment
While there is no cure for haemochromatosis, it can be effectively managed through early diagnosis and treatment. Options include venesection (similar to blood donation) to reduce iron levels and chelation therapy, which removes heavy metals from the blood. Early intervention minimizes the risk of organ damage and improves quality of life.
Edward Holland, 66, from England, has undergone 38 venesections since his diagnosis in 2023. “I feel as if I have more energy now,” he said, emphasizing the importance of awareness for earlier diagnosis and better outcomes.
Health organizations in Ireland and Scotland have ramped up efforts to encourage testing, but advocates like Skinner and Holland believe more public campaigns are needed. “If I’d been diagnosed earlier, I could be in maintenance now,” Skinner noted.
Haemochromatosis may be underdiagnosed, but with increased awareness and proactive testing, many more could benefit from early treatment and improved health outcomes.
Health
Global Obesity Rates Expected to Soar by 2050, Study Warns
A new study published in The Lancet projects that by 2050, nearly 60% of adults and 31% of children and young people worldwide will be overweight or obese, marking a sharp increase from previous decades. The research highlights a growing health crisis, with experts warning of serious consequences for global well-being.
A Worsening Trend
According to the study, 3.8 billion adults and 746 million young people are expected to be overweight or obese by mid-century. This marks a significant rise from 1990 figures when 731 million adults and 198 million young people were classified as overweight or obese. The findings show that each new generation is gaining weight earlier and faster than before.
For example, in high-income countries, 7% of men born in the 1960s were obese by the age of 25, but this percentage increased to 16% for men born in the 1990s and is expected to reach 25% for those born in 2015. This trend is fueling an epidemic linked to type 2 diabetes, high blood pressure, heart disease, and certain cancers.
Emmanuela Gakidou, one of the study’s authors, called the obesity crisis a “monumental societal failure.”
Global Hotspots for Obesity
The study identified several countries as obesity hotspots. In 2021, over half of the world’s overweight or obese adults were concentrated in just eight countries:
- China (402 million)
- India (180 million)
- United States (172 million)
- Brazil (88 million)
- Russia (71 million)
- Mexico (58 million)
- Indonesia (52 million)
- Egypt (41 million)
Future growth in obesity rates is expected to be driven by population increases in Asia and sub-Saharan Africa. Among high-income nations, the United States, Chile, and Argentina are projected to have the highest obesity rates. In Europe, Greece is forecasted to have the highest levels of obesity by 2050, affecting 48% of women and 41% of men.
Impact on Healthcare Systems
As obesity rates climb, so do associated health risks. The study estimates that by 2050, one in four obese adults worldwide will be over 65, adding further strain on global healthcare systems. The effects are already being felt in countries like the U.S., Australia, and parts of Europe, where obesity-related health complications are lowering life expectancy and quality of life.
Despite these alarming trends, research suggests that only 7% of countries worldwide have healthcare systems prepared to tackle the rising obesity-related health burdens. Experts warn that without intervention, obesity will continue to drive millions of premature deaths annually from conditions like diabetes, heart disease, cancer, and stroke.
Rising Obesity Rates Among Young People
The research also paints a troubling picture for younger generations. While most young people in 2050 are expected to be overweight rather than obese, childhood and adolescent obesity rates are set to increase by 121%.
Obesity is expected to rise sharply in North Africa, the Middle East, Latin America, and the Caribbean, as well as in large nations such as the U.S. and China. Among high-income nations, Chile is forecasted to have the highest childhood obesity rates, while the U.S. will lead in obesity among young adults (ages 15-24). In Europe, Greece and San Marino will have the highest rates among boys and girls, respectively.
Dr. Jessica Kerr, one of the study’s authors, emphasized that interventions are still possible, saying, “If we act now, we can prevent a complete transition to global obesity for children and adolescents.”
Calls for Policy Changes
Experts argue that addressing the crisis requires more than just medical treatments. The study measured obesity using body mass index (BMI), a widely used metric, but one that some researchers say should be replaced with more precise health indicators.
Meanwhile, new weight-loss drugs, such as GLP-1 receptor agonists, have been hailed as potential game-changers, but experts caution that medications alone cannot stop the obesity epidemic.
Johanna Ralston, CEO of the World Obesity Federation, warned that tackling obesity requires comprehensive policy changes. Strategies such as food labeling, taxation on unhealthy foods, and better urban planning to encourage physical activity are crucial to combating the crisis.
“We can’t just treat our way out of it. We need to change the way we approach food and exercise as a society,” Ralston said.
The findings underscore the urgent need for a global, multi-pronged strategy to address the obesity epidemic before it becomes an even greater public health catastrophe.
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