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Fresh Embryos May Boost IVF Success for Women with Lower Fertility Odds, Study Finds

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Women struggling with infertility and facing lower odds of success with in vitro fertilization (IVF) may have better chances of conceiving with fresh embryos rather than frozen ones, according to a new study from China.

The research, published in the BMJ, examined 838 women in their 30s who had a limited number of healthy eggs. It found that 40.1% of women who received fresh embryo transfers gave birth, compared to 31.5% of those who received frozen embryo transfers. Additionally, women who had fresh embryo transfers were more likely to get pregnant and less likely to suffer a miscarriage.

Rethinking the ‘Freeze-All’ Strategy

IVF, the most common fertility treatment worldwide, involves removing a woman’s eggs, fertilizing them with sperm in a lab, and transferring the resulting embryos back into the uterus. Many fertility doctors follow a “freeze-all” approach, where multiple embryos are collected and frozen for later use. This method is widely used to reduce potential risks associated with hormone stimulation and to allow the woman’s body to recover before implantation.

However, the new findings suggest that this strategy may not be the best option for women who already have lower chances of success. Factors such as age, underlying health conditions, low egg count, and poor egg quality all play a role in IVF outcomes, and fresh embryo transfers may improve results for these patients.

“A Crucial Clinical Question”

Dr. Daimin Wei, the study’s lead author and a professor at Shandong University’s Reproductive Medical Center, emphasized the significance of the findings.

“How to optimally use the ‘precious’ embryos to increase the chance of live birth in these patients is an important clinical question,” Wei told Euronews Health.

The study also found no difference in birth weight, neonatal health issues, or pregnancy complications between babies born from fresh or frozen embryos, further supporting the case for fresh transfers in specific patient groups.

Limitations and Future Research

This research is among the first to examine whether fresh or frozen embryos impact success rates in women with a poor prognosis. Most previous studies focused on women with normal or high chances of success, where frozen embryo transfers were found to be equally effective or even preferred.

The researchers acknowledged some limitations in their study, including differences in the number of embryos transferred and the developmental stage at which they were implanted. These factors could have contributed to the varying success rates between fresh and frozen transfers.

Additionally, male fertility and sperm quality were noted as contributing factors in about 17% of cases, reinforcing the need for a holistic approach to fertility treatments.

A More Personalized Approach to IVF

While fresh embryo transfers may not be the best option for all IVF patients, the study suggests that fertility doctors should consider individual patient characteristics when planning treatments.

“For clinicians, it is suggested to individually choose the embryo transfer strategy based on ovarian response and patient characteristics to optimize IVF outcomes,” Wei concluded.

The findings could help refine IVF protocols, offering more personalized fertility treatments and potentially improving success rates for those facing the greatest challenges in conceiving.

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Ultra-Processed Foods Linked to Heart Disease, Parkinson’s, and Early Death, Study Finds

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A new study has reinforced growing concerns about ultra-processed foods (UPFs), linking them to an increased risk of heart disease, high blood pressure, stroke, and even Parkinson’s disease—marking the first time a connection between UPFs and the neurodegenerative disorder has been identified.

The research, published by the World Health Organization’s (WHO) cancer research agency in The Lancet Regional Health – Europe, analyzed the diets and health outcomes of nearly 429,000 people across nine European countries, including Denmark, France, Germany, Italy, the Netherlands, Norway, Spain, Sweden, and the UK. Participants were followed for approximately 16 years.

A Growing Health Concern Across Europe

Ultra-processed foods include common staples such as sausages, breakfast cereals, crisps, instant noodles, and frozen meals—products often high in sugar, salt, and unhealthy fats.

The study found that the consumption of UPFs varies significantly across Europe, with some countries consuming far more than others:

  • Italy and Romania: UPFs make up 14% of the average diet.
  • United Kingdom and Sweden: UPFs account for 44% of daily food intake.

Esther González-Gil, a WHO scientist and lead author of the study, emphasized the importance of cutting down on processed foods. “Reducing [ultra-processed foods] while adopting a diet rich in unprocessed and minimally processed foods can have a significant positive impact on long-term health,” she told Euronews Health.

Surprising Findings: No Clear Link to Cancer or Alzheimer’s

While previous research has suggested that ultra-processed foods could contribute to cancer and Alzheimer’s disease, this study found no direct link between UPFs and deaths from these conditions.

The discrepancy may be explained by alcohol consumption, the researchers said. Many alcoholic beverages—such as whisky, gin, and rum—are classified as ultra-processed and are often included in similar studies. However, alcohol is a well-known risk factor for cancer on its own, potentially skewing prior findings.

Still, González-Gil noted that further research is needed to explore whether UPFs might contribute to certain types of cancer rather than cancer overall.

Another puzzling outcome was the link between UPFs and Parkinson’s disease, but not Alzheimer’s, despite both being neurodegenerative disorders. The researchers suggested underdiagnosis of Alzheimer’s might be a factor, but the connection remains unclear.

A Call for Dietary Change

The study highlights how even small changes in diet can lead to significant health benefits.

Replacing just 10% of ultra-processed foods in a person’s diet with whole or minimally processed alternatives—such as fruits, vegetables, beans, and whole grains—was linked to a lower risk of death.

Experts say this may be due to a “double effect”—reducing harmful processed foods while increasing nutrient-rich, health-boosting options.

“Prioritizing fresh, whole foods over ultra-processed alternatives is a proactive step towards a healthier life,” González-Gil said.

Regulatory Gaps and the Changing Food Landscape

The researchers acknowledged certain limitations in their study. When the research began in the 1990s, many meals that were homemade at the time may now be heavily processed. Additionally, food safety regulations—such as the EU’s 2021 ban on trans fats—were not factored into the study.

However, the findings add to a growing body of evidence calling for stricter regulations on ultra-processed foods and greater public awareness of their health risks. As consumption of these products continues to rise, experts urge consumers to make more conscious food choices for long-term well-being.

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India Dominates List of Most Polluted Cities as Global Air Quality Crisis Deepens

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A new report has revealed that India is home to six of the world’s nine most polluted cities, highlighting the severity of the country’s air quality crisis. The findings, published by Swiss-based air quality database IQAir, analyzed data from 40,000 monitoring stations across 138 countries, identifying India, Chad, Congo, Bangladesh, and Pakistan as having the dirtiest air globally.

The industrial town of Byrnihat in northeastern India was ranked as the most polluted city worldwide, underlining the impact of rapid industrialization and emissions from factories and vehicles.

A Global Crisis: 83% of Cities Fail Air Quality Standards

The report painted a grim picture of global air pollution, revealing that only 17% of cities worldwide meet air quality guidelines set by the World Health Organization (WHO). Experts warned that actual pollution levels could be even worse, as vast regions, particularly in Africa, lack adequate monitoring infrastructure.

Currently, Africa has only one air quality monitoring station for every 3.7 million people, making it difficult to assess the true extent of pollution. However, progress is being made, with 8,954 new monitoring locations and nearly 1,000 additional sensors deployed in the past year to improve air quality tracking.

Despite these advancements, efforts to monitor pollution suffered a setback last week when the US State Department announced it would stop publicly sharing air quality data from its embassies and consulates worldwide. This move could impact the ability of researchers and policymakers to track pollution levels in some of the world’s most affected regions.

Health Risks of Air Pollution: A Silent Killer

Long-term exposure to polluted air is linked to a range of severe health issues, including respiratory diseases, Alzheimer’s, and cancer, according to Fatimah Ahamad, chief scientist at Malaysia-based Sunway Centre for Planetary Health.

The WHO estimates that air pollution causes around 7 million deaths annually, making it one of the leading environmental health threats.

Ahamad emphasized that urgent action is needed to tackle air pollution, pointing out that nearly 99% of the world’s population lives in areas failing to meet recommended air quality standards.

“If you have bad water, you can tell people to wait for a few hours to get clean water. But if you have bad air, you cannot tell people to stop breathing,” she said.

How Cities Are Fighting Back

While the crisis remains severe, some cities have successfully improved air quality through strict regulations and clean energy initiatives.

  • Beijing, Seoul, and Rybnik (Poland) have implemented stricter controls on vehicle emissions, power plants, and industrial pollution while promoting public transport and renewable energy.
  • In Southeast Asia, the ASEAN agreement on transboundary haze pollution aims to curb pollution from forest fires, though its success has been limited so far.

Air Pollution and Climate Change: A Common Battle

Shweta Narayan, a campaign lead at the Global Climate and Health Alliance, stressed that regions with the worst air pollution are often the same places where large amounts of greenhouse gases are emitted from burning coal, oil, and gas.

“Air pollution and climate change are two sides of the same coin,” Narayan said, adding that reducing fossil fuel use would not only slow global warming but also improve air quality and public health worldwide.

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EU Health Ministers Push for Critical Medicines to Be Included in Defence Funding

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A coalition of 11 EU health ministers is calling for the European Union to integrate funding for critical medicines into its broader defence strategy. The proposal, outlined in an op-ed published on Euronews, urges the inclusion of the upcoming Critical Medicines Act within the EU’s new defence spending framework, citing medicine security as a crucial element of European stability.

The ministers—from Belgium, Czechia, Cyprus, Estonia, Germany, Greece, Latvia, Lithuania, Portugal, Slovenia, and Spain—argue that without a secure supply of essential medicines, Europe’s defence capabilities could be at risk.

A Call for Strategic Investment in Medicine Security

The proposed Critical Medicines Act, set to be unveiled this week by the European Commission, aims to address severe shortages of essential medicines such as antibiotics, insulin, and painkillers. The initiative would focus on medicines that are difficult to source, often relying on a limited number of manufacturers or imports from non-EU countries.

The health ministers advocate for the act to be financed under the EU’s defence budget, allowing it to access part of the €800 billion expected to be mobilized under the Rearm Europe plan. This defence funding package, discussed at last week’s extraordinary EU summit, is designed to ramp up military and security spending across the bloc.

The proposal suggests embedding medicine production investments within a new €150 billion EU defence instrument, which would enable the Commission to borrow from capital markets, issue bonds, and lend to member states.

Parallels with U.S. Defence Strategy

In their op-ed, the ministers drew comparisons to the United States’ Defence Production Act (DPA), which classifies pharmaceutical supply chains as a national security concern. The DPA allows the U.S. government to map supply chains, identify vulnerabilities, and prioritize investments in domestic pharmaceutical production.

The European ministers warn that Europe’s heavy reliance on pharmaceutical imports from Asia—where up to 80% of key medicine ingredients are sourced—poses a serious risk in times of crisis or geopolitical tensions.

“If the supply chain of antibiotics is interrupted in the midst of an escalating conflict, routine surgeries become high-risk procedures, and easily treatable infections could turn fatal,” the ministers wrote. “Foreign actors could exploit this dependency, creating a major security risk for Europe.”

Budget Implications and Political Uncertainty

The push for integrating medicine funding into defence spending comes amid uncertainty over future EU health budgets. The EU4Health programme, launched in response to the COVID-19 pandemic, received €5.3 billion in funding, but recent cuts—including the reallocation of €1 billion to aid Ukraine—have raised concerns over its sustainability.

The European Commission’s next seven-year budget is expected to be tight, and there are indications that dedicated health funding could be merged with other sectors or even eliminated. The proposed defence-linked mechanism, however, could allow increased national health spending by temporarily exempting defence-related expenditures—including medicine security—from EU fiscal limits for four years.

Will the Proposal Gain Political Backing?

It remains uncertain whether the European Commission and Members of the European Parliament (MEPs) will incorporate the ministers’ proposal into legislative talks on the Critical Medicines Act. While some policymakers may welcome a stronger pharmaceutical supply chain as part of Europe’s strategic autonomy, others may be reluctant to blur the lines between health policy and defence spending.

With the legislative proposal expected on Tuesday, the debate over how Europe secures its essential medicines is set to intensify in the coming weeks.

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