Business
Novo Nordisk Reports Promising Trial Results for Next-Gen Obesity Drug, Shares Surge
Novo Nordisk, Europe’s largest pharmaceutical company, announced encouraging trial results for its next-generation obesity drug, amycretin, propelling its shares to a 7.13% gain in Copenhagen on Friday.
Key Trial Findings
The trial revealed that patients on the highest dose of 20 milligrams of amycretin achieved an estimated weight loss of 22% over 36 weeks. This result closely rivals Eli Lilly’s obesity drug Zepbound, which achieved a 22.5% weight loss over 72 weeks, and Lilly’s next-generation treatment, retatrutide, which reported a 24.4% weight reduction over 48 weeks.
Novo Nordisk’s amycretin is seen as a major contender in the competitive weight-loss drug market, particularly as the patent for its blockbuster treatment Wegovy is set to expire in the early 2030s.
Advancements in Treatment
Amycretin represents a significant step forward in weight-loss therapies, combining the effects of two hormones, glucagon-like peptide-1 (GLP-1) and amylin. This dual action enhances satiety and regulates blood sugar levels, providing a more comprehensive approach compared to Wegovy, which focuses solely on GLP-1.
The trials tested once-weekly injections of amycretin in 125 participants, showing:
- 9.7% weight loss with a 1.25-milligram dose over 20 weeks.
- 16.2% weight loss with 5 milligrams over 28 weeks.
- 22.1% weight loss with 20 milligrams over 36 weeks.
Most side effects were gastrointestinal and mild to moderate in severity. Novo Nordisk plans to advance amycretin into further clinical trials for adults with obesity or overweight conditions.
Market Impact and Competition
Following the announcement, Novo Nordisk’s shares saw a significant surge, recovering from a 14% decline over the past year. Meanwhile, Eli Lilly, a key competitor, experienced a brief 1.2% dip in U.S. markets before closing 2.45% higher.
Eli Lilly is also making strides with its oral weight-loss pill, orforglipron, which demonstrated a 14.7% weight loss over 36 weeks in a mid-stage trial. Oral treatments are gaining traction due to their convenience and cost-effectiveness compared to injectable therapies.
Novo Nordisk is developing an oral version of amycretin, showing a 13.1% weight reduction in trials, although this formulation presented more side effects. Its oral semaglutide trials reported a 15% weight loss over 68 weeks.
Outlook
With amycretin’s promising results and Wegovy’s robust sales, which rose 79% year-on-year in Q3, Novo Nordisk is poised for growth in the weight-loss drug market. The company’s fourth-quarter and full-year earnings are set to be released on February 5, offering further insights into its performance amid intensifying competition.
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Ukrainian Women Lead Europe in Entrepreneurial Ambitions, New Study Finds
A new study commissioned by Mastercard reveals that Ukrainian women have the highest entrepreneurial aspirations in Europe, despite facing war and economic uncertainty. According to the report, 66% of Ukrainian women plan to start their own businesses, a figure that rises to 83% among Gen Z women.
Women in Ukraine Defy Challenges to Pursue Entrepreneurship
The study highlights how Ukrainian women are turning to business ownership as a means of financial stability and social impact. Many cite lack of funds (76%), lack of experience (47%), and lack of confidence (38%) as barriers, yet their resilience remains strong.
Among the most popular industries for female entrepreneurs in Ukraine are online sales (22%), education (17%), agriculture (15%), and food and drink (15%).
Mastercard emphasized the role of female entrepreneurs in economic resilience and recovery, citing stories like Inna Bozhko, a businesswoman from Kharkiv. Bozhko, a mother of a child with cerebral palsy, opened Barbershop Inclusive, which includes a soundproofed area for children with sensory sensitivities. She received support from the Mastercard Center for Inclusive Growth, demonstrating how financial backing and mentorship can help women succeed.
Portugal, Poland, and Greece Lead Female Entrepreneurship in the EU
Within the European Union, Portugal, Poland, and Greece have the highest number of women aspiring to start businesses.
- Portugal: 62% of women have considered starting a business, with 56% actively planning to do so.
- Poland: 47% of women have shown interest, with 36% making concrete plans.
- Greece: 46% are considering entrepreneurship, with the same percentage moving forward with their plans.
Portuguese women stand out not only for their business ambitions but also for their financial literacy. The study found that Portuguese women are twice as confident in handling finances compared to the average European woman.
Gen Z Women Are Driving Change
The study also highlights the influence of Gen Z women, who are increasingly motivated by a desire to make a positive impact.
- 19% of Gen Z women in Europe say they want to start businesses to “do something good for the world,” compared to 13% of Millennials and 14% of Gen X.
- Their preferred industries include education, childcare, and cosmetics, with beauty entrepreneurship being the most popular sector (26% vs. 10% European average).
Challenges and Solutions for Female Entrepreneurs
Despite their ambition, women across Europe continue to face significant barriers when starting businesses. The study identified three major concerns:
- Fear of failure (31%)
- Lack of financial resources (29%)
- Lack of experience (28%)
In addition, many women struggle with balancing family responsibilities, which can limit their ability to pursue business ventures.
However, Mastercard and Amazon Web Services (AWS) believe that digital technology can help bridge the gap. From AI-powered automation to e-commerce platforms, technological advancements are making it easier for women to start, manage, and scale their businesses.
Empowering the Next Generation of Female Entrepreneurs
AWS Vice President Tanuja Randery, a founder of the PowerWomen Network, emphasized the need for sponsorship, mentorship, and financial support for women entrepreneurs.
“To accelerate female entrepreneurship and enable the next unicorns in Europe, we need to ensure women have access to the right sponsors, networks, and funding,” Randery told Euronews Business.
She offered three key pieces of advice for aspiring female entrepreneurs:
- Have a plan – “If you don’t know where you’re going, any road will take you there.”
- Find sponsors, not just mentors – “Women are often over-mentored but under-sponsored.”
- Take risks – “Move across industries and geographies, embrace feedback, and stay true to yourself.”
As entrepreneurial ambition among women grows across Europe, particularly in Ukraine, greater financial access, mentorship, and digital tools could help unlock the full potential of female-led businesses.
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