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Pig Organ Transplants Show Promise Amid High Demand and Challenges

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Despite initial setbacks, the use of gene-edited pig organs in transplants is gaining momentum as U.S. researchers work to address a dire shortage of donor organs. Two companies are preparing for the first clinical trials of xenotransplantation in 2025, aiming to use pig kidneys and hearts to save human lives.

A Glimmer of Hope

Interest in pig organ transplants surged following recent experiments, including a successful case at NYU Langone Health in November, where a woman fared well after receiving a pig kidney. While none of the first four patients who received pig organs survived beyond two months, the experiments have provided valuable insights.

Dr. Bartley Griffith, a transplant surgeon at the University of Maryland, emphasized the importance of perseverance, saying, “We have to have the courage to continue.”

High Demand Among Potential Patients

For patients like Alex Berrios of Louisville, Kentucky, the possibility of receiving a pig kidney offers hope. Berrios, who has been on dialysis since 2020 after his first kidney transplant failed, is “highly sensitized,” meaning his immune system would reject another human kidney.

“I think it’s worth the shot,” said Berrios, who has already expressed interest in participating in research trials.

Others, like Carl McNew from Palm Springs, California, are also eager to volunteer. McNew, who previously donated a kidney to his husband, now faces kidney failure himself. He views the opportunity as a chance to contribute to groundbreaking medical advancements.

Rigorous Testing and Research

To ensure safety and effectiveness, the U.S. Food and Drug Administration (FDA) requires pig organs to undergo extensive testing in primates before being used in human trials. While researchers have extended the survival of pig organ recipients in baboons for over a year, the ultimate goal is to replicate these results in humans.

Experiments so far have been limited to emergency “compassionate use” transplants for patients with no other options. Despite complications from other diseases, these cases demonstrated that pig organs could function for a short period and highlighted areas for improvement, such as detecting hidden pig viruses.

Challenges and Ethical Considerations

The upcoming clinical trials aim to test genetically modified pig organs that are more human-like. Researchers face the challenge of selecting participants who are sick enough to need the transplant but not too ill to survive the procedure.

Dr. Silke Niederhaus, a transplant expert at the University of Maryland, advises patients to carefully consider their options. “If they’re older and dialysis is starting to fail, maybe it’s worth taking the risk,” she said.

Future of Xenotransplantation

The field has much to prove, with researchers under pressure to show that pig organs can sustain life for significantly longer periods. As advancements continue, patients like Berrios and McNew represent the growing hope that xenotransplantation could eventually revolutionize organ donation and save countless lives.

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Italy Allocates €4.2 Million Fund to Combat Obesity, Sparking Debate on Impact

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Italy is on the verge of creating a €4.2 million public fund aimed at addressing obesity, a health issue affecting approximately six million Italians. While advocates have hailed the move as a significant step forward, critics argue that the funding falls short of addressing the scope of the problem.

The fund, included in Italy’s 2025 budget law, is set to be approved by parliament. Managed by the health ministry, it will be distributed over three years to support obesity-related initiatives. This marks a continuation of Italy’s recent efforts to recognize obesity as a chronic disease, a status it gained in 2019.

Growing Obesity Concerns

Although Italy’s obesity rate of 11.4% is below the European Union average of 16%, rising rates among children and teenagers have raised alarms. A 2023 European Commission report highlighted high levels of physical inactivity among Italian youth, warning of potential long-term public health challenges.

Dr. Paolo Sbraccia, head of the internal medicine unit and obesity center at the University of Rome Tor Vergata, called the fund a “real breakthrough” in paving the way for future resources. However, he acknowledged that obesity remains largely overlooked in Italy’s healthcare system despite being included in the country’s chronic disease plan this year.

Symbolic or Substantial?

Not everyone is convinced of the fund’s potential impact. Francesco Paolucci, a professor of health economics and policy at the University of Bologna, described the fund as a “drop in the ocean.” He argued that it is more of a symbolic gesture than a comprehensive solution, adding, “It’s saying that something needs to be done, but it’s not enough.”

Roberto Pella, a lawmaker from the Forza Italia party and advocate for combating chronic diseases, introduced the amendment to create the fund. Pella has promised further legislation by 2025 to ensure broader access to nutritional, pharmaceutical, and surgical treatments for obesity.

Debate Over Medication Costs

The fund has raised questions about its use, particularly regarding expensive weight-loss drugs like Ozempic and Wegovy. While these medications are approved in Italy, they are not covered by the national health service due to cost concerns. Spending on semaglutide, the active ingredient in both drugs, surged by over 50% in 2023, highlighting the financial burden on the healthcare system.

Sbraccia argued that such drugs should be reserved for patients with severe obesity or those at high risk of complications, given the high prevalence of the condition.

A Call for Systemic Reform

Critics like Paolucci contend that Italy’s healthcare system requires broader reform to tackle chronic conditions effectively. Without improved access to primary care, he warned, obesity and other health issues would continue to strain the country’s hospital system.

“Obesity is both a problem in itself and a risk factor,” Paolucci said. “If we don’t address it comprehensively, it will exacerbate pressures on an already struggling healthcare system.”

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Experts Debate the Effectiveness of Standing Desks in Combating Sedentary Lifestyles

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Standing desks have gained popularity as a solution for office workers aiming to counter the negative health impacts of prolonged sitting. While marketed as tools for weight loss, improved blood sugar regulation, and reduced back pain, experts remain divided on their actual benefits.

Standing vs. Sitting: The Science

Kévin Desbrosses, a researcher at France’s National Research and Safety Institute (INRS), highlights some advantages of standing over sitting. “Sedentary behavior is defined as sitting or lying down for extended periods with very low energy expenditure,” he told Euronews Health. Desbrosses explained that standing promotes better blood flow and expends more energy, though prolonged standing can also have drawbacks.

A study led by Matthew Ahmadi of the University of Sydney revealed mixed results. “Standing was better than sitting overall, but it wasn’t associated with a significantly lower risk of heart disease,” Ahmadi said. However, extended periods of standing were linked to circulatory problems such as varicose veins and deep vein thrombosis due to blood pooling in the legs.

Another recent study from the University of Turku in Finland found that prolonged standing at work could lead to higher blood pressure, raising further questions about its suitability as a long-term solution.

Movement: The Key to Better Health

Experts agree that incorporating regular movement into daily routines is more effective than simply alternating between sitting and standing. Desbrosses advocates for frequent posture changes, ideally every 30 minutes, using adjustable-height desks as a helpful tool.

Prolonged sitting, research shows, is linked to a range of health problems, including diabetes, cardiovascular disease, certain cancers, and even depression. Alicia Fillon from the French National Observatory on Physical Activity and Sedentariness explained that sitting too long affects the body’s ability to regulate arterial dilation, leading to oxidative stress and inflammation.

Fillon also noted the cognitive risks of excessive sitting. Studies indicate that it increases the risk of dementia over time, even in individuals who exercise regularly.

Impact on Productivity

A 2019 review of scientific literature found no negative effects on productivity when individuals alternated between sitting and standing. This suggests that integrating movement into the workday doesn’t compromise performance.

The Bottom Line

While standing desks offer some benefits, experts emphasize that they are not a comprehensive solution. Regular movement, including brief walking or stretching breaks, remains the most effective way to combat the health risks associated with a sedentary lifestyle. As research continues, balancing sitting, standing, and movement seems to be the healthiest approach for office workers.

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Study Links Navigational Tasks in Driving Professions to Lower Alzheimer’s Death Rates

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Taxi and ambulance drivers exhibit lower Alzheimer’s-related death rates compared to hundreds of other professions, potentially suggesting a connection between memory-intensive jobs and reduced dementia risk, according to a new study published in The BMJ.

Conducted by researchers from Harvard Medical School, the study analyzed data from nearly 9 million U.S. deaths between 2020 and 2022 across 443 occupations. It found that just 1.03% of deaths among taxi drivers and chauffeurs and 0.91% among ambulance drivers were linked to Alzheimer’s disease. This contrasts sharply with the general population, where Alzheimer’s accounted for 1.69% of deaths.

Navigational Demands and Brain Function

The study highlights the demanding navigational tasks these drivers perform, which require frequent use of the hippocampus—a brain region critical for spatial memory and navigation. The hippocampus is also among the first areas affected by Alzheimer’s, the most common form of dementia.

Dr. Anupam B. Jena, senior author of the study and a professor at Harvard Medical School, noted that long-term navigational processing, as seen in taxi drivers, may have protective effects on the brain. However, he cautioned against assuming that simply avoiding GPS or increasing navigation tasks in daily life could replicate the benefits.

“The use of that part of the brain in taxi drivers happens over decades and in an intense, minute-to-minute manner,” Jena told Euronews Health.

Cautious Interpretations

While the findings raise intriguing possibilities, the study authors stressed that they do not prove causation. It’s possible that individuals with strong natural navigational skills are more likely to choose these professions, making them less prone to Alzheimer’s irrespective of their work.

Angela Bradshaw, director for research at Alzheimer Europe, echoed the caution, pointing out that cognitive stimulation from spatial tasks could contribute to lower dementia risk. She referenced other studies, including a 2023 Australian study, which found that mentally engaging activities like puzzles and writing were associated with reduced dementia risk over a decade.

Study Limitations

Despite its insights, the study has several limitations. The average age of death for taxi and ambulance drivers in the study was between 64 and 67, younger than the typical onset of Alzheimer’s, which usually occurs after age 65. Additionally, the sample included few women, who statistically face higher Alzheimer’s risks.

The study also lacked genetic data or brain scans, leaving questions about whether job-related brain changes occur over time.

Tara Spires-Jones, president of the British Neuroscience Association, called for more research to explore protective strategies against Alzheimer’s.

Growing Need for Dementia Research

Alzheimer Europe estimates that nearly 8 million people in the EU have dementia, with Alzheimer’s accounting for over half of these cases. As dementia prevalence rises globally, studies like this underscore the need to better understand the disease and identify preventive measures.

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