Health
Fresh Embryos May Boost IVF Success for Women with Lower Fertility Odds, Study Finds
Women struggling with infertility and facing lower odds of success with in vitro fertilization (IVF) may have better chances of conceiving with fresh embryos rather than frozen ones, according to a new study from China.
The research, published in the BMJ, examined 838 women in their 30s who had a limited number of healthy eggs. It found that 40.1% of women who received fresh embryo transfers gave birth, compared to 31.5% of those who received frozen embryo transfers. Additionally, women who had fresh embryo transfers were more likely to get pregnant and less likely to suffer a miscarriage.
Rethinking the ‘Freeze-All’ Strategy
IVF, the most common fertility treatment worldwide, involves removing a woman’s eggs, fertilizing them with sperm in a lab, and transferring the resulting embryos back into the uterus. Many fertility doctors follow a “freeze-all” approach, where multiple embryos are collected and frozen for later use. This method is widely used to reduce potential risks associated with hormone stimulation and to allow the woman’s body to recover before implantation.
However, the new findings suggest that this strategy may not be the best option for women who already have lower chances of success. Factors such as age, underlying health conditions, low egg count, and poor egg quality all play a role in IVF outcomes, and fresh embryo transfers may improve results for these patients.
“A Crucial Clinical Question”
Dr. Daimin Wei, the study’s lead author and a professor at Shandong University’s Reproductive Medical Center, emphasized the significance of the findings.
“How to optimally use the ‘precious’ embryos to increase the chance of live birth in these patients is an important clinical question,” Wei told Euronews Health.
The study also found no difference in birth weight, neonatal health issues, or pregnancy complications between babies born from fresh or frozen embryos, further supporting the case for fresh transfers in specific patient groups.
Limitations and Future Research
This research is among the first to examine whether fresh or frozen embryos impact success rates in women with a poor prognosis. Most previous studies focused on women with normal or high chances of success, where frozen embryo transfers were found to be equally effective or even preferred.
The researchers acknowledged some limitations in their study, including differences in the number of embryos transferred and the developmental stage at which they were implanted. These factors could have contributed to the varying success rates between fresh and frozen transfers.
Additionally, male fertility and sperm quality were noted as contributing factors in about 17% of cases, reinforcing the need for a holistic approach to fertility treatments.
A More Personalized Approach to IVF
While fresh embryo transfers may not be the best option for all IVF patients, the study suggests that fertility doctors should consider individual patient characteristics when planning treatments.
“For clinicians, it is suggested to individually choose the embryo transfer strategy based on ovarian response and patient characteristics to optimize IVF outcomes,” Wei concluded.
The findings could help refine IVF protocols, offering more personalized fertility treatments and potentially improving success rates for those facing the greatest challenges in conceiving.
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Early-Onset Cancer Rates Rising in U.S., But Deaths Mostly Stable, Study Finds

A new U.S. government study has revealed that while cancer diagnoses among people under 50 are on the rise, the overall death rates for most types of cancer in this age group remain stable.
Published Thursday in the journal Cancer Discovery, the study is one of the most comprehensive assessments to date of early-onset cancers, analyzing data from more than two million cases diagnosed in Americans aged 15 to 49 between 2010 and 2019.
The findings show that 14 out of 33 cancer types had increasing incidence rates in at least one younger age group. The most significant increases were seen in breast, colorectal, kidney, and uterine cancers. Women accounted for about 63 percent of the early-onset cases.
“This pattern generally reflects something profound going on,” said Tim Rebbeck of the Dana-Farber Cancer Institute, who was not involved in the study. “We need to fund research that will help us understand why this is happening.”
The study found that, compared to 2010 data, there were 4,800 more breast cancer cases, 2,000 additional colorectal cancers, 1,800 more kidney cancers, and 1,200 extra uterine cancers by 2019.
Despite the rising numbers, researchers emphasized a key reassurance: death rates for most of these cancers are not increasing. However, exceptions were noted—colorectal, uterine, and testicular cancers saw slight rises in mortality among younger adults.
The causes behind the rise in early-onset cancers are not fully understood. The study’s datasets do not include information on potential risk factors such as obesity, lifestyle, or access to healthcare. However, researchers, including lead author Dr. Meredith Shiels of the National Cancer Institute, highlighted obesity as a possible driver.
“Several of these cancer types are known to be associated with excess body weight,” said Dr. Shiels. She also pointed to advances in detection and changing screening practices as possible contributors to earlier diagnoses.
Breast cancer trends may also be influenced by shifting reproductive patterns, such as women having children later in life, which has been associated with increased cancer risk due to fewer years of pregnancy and breastfeeding—factors known to lower risk.
Not all cancer types followed the upward trend. Rates of more than a dozen cancers, including lung and prostate cancer, are decreasing among younger people. Researchers attribute the lung cancer decline to reduced smoking rates, while updated PSA screening guidelines are likely behind the drop in prostate cancer diagnoses.
Experts plan to convene later this year to further investigate the growing early-onset cancer burden and explore targeted prevention strategies.
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