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Experts Explore Link Between Maternal Infections and Autism Risk

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The relationship between maternal infections during pregnancy and the increased likelihood of autism in children has been a topic of growing research interest. While autism spectrum disorder (ASD) is not classified as an illness or disease but rather a range of traits with varying severity, scientists continue to examine factors that may influence its development.

Investigating Maternal Infections

One area of focus is the potential role of infections such as influenza during pregnancy. Research suggests that such infections may contribute to a higher risk of autism, though they are not considered direct causes. “Our work suggests that women with febrile episodes, high antibody levels to certain viruses like herpes simplex type 2, or confirmed influenza cases are at greater risk of having children diagnosed with ASD,” explained Dr. Ian Lipkin, director of Columbia University’s Center for Infection and Immunity, in an interview with Euronews Health.

Lipkin’s study emphasized laboratory-confirmed flu cases and found evidence of increased ASD risk when severe flu symptoms were reported. He noted that maternal immune responses, rather than the virus itself, might be the key factor, as inflammation could disrupt normal fetal development.

Understanding the Role of Inflammation

To explore this further, researchers have turned to animal models. Dr. Irene Sanchez Martin, a postdoctoral researcher at Cold Spring Harbor Laboratory, presented findings from her study on how maternal immune activation (MIA) in mice correlates with neurodevelopmental disorders resembling autism in humans.

Her research simulated viral infections during pregnancy, equivalent to the first trimester in humans, and observed early developmental deficits in embryos, particularly in males. “We cannot say that a mouse has autism,” Sanchez Martin clarified, “but they can exhibit behavioral abnormalities associated with neurodevelopmental disorders, including autism.”

The study highlighted disruptions in the fetal environment, such as changes to the amniotic fluid and placenta, as potential contributors to developmental issues.

Focus on Inflammation, Not the Virus

Both Lipkin and Sanchez Martin emphasized the role of inflammation over the specific infectious agent. Elevated levels of cytokines, markers of inflammation, were commonly observed in mothers of children diagnosed with autism. “It’s the inflammation that is associated with these problems, not the infectious agent itself,” Sanchez Martin stated.

While animal studies cannot fully replicate human conditions, they provide insights into how maternal immune responses might influence fetal development. These findings underscore the need for further research into the complex interactions between genetic, environmental, and immunological factors in autism.

Understanding these connections could lead to preventive measures and improved maternal health strategies, offering hope for reducing the impact of such risks on child development.

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UK Cancer Care Disparities Highlighted in New Report

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A recent report from Cancer Research UK reveals stark disparities in cancer care across the United Kingdom, with cancer death rates nearly 60% higher in the most deprived areas compared to wealthier regions. The analysis estimates that about 28,400 cancer deaths each year—roughly three in every 20—are linked to socioeconomic inequality.

The study found that nearly one in 10 cancer diagnoses is associated with neighborhood deprivation, measured by factors such as income, education, and access to services. Lung cancer accounts for almost half of these deprivation-related deaths.

“These figures are shocking and unacceptable,” said Ian Walker, Cancer Research UK’s executive director of policy and information. He pointed to disparities in cancer risks, delayed diagnoses, and limited access to treatment as key drivers of the problem.

Two major risk factors—smoking and obesity—are more prevalent in deprived areas. Smoking rates are three times higher in these communities, and nearly 40% of residents are classified as obese. Limited access to green spaces and healthy food further contributes to these health challenges.

The report also highlighted differences in cancer diagnosis and treatment. People in deprived areas are more likely to be diagnosed at later stages, reducing their chances of survival. For certain cancers, they are less likely to receive chemotherapy, surgery, or innovative treatments. In England, many patients in these areas wait 104 days—over three months—or longer to begin treatment after an urgent referral for suspected cancer.

Walker emphasized the importance of early diagnosis, which can significantly improve survival rates. To address these issues, the charity is urging the UK government to increase funding for cancer and prevention services in high-need areas, including smoking cessation programs and nationwide lung cancer screenings.

“Beating cancer must mean beating it for everybody,” Walker said, underscoring the need to close the care gap and ensure equal access to life-saving treatments across all communities.

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Georgia Woman Sues Fertility Clinic After Embryo Mix-Up Leads to Custody Loss

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A woman from Georgia, United States, is suing a fertility clinic after discovering she had given birth to another couple’s baby due to an embryo mix-up.

Krystena Murray, 38, became pregnant through in vitro fertilization (IVF) in 2023 and delivered a healthy baby boy in December. However, she immediately suspected something was wrong when she noticed the child was Black, while both she and her sperm donor are White. Subsequent DNA tests confirmed that the baby was not biologically related to her.

Murray claims that doctors at Coastal Fertility Specialists mistakenly implanted another couple’s embryo during the IVF procedure. Despite the mix-up, she initially decided to raise the child as her own. However, after notifying the clinic of the error, the staff informed the baby’s biological parents, who then sought custody through legal action.

Facing a court battle she felt she could not win, Murray relinquished custody when the child was five months old in May 2024. “I have never felt so violated, and the situation has left me emotionally and physically broken,” she said during a virtual press conference. “I spent my entire life wanting to be a mom. I loved, nurtured, and grew my child, and I would have done literally anything to keep him.”

Lawsuit and Clinic’s Response

On Tuesday, Murray filed a civil lawsuit against the fertility clinic, alleging negligence and seeking unspecified monetary damages for the emotional distress caused by the mix-up. Her attorney, Adam Wolf, emphasized the gravity of the mistake, stating that Murray had been “turned into an unwitting surrogate, against her will, for another couple.”

In a statement, Coastal Fertility Specialists acknowledged the error, describing it as “unprecedented” and apologizing to those affected. The clinic assured that it had implemented new safeguards to prevent similar incidents, adding, “This was an isolated event with no further patients affected. We are doing everything we can to make things right.”

Unanswered Questions and Rare Occurrence

Murray’s attorney noted that she still does not know what happened to her own embryos. While mistakes involving lost or damaged embryos are not uncommon, instances of transferring the wrong embryo are considered rare.

“Fertility clinics engage in vitally important work,” Wolf said. “With that amazing work comes a real responsibility. And when fertility clinics make mistakes like this, the consequences are life-altering.”

Reflecting on her experience, Murray expressed hope that her case would raise awareness among women considering IVF. “I considered the risks of bleeding, infection, and even death,” she said. “But never once did I think I might give birth to someone else’s child and then have them taken away from me.”

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Tuscany Becomes First Italian Region to Approve Assisted Suicide Law

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Tuscany has become the first region in Italy to approve legislation regulating medically assisted suicide, marking a historic step in the country’s ongoing debate over end-of-life rights. However, the decision could face legal challenges from Italy’s far-right-led government, which remains largely opposed to euthanasia.

The right-to-die bill was passed by a vote of 27-13 in the region’s governing council, which is controlled by the centre-left. The new law establishes a formal process for patients seeking medically assisted suicide and ensures access to the procedure through the regional health system.

New Regulations for Assisted Suicide

Under the law, a medical and ethics commission will have 30 days to review an end-of-life request. If approved, the regional health services must provide the necessary medication and a doctor within 10 days.

The legislation also includes a conscientious objection clause, allowing medical professionals to opt out of participating in the procedure.

Regional Governor Eugenio Giani, a supporter of the bill, defended the move as a necessary step to clarify the legal framework surrounding assisted suicide in Italy.

“The law does nothing more than provide objective procedures and clarity,” Giani said before the vote. “I feel that we are giving a national message.”

Legal Uncertainty and Potential Challenges

Italy’s Constitutional Court ruled in 2019 that assisted suicide is legal for patients who suffer from an irreversible illness causing intolerable physical and psychological pain, provided they are capable of making a free and conscious decision.

However, the Italian Parliament has not passed national legislation to regulate the practice, leaving a legal gray area that Tuscany’s new law attempts to address.

The bill may face constitutional challenges from Prime Minister Giorgia Meloni’s government, which has taken a strong stance against euthanasia and assisted suicide. If the national government argues that Tuscany has overstepped its powers, the law could be blocked or overturned in court.

Italy Joins a Growing European Debate

While only a handful of European countries currently allow assisted suicide, the issue is gaining traction across the continent. Countries such as Switzerland, Belgium, and the Netherlands have long-established laws permitting euthanasia under strict conditions.

Elsewhere, including the United Kingdom, debates over assisted dying laws continue, reflecting shifting attitudes toward end-of-life choices.

For now, Tuscany’s law stands as a landmark decision, potentially paving the way for broader national discussions on the right to die in Italy.

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